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  4. Recombinant Human Protein naked cuticle homolog 1 (NKD1)

Recombinant Human Protein naked cuticle homolog 1 (NKD1)

  • 中文名称：
    人NKD1重组蛋白
  • 货号：
    CSB-YP853369HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NKD1重组蛋白
  • 货号：
    CSB-EP853369HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NKD1重组蛋白
  • 货号：
    CSB-EP853369HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NKD1重组蛋白
  • 货号：
    CSB-BP853369HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NKD1重组蛋白
  • 货号：
    CSB-MP853369HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    NKD1; NKD; PP7246; Protein naked cuticle homolog 1; Naked-1; hNkd; hNkd1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-470
  • 氨基酸序列
    GKLHSKPAA VCKRRESPEG DSFAVSAAWA RKGIEEWIGR QRCPGGVSGP RQLRLAGTIG RSTRELVGDV LRDTLSEEEE DDFRLEVALP PEKTDGLGSG DEKKMERVSE PCPGSKKQLK FEELQCDVSM EEDSRQEWTF TLYDFDNNGK VTREDITSLL HTIYEVVDSS VNHSPTSSKM LRVKLTVAPD GSQSKRSVLV NQADLQSARP RAETKPTEDL RSWEKKQRAP LRFQGDSRLE QSGCYHHCVD ENIERRNHYL DLAGIENYTS QFGPGSPSVA QKSELPPRTS NPTRSRSHEP EAIHIPHRKP QGVDPASFHF LDTPIAKVSE LQQRLRGTQD GSKHFVRSPK AQGKSVGVGH VARGARNKPP LGPAIPAVSP SAHLAASPAL LPSLAPLGHK KHKHRAKESQ QGCRGLQAPL ASGGPVLGRE HLRELPALVV YESQAGQPVQ RHEHHHHHEH HHHYHHFYQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
  • 基因功能参考文献：
    1. the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway. PMID: 29115501
    2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells. PMID: 27231134
    3. HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression. PMID: 28292020
    4. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
    5. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia. PMID: 28443469
    6. Low NKD1 expression is associated with hepatocellular carcinoma. PMID: 27507614
    7. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. PMID: 28032380
    8. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer. PMID: 26097589
    9. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC PMID: 21599923
    10. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling PMID: 19956716

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  • 亚细胞定位：
    Cell membrane. Cytoplasm.
  • 蛋白家族：
    NKD family
  • 组织特异性：
    Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
  • 数据库链接：

    HGNC: 17045

    OMIM: 607851

    KEGG: hsa:85407

    STRING: 9606.ENSP00000268459

    UniGene: Hs.187578