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  4. Recombinant Human Protein phosphatase 1G (PPM1G)

Recombinant Human Protein phosphatase 1G (PPM1G)

  • 中文名称：
    人PPM1G重组蛋白
  • 货号：
    CSB-YP018494HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPM1G重组蛋白
  • 货号：
    CSB-EP018494HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPM1G重组蛋白
  • 货号：
    CSB-EP018494HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPM1G重组蛋白
  • 货号：
    CSB-BP018494HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPM1G重组蛋白
  • 货号：
    CSB-MP018494HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPM1G
  • Uniprot No.：
  • 别名：
    MGC1675; MGC2870; OTTHUMP00000123426; PP2C; PP2C gamma; PP2C-gamma; PP2CG; PP2Cgamma; PPM1G; PPM1G_HUMAN; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G; Protein phosphatase 2 catalytic subunit gamma isoform; Protein phosphatase 2C gamma isoform ; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium dependent 1 gamma; Protein phosphatase magnesium-dependent 1 gamma; Protein phosphatase Mg2+/Mn2+ dependent 1G
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-546
  • 氨基酸序列
    GAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. PMID: 26324325
    2. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder. PMID: 25982659
    3. PPM1G inactivates monomeric WWP2 and promotes the assembly of WWP2-WWP1 heterodimeric complex. PMID: 25071155
    4. PPM1G dephosphorylates the P-TEFb kinase T loop to disassemble the 7SK snRNP. PMID: 24316072
    5. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1. PMID: 23814053
    6. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage PMID: 22361354
    7. The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner. PMID: 17054950
    8. Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. PMID: 17074886
    9. PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1. PMID: 17572683
    10. an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex PMID: 17984321
    11. PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway. PMID: 19538940
    12. Functional study of the mouse homolog PMID: 9271424

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  • 亚细胞定位：
    Cytoplasm. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 组织特异性：
    Widely expressed. Most abundant in testis, skeletal muscle, and heart.
  • 数据库链接：

    HGNC: 9278

    OMIM: 605119

    KEGG: hsa:5496

    STRING: 9606.ENSP00000264714

    UniGene: Hs.643951