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  4. Recombinant Human Receptor-type tyrosine-protein phosphatase gamma (PTPRG), partial

Recombinant Human Receptor-type tyrosine-protein phosphatase gamma (PTPRG), partial

  • 货号：
    CSB-YP019054HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019054HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019054HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019054HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019054HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PTPRG
  • Uniprot No.：
  • 别名：
    H RG317H01.1; HPTPG; Protein tyrosine phosphatase gamma; Protein tyrosine phosphatase receptor type G; Protein tyrosine phosphatase receptor type gamma polypeptide; Protein-tyrosine phosphatase gamma; PTPG; PTPgamma; Ptprg; PTPRG protein; PTPRG_HUMAN; R PTP gamma; R-PTP-gamma; Receptor type protein phosphatase gamma; Receptor type tyrosine protein phosphatase gamma; Receptor tyrosine phosphatase gamma; Receptor-type tyrosine-protein phosphatase gamma; RPTPG
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possesses tyrosine phosphatase activity.
  • 基因功能参考文献：
    1. miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer PMID: 27602768
    2. Co-localization experiments performed with both anti-PTPRG antibodies identified the presence of isoforms and confirmed protein downregulation at diagnosis in the Philadelphia-positive myeloid lineage (including CD34+/CD38bright/dim cells). PMID: 28637510
    3. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3. In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7). PMID: 26830138
    4. Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage. PMID: 25775014
    5. Our results showed that there was no significant association between any of five reported SNPs of TCF4 and PTPRG genes and the occurrence of Fuchs' endothelial dystrophy; only rs7640737 in PTPRG showed an increased risk for corneal dystrophy. PMID: 23758498
    6. SNPs in PTPRG were not associated with FCD in Caucasians. PMID: 25299301
    7. PTPRG is a JAK2 phosphatase that negatively regulates leukocyte integrin beta2 activation. PMID: 25624455
    8. Mutations in PDGFRB cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor. PMID: 25158255
    9. Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma. PMID: 25196286
    10. PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be critical for mutant RAS-induced cell growth. PMID: 24496747
    11. found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality PMID: 21795790
    12. Tumor-specific methylation of the first intron of the receptor protein-tyrosine phosphatase gamma gene was found in both sporadic and Lynch syndrome colorectal cancers. PMID: 21150880
    13. Downregulation of Protein tyrosine phosphatase receptor type {gamma} is associated with chronic myeloid leukemia. PMID: 20959494
    14. PTPRG inhibited breast tumor formation in vivo; PTPRG may up-regulate p21(cip) and p27(kip) proteins through the ERK1/2 pathway. PMID: 20651337
    15. findings implicate PTPRG, PTPRZ and CNTNs as a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks PMID: 20133774
    16. There were significant differences of PTPRG gene methylation and PTPRG mRNA expression between gastric primary cancer and lymph node metastases. PMID: 18646686
    17. both estradiol-17beta and zeranol regulate PTPgamma expression in human breast; epithelial-stromal cell interaction is important in regulation of PTPgamma expression by estrogenically active agents PMID: 11859871
    18. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. PMID: 12553013
    19. PTPgamma may function as an important modulator in regulating the process of tumorigenesis in human breast. PMID: 14676845
    20. Promoter hypermethylation of PTPRG is associated with cutaneous T-cell lymphoma PMID: 15897551
    21. Significant difference exists in methylation of gene PTPRG between primary tumor and metastatic lymph nodes of gastric cancer. PMID: 17963294
    22. PTPRG may contribute to tumorigenesis. PMID: 18829573

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 5 subfamily
  • 组织特异性：
    Found in a variety of tissues.
  • 数据库链接：

    HGNC: 9671

    OMIM: 176886

    KEGG: hsa:5793

    STRING: 9606.ENSP00000418112

    UniGene: Hs.595541