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  4. Recombinant Human Sodium-dependent noradrenaline transporter (SLC6A2), partial

Recombinant Human Sodium-dependent noradrenaline transporter (SLC6A2), partial

  • 货号：
    CSB-YP021698HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021698HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021698HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021698HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021698HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC6A2
  • Uniprot No.：
  • 别名：
    NAT1; NET; NET1; Neurotransmitter transporter; Norepinephrine transporter; SC6A2_HUMAN; Slc6a2; SLC6A5; Sodium dependent noradrenaline transporter; Sodium-dependent noradrenaline transporter; Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5; Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Solute carrier family 6 member 2; Solute carrier family 6 member 5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
  • 基因功能参考文献：
    1. Our case-control study and meta-analysis suggest that the NET gene G1287A polymorphism may not be involved in the etiology of schizophrenia in the Chinese Han population PMID: 29431473
    2. genetic association/pharmacogenetic studies in population in Switzerland: Data from controlled studies suggest that SNPs in SLC6A2 (rs1861647, rs2242446, rs36029) weakly moderate acute cardiovascular response to MDMA (methylenedioxymethamphetamine, "ecstasy") and may play minor role in adverse cardiovascular events when MDMA is used recreationally. PMID: 29198060
    3. Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension. PMID: 28737436
    4. case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 and DRD2 in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls PMID: 28454051
    5. nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed. PMID: 28176268
    6. T allele of the SNP rs7194256 in the 3'UTR of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations PMID: 27046647
    7. Polymorphisms of COMT (c.649G>A), MAO-A (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease PMID: 28418735
    8. NET rs2242446/T-182C may serve as a biomarker to predict the likelihood of remission with venlafaxine in older adults with major depression. These findings may help to optimize antidepressant outcomes in older adults. PMID: 28068779
    9. These results suggest that NET polymorphism may affect the SNRI response in Korean panic disorder patients. PMID: 26508020
    10. Imaging genetic study showed significant differences in NET nondisplaceable binding potential in patients with attention deficit hyperactivity disorder compared to healthy controls, depending on their genotype PMID: 26678348
    11. NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes. PMID: 26786096
    12. In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene. PMID: 26960194
    13. This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety PMID: 26212818
    14. Study identified the haplotype rs36011 (T)/rs1566652 (G) as a novel genetic marker involved in both attention-deficit/hyperactivity disorder disease susceptibility and visual memory PMID: 25554436
    15. a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients PMID: 25650523
    16. NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population. PMID: 26051731
    17. Different combinations of T-182C and the G1287A polymorphisms of NET gene might increase morbidity risk of major depression subpopulations PMID: 26061302
    18. A Cox regression analysis for remission incidence during the 8-week treatment course significantly depends on SLC6A2 variants (rs28386840, rs40434, and rs187714)from major depression after venlafaxine treatment. PMID: 25512257
    19. The response to venlafaxine was assessed after 4 weeks of treatment and correlated to serum concentration and functional variants in genes encoding SLC6A2 and SLC6A4 PMID: 25295552
    20. The rs2242446 genotype, coded additively as the number of minor (G) alleles, significantly predicted both scale scores and count of anxious arousal symptoms but none of the other symptom clusters or severity or probable diagnosis of PTSD. PMID: 25919853
    21. polymorphisms of 1287G/A, -182T/C and -3081A/T in the norepinephrine transporter gene are not risk factors in alcohol dependence. PMID: 25831948
    22. The results of this study do not support the association between the SLC6A2 and the diagnosis or phenotype of autism spectrum disorder. PMID: 24381062
    23. results do not indicate involvement of changes in brain Norepinephrine Transporter availability or distribution in the pathogenesis of Attention deficit/hyperactivity disorder. PMID: 25338091
