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  4. Recombinant Human Protocadherin-11 X-linked (PCDH11X), partial

Recombinant Human Protocadherin-11 X-linked (PCDH11X), partial

  • 中文名称：
    人PCDH11X重组蛋白
  • 货号：
    CSB-YP866326HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PCDH11X重组蛋白
  • 货号：
    CSB-EP866326HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PCDH11X重组蛋白
  • 货号：
    CSB-EP866326HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PCDH11X重组蛋白
  • 货号：
    CSB-BP866326HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PCDH11X重组蛋白
  • 货号：
    CSB-MP866326HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PCDH11X
  • Uniprot No.：
  • 别名：
    PC11X_HUMAN; PCDH-X; PCDH11; PCDH11X; PCDHX; PPP1R119; Protein phosphatase 1 regulatory subunit 119; Protocadherin 11X; Protocadherin on the X chromosome; Protocadherin-11; Protocadherin-11 X-linked; Protocadherin-S
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potential calcium-dependent cell-adhesion protein.
  • 基因功能参考文献：
    1. PCDH11X, expressed in brain is implicated in cell-cell communication, verbal ability, cerebral asymmetry, and dendritic synaptic plasticity, may be regarded as a new candidate gene for dyslexia. PMID: 24591081
    2. PCDH11X expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. PMID: 22744706
    3. the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens PMID: 23600975
    4. our data...failed to confirm the association between PCDH11X polymorphisms and late-onset Alzheimer's disease PMID: 21276771
    5. An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected. PMID: 20523261
    6. PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population. PMID: 20707987
    7. association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy PMID: 20555150
    8. The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. PMID: 19859901
    9. By confirming the suspected lack of X-Y homologous status for PCDH11 in non-human primates, our results reinforce the hypothesis of a hominid-specific role for this gene in brain development PMID: 16825765
    10. We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X PMID: 19125366
    11. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. PMID: 19136949
    12. This paper proposes that the PCDH11X/Y gene pair generates epigenetic diversity relating to the species capacity for language including predisposition to psychosis. PMID: 18502103
    13. a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language PMID: 16874762

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.
  • 数据库链接：

    HGNC: 8656

    OMIM: 300246

    KEGG: hsa:27328

    STRING: 9606.ENSP00000362186

    UniGene: Hs.655673