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  4. Recombinant Human Retrotransposon-derived protein PEG10 (PEG10)

Recombinant Human Retrotransposon-derived protein PEG10 (PEG10)

  • 货号：
    CSB-YP768203HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP768203HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP768203HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP768203HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP768203HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PEG10
  • Uniprot No.：
  • 别名：
    AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB 1; HB1; KIAA1051; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3-like protein 1; MEF3L; MEF3L1; MyEF 3; Myelin expression factor 3-like protein 1; Paternally expressed 10; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; Peg10; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Retrotransposon-derived protein PEG10; RGAG3; Ty3/Gypsy-like protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-708
  • 氨基酸序列
    MTERRRDELS EEINNLREKV MKQSEENNNL QSQVQKLTEE NTTLREQVEP TPEDEDDDIE LRGAAAAAAP PPPIEEECPE DLPEKFDGNP DMLAPFMAQC QIFMEKSTRD FSVDRVRVCF VTSMMTGRAA RWASAKLERS HYLMHNYPAF MMEMKHVFED PQRREVAKRK IRRLRQGMGS VIDYSNAFQM IAQDLDWNEP ALIDQYHEGL SDHIQEELSH LEVAKSLSAL IGQCIHIERR LARAAAARKP RSPPRALVLP HIASHHQVDP TEPVGGARMR LTQEEKERRR KLNLCLYCGT GGHYADNCPA KASKSSPAGK LPGPAVEGPS ATGPEIIRSP QDDASSPHLQ VMLQIHLPGR HTLFVRAMID SGASGNFIDH EYVAQNGIPL RIKDWPILVE AIDGRPIASG PVVHETHDLI VDLGDHREVL SFDVTQSPFF PVVLGVRWLS THDPNITWST RSIVFDSEYC RYHCRMYSPI PPSLPPPAPQ PPLYYPVDGY RVYQPVRYYY VQNVYTPVDE HVYPDHRLVD PHIEMIPGAH SIPSGHVYSL SEPEMAALRD FVARNVKDGL ITPTIAPNGA QVLQVKRGWK LQVSYDCRAP NNFTIQNQYP RLSIPNLEDQ AHLATYTEFV PQIPGYQTYP TYAAYPTYPV GFAWYPVGRD GQGRSLYVPV MITWNPHWYR QPPVPQYPPP QPPPPPPPPP PPPSYSTL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
  • 基因功能参考文献：
    1. PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors. PMID: 29727698
    2. Results demonstrated that an increased expression of PEG10 is associated vessel invasion, and the overall survival time of PC patients. E2F-1 mediated PEG10 overexpression promotes pancreatic cancer (PC) cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK/MMP7 pathway. These results suggest that PEG10 may serve as an oncogene in PC pathogenesis. PMID: 28193232
    3. miR-122 suppresses PEG10 expression via direct binding to the 3'-UTR of the PEG10 transcript. PMID: 27370270
    4. PEG10 expression associates with the lymph node metastasis and overall survival of hepatocellular carcinoma patients.PEG10 expression level is essential for TGF-beta1 induced epithelialmesenchymal transition. PMID: 28004118
    5. Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro. PMID: 25864113
    6. PEG10 protein could be a potential biomarker predicting early recurrence and recurrence-free survival in HCC patients after curative resection, even in those with normal serum alpha-fetoprotein levels. PMID: 25687862
    7. Study shows that expression level of PEG10 was significantly elevated in breast cancer tissues and associated with distant metastasis and poor clinical outcome and provides evidence that PEG10 is a crucial oncogene. PMID: 26934961
    8. important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1 PMID: 26680220
    9. Results revealed that PEG10 high expression was closely associated with the TNM classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells. PMID: 25199998
    10. The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia. PMID: 25526181
    11. elevated expression of PEG10 is likely to be involved in the pathophysiology of preeclampsia PMID: 22137777
    12. promotes migration of Burkitt's lymphoma cells via upregulation of matrix metalloproteinase-2 and -9 PMID: 22673314
    13. Overexpression of PEG10 and TSG101 was detected in gallbladder adenocarcinoma. PMID: 21455631
    14. PEG10 imprinting is lost in a majority of hepatocellular carcinomas and no correlation exists between the imprinting status of PEG10 and its expression in HCC tissues. PMID: 21205473
    15. the mRNA expression level of PEG10 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. PMID: 21767414
    16. In third trimester PEG10 was downregulated in fetal samples group PMID: 20484977
    17. PEG10 gene is imprinted, with preferential expression from the paternal allele. PMID: 11318613
    18. miR-122 may be involved in regulation of PEG10 expression hepatoma cell lines. PMID: 20460050
    19. study provides new data on the genomic organization as well as expression and translation of PEG10, a prerequisite in order to study and understand the role of PEG10 in cancer, embryonic development and normal cell homeostasis PMID: 20084274
    20. Evidence for translation initiation from an in-frame, upstream non-AUG (CUG) codon, and from the downstream AUG, resulting in different isoforms. PMID: 20084274
    21. PEG10 is a probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of hepatocellular carcinomas. PMID: 20362226
    22. placental PEG10 is downregulated at early hypoxic phase, and highly activated at 11-12 wk of gestation PMID: 12620933
    23. Exogenous expression of PEG10 conferred oncogenic activity. PEG10 protein associated with SIAH1, a mediator of apoptosis, and overexpression of PEG10 decreased the cell death mediated by SIAH1. PMID: 12810624
    24. Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the human hepatocyte. PMID: 14576465
    25. Data show that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulated PEG10 expression and function in leukemic B cells. PMID: 16225771
    26. PEG10 is a direct target of c-MYC; findings link cancer genetics and epigenetics by showing that a classic proto-oncogene, MYC, acts directly upstream of a proliferation-positive imprinted gene, PEG10 PMID: 16423995
    27. PEG10 represents a novel marker in B-cell chronic lymphocytic leukemia PMID: 17621626
    28. the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals PMID: 17942406
    29. The results showed that maintaining sufficient levels of PEG10 may be important during early pregnancy. Lower levels of PEG10 might be one of reasons that underlie inevitable abortion. PMID: 18550496
    30. The expression profile of hepatocelluar carcinoma tissues suggested E2Fs were involved in PEG10 regulation. PMID: 18625225
    31. PEG10 contains two overlapping reading frames from which two proteins are translated by a -1 ribosomal frameshift mechanism. PMID: 15611116
    32. Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes. PMID: 15767280

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ACVRL1.
  • 组织特异性：
    Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level).
  • 数据库链接：

    HGNC: 14005

    OMIM: 609810

    KEGG: hsa:23089

    STRING: 9606.ENSP00000417587

    UniGene: Hs.147492