    24. Our results suggest that SLC6A2 polymorphisms were associated with suicide risk in patients with major depressive disorder. PMID: 24655776
    25. Data indicate that [(18)F]-MFBG PET imaging shows higher sensitivity, better detection of small lesions with low NET protein expression. PMID: 24573553
    26. The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder. PMID: 24565995
    27. meta-analysis did not suggest a confirmed association between the T-182C polymorphism of the NET gene and major depressive disorder. PMID: 24374057
    28. Duloxetine significantly affected norpepinephrine turnover in the central nervous system and periphery; these effects presumably occurred via inhibition of reuptake by NET, as indicated by effects on functional reuptake inhibition ex vivo. PMID: 24346757
    29. Report NET occupancy in human thalamus after oral administration of quetiapine XR. PMID: 23809226
    30. The results do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population. PMID: 23969988
    31. The results of this study suggest that DNA variants of both SLC6A2 and ADRA2A in the adrenergic neurotransmitter system might alter the response to atomoxetine. PMID: 23266789
    32. NK1R forms physical complexes with NET. PMID: 23979140
    33. Our findings suggest that the norepinephrine transporter T-182C and G1287A polymorphisms are not susceptibility factors for major depressive disorder. PMID: 23648227
    34. Haplotype analysis demonstrates a significant association between attention deficit hyperactivity disorder (ADHD) and SLC6A2 gene. PMID: 23052569
    35. a comprehensive phenotype/genotype analyses of the norepinephrine transporter gene (SLC6A2) in ADHD shows a relationship to maternal smoking during pregnancy PMID: 23185385
    36. Our results provide evidence for the possible role of the G1287A and A-3081T genotypes of SLC6A2 in methylphenidate-induced improvement in attentional performance and support the noradrenergic hypothesis for the pathophysiology of ADHD. PMID: 22591463
    37. Analysis of drug sensitivity profiles provides novel information on drug binding modes in hSERT and hNET and identifies specific S1 residues as important molecular determinants for inhibitor potency and hSERT/hNET selectivity. PMID: 23086945
    38. SLC6A2 promoter-3-GA/GG genotype may be a susceptibility gene for patients of essential hypertension with severe blood-stasis pattern. PMID: 20681272
    39. chromatin-modifying events associated with SLC6A2 gene suppression may constitute a mechanism of postural tachycardia syndrome PMID: 22723437
    40. This study demonistrated that the noradrenaline (SLC6A2) transporter polymorphisms may have an effect on response to kava. PMID: 22311378
    41. Our results indicate that both neural endophenotypes and genetic variation in SLC6A2 give rise to the various manifestations of impulsive behavior PMID: 22544311
    42. In our Caucasian study cohort the presence of the minor rs168924 single-nucleotide polymorphism in the SLC6A2 was associated with lower prevalence of hypertension. PMID: 22533655
    43. Although the results of this study should be interpreted cautiously, they suggest that polymorphisms of the NET gene may contribute to an intermediate phenotype of attention deficit/hyperactivity disorder. PMID: 22405810
    44. family-based study suggest that haplotype blocks within different regions of SLC6A2 show differential association with ADHD based on sex and subtype PMID: 22297068
    45. SLC6A2 is involved in clearing extracellular norepinephrine from the synaptic cleft. PMID: 21070505
    46. The norepinephrine transporter could be a susceptibility gene for Parkinson disease. PMID: 21416264
    47. Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells PMID: 22234472
    48. the present study showed no association of a functional variant, capable to downregulate the expression of SLC6A2, in a German family-based ADHD sample. PMID: 21739117
    49. Data show that ten of the 18 high-scoring drugs tested experimentally were found to be NET inhibitors. PMID: 21885739
    50. Dexamethasone-induced increase in NET expression is mediated by the glucocorticoid receptor via a transcriptional mechanism involving interaction of C/EBP-beta with a C/EBP-beta response element. PMID: 21883217

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  • 相关疾病：
    Orthostatic intolerance (OI)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A2 subfamily
  • 数据库链接：

    HGNC: 11048

    OMIM: 163970

    KEGG: hsa:6530

    STRING: 9606.ENSP00000219833

    UniGene: Hs.78036