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  4. Recombinant Human Secretoglobin family 3A member 2 (SCGB3A2)

Recombinant Human Secretoglobin family 3A member 2 (SCGB3A2)

  • 中文名称：
    人SCGB3A2重组蛋白
  • 货号：
    CSB-YP839392HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SCGB3A2重组蛋白
  • 货号：
    CSB-EP839392HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SCGB3A2重组蛋白
  • 货号：
    CSB-EP839392HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SCGB3A2重组蛋白
  • 货号：
    CSB-BP839392HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SCGB3A2重组蛋白
  • 货号：
    CSB-MP839392HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SCGB3A2
  • Uniprot No.：
  • 别名：
    LU103; Pneumo secretory protein 1; PnSP-1; PNSP1; SCGB3A2; Secretoglobin family 3A member 2; SG3A2_HUMAN; UGRP1; Uteroglobin-related protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-93
  • 氨基酸序列
    FLINKVPLP VDKLAPLPLD NILPFMDPLK LLLKTLGISV EHLVEGLRKC VNELGPEASE AVKKLLEALS HLV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
  • 基因功能参考文献：
    1. rs151333009 SNP showed a monomorphic genotype. Two promoter SNPs (rs6882292, -659 G/A and rs1368408, -112 G/A) showed significant association with asthma. These results suggest that the promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. PMID: 28422086
    2. This meta-analysis suggests that SCGB3A2 polymorphism at positions -112G>A was associated with Graves' disease both in Chinese and Caucasian population. PMID: 23934357
    3. the SCGB3A2 -112G >A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and Graves' disease PMID: 21170691
    4. Reduced production of UGRP1, which is likely due, at least in part, to a local cytokine environment, may contribute to the hyper-inflammation in chronic rhinosinusitis and correlates with response to surgery. PMID: 21385388
    5. This study documents the association between polymorphisms in UGRP1 and the common cold, suggesting a potential role in its pathogenesis. PMID: 21410962
    6. Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
    7. pattern of UGRP-1 concentration resembled that of Clara cell protein, both proteins occurring in high concentrations in amniotic fluid, sputum and BALF and in much lower concentrations in serum and urine PMID: 20843168
    8. association was detected between SCGB3A2 and U.K. Caucasian Graves' disease subjects but the size of effect was smaller than that seen in the Oriental population (odds ratio = 1.28-1.73). PMID: 20210668
    9. polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma PMID: 11813133
    10. By in situ hybridization, UGRP1 is found to be expressed by lung Clara-like cells in the bronchial epithelium and up-regulated in lung epithelium of a patient with cystic fibrosis. PMID: 12847263
    11. results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
    12. plasma UGRP1 levels were associated with the G-112A UGRP1 gene promoter polymorphism and the severity of asthma PMID: 18089940
    13. results suggest that the -112G/A polymorphism does not play a significant role in the genetic predisposition of the UGRP1 gene in atopic asthma in the Sicilian population PMID: 18201431
    14. SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, UGRP subfamily
  • 组织特异性：
    Highly expressed in lung and trachea. Detected throughout the airway epithelium in lung, with slightly higher expression in large airways. Found in lung submucosal gland acinus where it localizes to serous-like cells. Probably expressed in club/Clara cell
  • 数据库链接：

    HGNC: 18391

    OMIM: 606531

    KEGG: hsa:117156

    STRING: 9606.ENSP00000296694

    UniGene: Hs.483765