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  4. Recombinant Human Speedy protein C (SPDYC)

Recombinant Human Speedy protein C (SPDYC)

  • 货号：
    CSB-YP702803HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP702803HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP702803HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP702803HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP702803HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SPDYC
  • Uniprot No.：
  • 别名：
    SPDYC; Speedy protein C; Rapid inducer of G2/M progression in oocytes C; RINGO C; hSpy/Ringo C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-293
  • 氨基酸序列
    MLWAIPELGS PCPISISYEM SDSQDPTTSP VVTTQVELGG CSRQGGGNGF LRFRQHQEVQ AFLSLLEDSF VQEFLSKDPC FQISDKYLLA MVLVYFQRAH LKLSEYTHSS LFLALYLAND MEEDLEGPKC EIFPWALGKD WCLRVGKFLH QRDKLWARMG FRAVVSRQCC EEVMAKEPFH WAWTRDRRPH HGGVQRVCPQ VPVRLPRGPG LSPPHCSPCG LPQHCSSHLL KPVSSKCPSL TSECHRPPSQ NYLSRVKNAW GGDFLIVLPP QMQLEPGTYS LRIFPKPPAR PGH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.
  • 基因功能参考文献：
    1. Results indicate a role for RINGO C in the mitotic checkpoint, which might be mediated by defective recruitment of SAC components and deregulation of the activity of Aurora kinase B. PMID: 20605920
    2. CDK-Speedy/Ringo C complexes positively regulate cell cycle progression during the late S and G(2) phases of the cell cycle. PMID: 18802405
  • 亚细胞定位：
    Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
  • 蛋白家族：
    Speedy/Ringo family
  • 组织特异性：
    Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
  • 数据库链接：

    HGNC: 32681

    OMIM: 614030

    KEGG: hsa:387778

    STRING: 9606.ENSP00000366390

    UniGene: Hs.450642