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  4. Recombinant Human RAD50-interacting protein 1 (RINT1)

Recombinant Human RAD50-interacting protein 1 (RINT1)

  • 货号：
    CSB-YP747351HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP747351HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP747351HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP747351HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP747351HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RINT1
  • Uniprot No.：
  • 别名：
    DKFZp667H2324 ; FLJ11785 ; HsRINT 1; HsRINT-1; HsRINT1; RAD50 interacting protein 1 ; RAD50 interactor 1; RAD50-interacting protein 1; RINT 1 ; RINT-1; RINT1; RINT1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-792
  • 氨基酸序列
    MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
  • 基因功能参考文献：
    1. Study presents evidence that in the Caucasian population, RINT1 does not represent a moderate- penetrance breast cancer susceptibility gene, and find no evidence to support an association of RINT1 mutation with Lynch syndrome-related cancer incidence in breast cancer families. PMID: 27544226
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
    3. HPV E2 protein targets Rad50-interacting protein 1 (Rint1) to facilitate virus genome replication. PMID: 28031358
    4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
    5. Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures. PMID: 25304616
    6. Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome. PMID: 25050558
    7. RINT-1 is also required for endosome-to-trans-Golgi network trafficking. PMID: 23885118
    8. RINT1 was validated as a novel glioblastoma oncogene PMID: 23074196
    9. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
    10. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    RINT1 family
  • 数据库链接：

    HGNC: 21876

    OMIM: 610089

    KEGG: hsa:60561

    STRING: 9606.ENSP00000257700

    UniGene: Hs.531388