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  4. Recombinant Human Probable ATP-dependent RNA helicase DDX41 (DDX41)

Recombinant Human Probable ATP-dependent RNA helicase DDX41 (DDX41)

  • 中文名称：
    Recombinant Human Probable ATP-dependent RNA helicase DDX41(DDX41),Yeast
  • 货号：
    CSB-YP891940HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Probable ATP-dependent RNA helicase DDX41(DDX41),Yeast
  • 货号：
    CSB-EP891940HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Probable ATP-dependent RNA helicase DDX41(DDX41),Yeast
  • 货号：
    CSB-EP891940HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Probable ATP-dependent RNA helicase DDX41(DDX41),Yeast
  • 货号：
    CSB-BP891940HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Probable ATP-dependent RNA helicase DDX41(DDX41),Yeast
  • 货号：
    CSB-MP891940HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DDX41
  • Uniprot No.：
  • 别名：
    2900024F02Rik ; AA958953; ABS; AI324246; Ddx41; DDX41_HUMAN; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DEAD box protein 41; DEAD box protein abstrakt; DEAD box protein abstrakt homolog; EC 3.6.1.-; fb92e02; MGC55896; MGC8828; Probable ATP-dependent RNA helicase DDX41; Putative RNA helicase; wu:fb92e02 ; zgc:55896
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-622
  • 氨基酸序列
    MEESEPERKR ARTDEVPAGG SRSEAEDEDD EDYVPYVPLR QRRQLLLQKL LQRRRKGAAE EEQQDSGSEP RGDEDDIPLG PQSNVSLLDQ HQHLKEKAEA RKESAKEKQL KEEEKILESV AEGRALMSVK EMAKGITYDD PIKTSWTPPR YVLSMSEERH ERVRKKYHIL VEGDGIPPPI KSFKEMKFPA AILRGLKKKG IHHPTPIQIQ GIPTILSGRD MIGIAFTGSG KTLVFTLPVI MFCLEQEKRL PFSKREGPYG LIICPSRELA RQTHGILEYY CRLLQEDSSP LLRCALCIGG MSVKEQMETI RHGVHMMVAT PGRLMDLLQK KMVSLDICRY LALDEADRMI DMGFEGDIRT IFSYFKGQRQ TLLFSATMPK KIQNFAKSAL VKPVTINVGR AGAASLDVIQ EVEYVKEEAK MVYLLECLQK TPPPVLIFAE KKADVDAIHE YLLLKGVEAV AIHGGKDQEE RTKAIEAFRE GKKDVLVATD VASKGLDFPA IQHVINYDMP EEIENYVHRI GRTGRSGNTG IATTFINKAC DESVLMDLKA LLLEAKQKVP PVLQVLHCGD ESMLDIGGER GCAFCGGLGH RITDCPKLEA MQTKQVSNIG RKDYLAHSSM DF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. Results show that the DDX41 DEAD domain recognizes both double-stranded DNA (dsDNA) and cyclic dinucleotides (CDN) at the same binding site. A structural comparison between the open and closed forms of the DDX41 DEAD domain revealed the structural rearrangement in the N-terminal region, which drastically changes the conformation of the ATP-binding site. PMID: 27721487
    2. analysis suggests that rather than establishing a causal Mendelian link between DDX41 germline LOF variants and MDS/AML it is appropriate to consider these as genetic risk factors PMID: 27133828
    3. Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia. PMID: 26944477
    4. Structural and functional analyses of human DDX41 DEAD domain. PMID: 27928732
    5. DDX41 mutations lead to development of high-risk myelodysplastic syndrome.(review) PMID: 28547672
    6. An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (MDS/AML) patients. PMID: 27502187
    7. data demonstrate that DDX41 suppresses p21 translation without disturbing the function of p53 to directly induce p21 mRNA expression, this process indirectly requires p53, perhaps in the form of another p53 target gene or as a still undefined posttranscriptional function of p53. PMID: 28348086
    8. This study uncovered a pathogenic role of p.R525H DDX41 in the slow growth rate of tumor cells. Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML. PMID: 27174803
    9. This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations. PMID: 26712909
    10. corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing PMID: 25920683
    11. results suggest a mechanism whereby c-di-GMP and c-di-AMP are detected by DDX41, which forms a complex with STING to signal to TBK1-IRF3 and activate the interferon response PMID: 23142775
    12. DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA. PMID: 21892174
    13. The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 suggesting that PX domains may also participate in protein-protein interaction. PMID: 15690390

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  • 相关疾病：
    Myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DEAD box helicase family, DDX41 subfamily
  • 数据库链接：

    HGNC: 18674

    OMIM: 608170

    KEGG: hsa:51428

    STRING: 9606.ENSP00000422753

    UniGene: Hs.484288