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  4. Recombinant Human Prokineticin-2 (PROK2)

Recombinant Human Prokineticin-2 (PROK2)

  • 中文名称：
    人PROK2重组蛋白
  • 货号：
    CSB-YP875716HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PROK2重组蛋白
  • 货号：
    CSB-EP875716HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PROK2重组蛋白
  • 货号：
    CSB-EP875716HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PROK2重组蛋白
  • 货号：
    CSB-BP875716HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PROK2重组蛋白
  • 货号：
    CSB-MP875716HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PROK2
  • Uniprot No.：
  • 别名：
    BV8; Bv8 homolog ; MIT1 ; PK2; PROK2; PROK2_HUMAN; Prokineticin-2; Protein Bv8 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-129
  • 氨基酸序列
    AVI TGACDKDSQC GGGMCCAVSI WVKSIRICTP MGKLGDSCHP LTRKNNFGNG RQERRKRKRS KRKKEVPFFG RRMHHTCPCL PGLACLRTSF NRFICLAQK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
  • 基因功能参考文献：
    1. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. PMID: 27887936
    2. Prokineticin-2 is correlated with various cardiometabolic risk factors. PMID: 26728949
    3. Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] PMID: 26574895
    4. Suggest PROK2 as an angiogenic growth factor in colorectal cancer. PMID: 26317645
    5. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance PMID: 25531638
    6. PROK2 significantly increased in human fetal ovary across gestation. PMID: 26192875
    7. EG-VEGF, BV8, and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis lungs compared with controls. PMID: 26047640
    8. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes PMID: 24002956
    9. PROK2 signaling in humans is not required for central circadian pacemaker function. PMID: 24423319
    10. A novel role of BV8 in promoting oncogenesis intrinsic to malignant cells of myeloid origin. PMID: 23548897
    11. We could not implicate the ligand PROK2 in congenital hypopituitarism and septo-optic dysplasia. PMID: 23386640
    12. Three PROKR2 mutations previously described in Kallmann syndrome and one new PROK2 mutation were found in patients with isolated congenital anosmia. PMID: 23082007
    13. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. PMID: 22528488
    14. Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors. PMID: 22050240
    15. Patients with this genetic form of Kallmann syndrome have been reported to have a possible increased prevalence of obesity and sleep disorders, which may be related to the role of PROK2 in food intake and circadian rhythms (Review) PMID: 20389090
    16. Review. Role of prokineticins in inflammatory and contractile pathways at parturition in humans. PMID: 20172976
    17. Male patients carrying biallelic mutations in PROK2 or PROKR2 have a less variable and on average a more severe reproductive phenotype than patients carrying monoallelic mutations in these genes. PMID: 20022991
    18. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. PMID: 12024206
    19. Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis PMID: 12604792
    20. Paracrine role for the PKs and their receptors in endometrial vascular function. PMID: 15126578
    21. potentially modulates growth, survival, and function of cells of the innate and adaptive immune systems, possibly through autocrine or paracrine signaling mechanisms PMID: 15548611
    22. study demonstrated that prokineticin 1 and 2 and their receptors are expressed in human prostate and that their levels increased with prostate malignancy PMID: 16763065
    23. These findings reveal that insufficient prokineticin-signaling through PROKR2 leads to abnormal development of the olfactory system and reproductive axis in man. PMID: 17054399
    24. Homozygous loss-of-function PROK2 mutations cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism PMID: 17959774
    25. The identification of PROK2 biallelic mutations, that is, a missense mutation, p.R73C, and a frameshift mutation, c.163delA, in two out of 273 patients presenting as sporadic cases, is reported. PMID: 18285834
    26. PK2/Bv8 expression decreases as the liver evolves towards cancer and does not correlate with HCC angiogenesis PMID: 18300343
    27. Loss-of-function mutations in PROK2 and PROKR2 underlie both Kallmann syndrome (KS) and normosmic idiopathic hypogonadotropic hypogonadism (IHH). PMID: 18559922
    28. Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. PMID: 18682503
    29. no mutations found in Kallmann syndrome PMID: 18723471
    30. Bv8 expression is regulated by several cytokines in a cell type-specific fashion PMID: 19336519

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  • 相关疾病：
    Hypogonadotropic hypogonadism 4 with or without anosmia (HH4)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    AVIT (prokineticin) family
  • 组织特异性：
    Expressed in the testis and, at low levels, in the small intestine.
  • 数据库链接：

    HGNC: 18455

    OMIM: 607002

    KEGG: hsa:60675

    STRING: 9606.ENSP00000295619

    UniGene: Hs.528665