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  4. Recombinant Human Pyrin domain-containing protein 1 (PYDC1)

Recombinant Human Pyrin domain-containing protein 1 (PYDC1)

  • 中文名称：
    人PYDC1重组蛋白
  • 货号：
    CSB-YP848836HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PYDC1重组蛋白
  • 货号：
    CSB-EP848836HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PYDC1重组蛋白
  • 货号：
    CSB-EP848836HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PYDC1重组蛋白
  • 货号：
    CSB-BP848836HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PYDC1重组蛋白
  • 货号：
    CSB-MP848836HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    PAAD domain only protein; PAAD-only protein 1; POP1; PYC1; PYD (pyrin domain) containing 1; PYDC1; PYDC1_HUMAN; Pyrin domain containing 1; Pyrin domain-containing protein 1; Pyrin only protein 1; Pyrin-only protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-89
  • 氨基酸序列
    MGTKREAILK VLENLTPEEL KKFKMKLGTV PLREGFERIP RGALGQLDIV DLTDKLVASY YEDYAAELVV AVLRDMRMLE EAARLQRAA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
  • 基因功能参考文献：
    1. PYDC1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. Changes in the tertiary structure of mutated pyrin B30.2 domain interrupting the formation of the pyrin-caspase-1 complex are related to the manifestations of Mediterranean familial fever. PMID: 26510601
    3. X-ray diffraction data were collected to a resolution of 3.6 A from a crystal belonging to the cubic space group P23 with unit-cell parameters a=b=c=94.12 A, alpha=beta=gamma=90.00 degrees . PMID: 23519807
    4. NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation. PMID: 12153040
    5. analysis of the 3D structure of human ASC2 protein involved in apoptosis and inflammation PMID: 16403450
    6. ASC2 is a pyrin domain-only protein that regulates inflammatory signaling PMID: 16905547
    7. POP1/ASC2 associates with ASC via PAAD-PAAD interactions and modulates NF-kappa B and pro-caspase-1 regulation by this adapter protein PMID: 12656673

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Predominantly expressed in monocytes, macrophages and granulocytes.
  • 数据库链接：

    HGNC: 30261

    OMIM: 615700

    KEGG: hsa:260434

    STRING: 9606.ENSP00000304336

    UniGene: Hs.58314