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  4. Recombinant Human Protein FRG2 (FRG2)

Recombinant Human Protein FRG2 (FRG2)

  • 货号：
    CSB-YP720715HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP720715HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP720715HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP720715HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP720715HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FRG2
  • Uniprot No.：
  • 别名：
    FRG2; FRG2A; Protein FRG2; FSHD region gene 2 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MGKGNEDSDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KEKGKTAFSH SSEKHIQRQG SEPNPNKENS EETKLKAGNS TAGSEPESSS YRENCRKRKM SSKDSCQDTA GNCPEKECSL SLNKKSRSST AVHNSEIQET CDAHHRGHSR ACTGHSKRHR SRALGVQTPS IRKSLVTSVR AMSEAVYQDL AQVWAQQIHS PLTCEQLTLL TRLRGPLCAQ VQTLYSMATQ AAYVFPAESW LVPATLPGPG ESALDREAHP FPGQEITETV SGSDEAKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Study showed that the variability in clinical severity of facioscapulohumeral muscular dystrophy in FSHD1 and FSHD2 individuals is dependent on individual differences in susceptibility to D4Z4 hypomethylation. PMID: 25256356
    2. new insights into the gene deregulation characterizing both FSHD-1 and FSHD-2, in which miRNAs may play a role PMID: 21695143
    3. Clinically, patients with FSHD2 are indistinguishable from patients with FSHD1. The present data suggest that FSHD1 and FSHD2 are the result of the same pathophysiologic process. PMID: 20975055
    4. FRG2 is upregulated in differentiating myoblast cultures of autosomal dominant facioscapulohumeral muscular dystrophy patients. PMID: 15520407
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FRG2 family
  • 组织特异性：
    Expression is undetectable in all tissues tested except for differentiating myoblasts of FSHD patients, which display low, yet distinct levels of expression, partly from FRG2, but predominantly originating from its homolog on chromosome 10.
  • 数据库链接：

    HGNC: 19136

    OMIM: 609032

    KEGG: hsa:448831

    STRING: 9606.ENSP00000368039

    UniGene: Hs.626907