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  4. Recombinant Human Pyrin domain-containing protein 2 (PYDC2)

Recombinant Human Pyrin domain-containing protein 2 (PYDC2)

  • 货号：
    CSB-YP690932HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP690932HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP690932HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP690932HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP690932HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    PYDC2; POP2; Pyrin domain-containing protein 2; Pyrin-only protein 2; cellular POP2; cPOP2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-97
  • 氨基酸序列
    MASSAELDFN LQALLEQLSQ DELSKFKSLI RTISLGKELQ TVPQTEVDKA NGKQLVEIFT SHSCSYWAGM AAIQVFEKMN QTHLSGRADE HCVMPPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA.
  • 基因功能参考文献：
    1. POP2 inhibits inflammasome priming and activation PMID: 28580931
    2. PYDC2 inhibits NF-kB activation through the non-canonical kinase IKK epsilon. PYDC2 interferes with ASC oligomerization and with ASC-inflammasome activation resulting in reduced production of Interleukin-1-beta and reduced IL-18 secretion, as well as reduced pyroptosis. PMID: 28580931
    3. POP2 inhibits both the interaction of ASC with various NLR pyrin domains and inhibits NF-kappaB p65 (RelA). PMID: 17339483
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Predominantly expressed in peripheral blood. Weakly expressed in testis.
  • 数据库链接：

    HGNC: 33512

    OMIM: 615701

    KEGG: hsa:152138

    STRING: 9606.ENSP00000428325

    UniGene: Hs.690618