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  4. Recombinant Human Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1)

Recombinant Human Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1)

  • 中文名称：
    人STYXL1重组蛋白
  • 货号：
    CSB-YP897590HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人STYXL1重组蛋白
  • 货号：
    CSB-EP897590HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人STYXL1重组蛋白
  • 货号：
    CSB-EP897590HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人STYXL1重组蛋白
  • 货号：
    CSB-BP897590HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人STYXL1重组蛋白
  • 货号：
    CSB-MP897590HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STYXL1
  • Uniprot No.：
  • 别名：
    Dual specificity phosphatase inhibitor MK STYX; Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; DUSP24; Map kinase phosphatase like protein MK STYX; Map kinase phosphatase-like protein MK-STYX; MKSTYX; Serine/threonine/tyrosine interacting like protein 1; Serine/threonine/tyrosine-interacting-like protein 1; STYL1_HUMAN; STYXL1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-313
  • 氨基酸序列
    MPGLLLCEPT ELYNILNQAT KLSRLTDPNY LCLLDVRSKW EYDESHVITA LRVKKKNNEY LLPESVDLEC VKYCVVYDNN SSTLEILLKD DDDDSDSDGD GKDLVPQAAI EYGRILTRLT HHPVYILKGG YERFSGTYHF LRTQKIIWMP QELDAFQPYP IEIVPGKVFV GNFSQACDPK IQKDLKIKAH VNVSMDTGPF FAGDADKLLH IRIEDSPEAQ ILPFLRHMCH FIEIHHHLGS VILIFSTQGI SRSCAAIIAY LMHSNEQTLQ RSWAYVKKCK NNMCPNRGLV SQLLEWEKTI LGDSITNIMD PLY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytically inactive phosphatase. By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules. Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149'. Inhibits PTPMT1 phosphatase activity. By inhibiting PTPMT1, positively regulates intrinsic apoptosis. May play a role in the formation of neurites during neuronal development.
  • 基因功能参考文献：
    1. this study revealed STYXL1 as a novel candidate gene for moderate intellectual disability, seizures and behavioral complexities. PMID: 25724587
    2. our data support a model in which MK-STYX controls apoptosis by negatively regulating PTPMT1. PMID: 24709986
    3. The pseudophosphatase MK-STYX plays a key role in the cellular response to stress. PMID: 23163895
    4. MK-STYX regulates mitochondrial outer membrane permeabilization using a distinct mechanism. PMID: 21262771
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 18165

    KEGG: hsa:51657

    STRING: 9606.ENSP00000248600

    UniGene: Hs.11615