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  4. Recombinant Human Pyroglutamyl-peptidase 1 (PGPEP1)

Recombinant Human Pyroglutamyl-peptidase 1 (PGPEP1)

  • 中文名称：
    人PGPEP1重组蛋白
  • 货号：
    CSB-YP868349HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PGPEP1重组蛋白
  • 货号：
    CSB-EP868349HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PGPEP1重组蛋白
  • 货号：
    CSB-EP868349HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PGPEP1重组蛋白
  • 货号：
    CSB-BP868349HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PGPEP1重组蛋白
  • 货号：
    CSB-MP868349HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PGPEP1
  • Uniprot No.：
  • 别名：
    2810003H13Rik; 5 oxoprolyl peptidase; 5-oxoprolyl-peptidase; FLJ20208; MGC10812; PAP I; PAP-I; PAPI; Pcp; PGI; pGlu peptidase I; PGP; PGP I; PGP-I; Pgpep1; PGPI; PGPI_HUMAN; Pyroglutamyl aminopeptidase I; Pyroglutamyl peptidase 1; pyroglutamyl peptidase I; Pyroglutamyl-peptidase 1; Pyroglutamyl-peptidase I; pyrrolidone carboxylate peptidase; Pyrrolidone-carboxylate peptidase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-209
  • 氨基酸序列
    MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE YQTVQRLIPA LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR FCPGSQCCVE DGPESIDSII DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD FTYYTSLYQS HGRSAFVHVP PLGKPYNADQ LGRALRAIIE EMLDLLEQSE GKINYCHKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • 基因功能参考文献：
    1. cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis PMID: 26078706
    2. The specific reduction of the levels of pyroglutamyl-aminopeptidase activity in serum of liver cirrhosis patients might be considered as a potential candidate to be included in a combination of markers for the diagnosis of this disease. PMID: 25687677
    3. cloning and sequencing of the human (AJ278828) pyroglutamyl-peptidase I PMID: 12651114
    4. VX-710 modulates Pgp, MRP-1, and BCRP(R482), and has potential as a clinical broad-spectrum multidrug resistance modulator in malignancies. PMID: 15014037
    5. The activities of pyroglutamyl peptidase I and prolyl endopeptidase in necrozoospermia were found to be higher in the corresponding soluble and particulate sperm fractions, respectively, with respect to those measured in normozoospermic semen PMID: 15380924

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C15 family
  • 数据库链接：

    HGNC: 13568

    OMIM: 610694

    KEGG: hsa:54858

    STRING: 9606.ENSP00000269919

    UniGene: Hs.131776