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  4. Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4)

Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (ALKBH4)

  • 中文名称：
    Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4(ALKBH4),Yeast
  • 货号：
    CSB-YP885759HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4(ALKBH4),Yeast
  • 货号：
    CSB-EP885759HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4(ALKBH4),Yeast
  • 货号：
    CSB-EP885759HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4(ALKBH4),Yeast
  • 货号：
    CSB-BP885759HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH4(ALKBH4),Yeast
  • 货号：
    CSB-MP885759HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ALKBH4
  • Uniprot No.：
  • 别名：
    2010004B12Rik; ABH4; Abj4; AlkB; alkylation repair homolog 4 (E. coli); ALKB4_HUMAN; Alkbh4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-302
  • 氨基酸序列
    AAAAAETPE VLRECGCKGI RTCLICERQR GSDPPWELPP AKTYRFIYCS DTGWAVGTEE SDFEGWAFPF PGVMLIEDFV TREEEAELVR LMDRDPWKLS QSGRRKQDYG PKVNFRKQKL KTEGFCGLPS FSREVVRRMG LYPGLEGFRP VEQCNLDYCP ERGSAIDPHL DDAWLWGERL VSLNLLSPTV LSMCREAPGS LLLCSAPSAA PEALVDSVIA PSRSVLCQEV EVAIPLPARS LLVLTGAARH QWKHAIHRRH IEARRVCVTF RELSAEFGPG GRQQELGQEL LRIALSFQGR PV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
  • 基因功能参考文献：
    1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
    2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
    3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
  • 蛋白家族：
    AlkB family
  • 组织特异性：
    Widely expressed, with highest expression in pancreas, ovary and spleen.
  • 数据库链接：

    HGNC: 21900

    OMIM: 613302

    KEGG: hsa:54784

    STRING: 9606.ENSP00000292566

    UniGene: Hs.658598