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  4. Recombinant Human Pro-MCH (PMCH)

Recombinant Human Pro-MCH (PMCH)

  • 货号：
    CSB-YP324927HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP324927HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP324927HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP324927HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP324927HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PMCH
  • Uniprot No.：
  • 别名：
    PMCH; MCHPro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid; NGE; Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine; NEI; Neuropeptide E-I); Melanin-concentrating hormone; MCH)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-165
  • 氨基酸序列
    ILLSASKSI RNLDDDMVFN TFRLGKGFQK EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
  • 基因功能参考文献：
    1. MCH is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis; evidence suggests that, in the reproductive context, MCH is a modulator rather than a primary regulator. PMID: 23884861
    2. Cerebrospinal fluid (CSF) levels were measured in 33 patients with Alzheimer's disease (AD) and 33 healthy subjects, to investigate the role of MCH and HCRT-1 in AD. PMID: 23667582
    3. the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala, are reported. PMID: 23462990
    4. Melanin-concentrating hormone (MCH) neurons of human hypothalamus, as well as the MCH neurons of mouse hypothalamus, contain IL-6Ralpha. PMID: 22295972
    5. PMCH mRNA expression level was increased 1.85 times (P < 0.01) in vitiligo uninvolved skin and 5.36 times (P < 0.01) in involved skin compared to healthy control skin. PMID: 20888736
    6. Melanin-concentrating hormone is expressed and functional in human skin PMID: 12176038
    7. RT-PCR analysis revealed a low expression of prepro-MCH and MCH receptor 1 (MCHR1) but not of MCHR2 transcript in tissular and peripheral blood immune cells PMID: 12220661
    8. Review. Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH-R1 antagonists can probe additional functions of the peptide, both in the brain and in the peripheral nervous system. PMID: 12885269
    9. Serum levels could serve as useful peripheral markers of changes in energy homeostasis. PMID: 15546902
    10. hMCH increased water intake independent of food intake. It significantly increased both sucrose solution and food intake. PMID: 15870910
    11. Single nucleotide polymorphisms in pro-melanin-concentrating hormone may be associated with obesity and a greater body mass index in olanzapine-treated schizophrenic patients PMID: 17541984
    12. expression of PMCH by activated Th2 cells in vivo may directly link allergic inflammation to energy homeostasis and may contribute to the association between asthma and obesity PMID: 17640905
    13. The total number of hypocretin-1 neurons was significantly reduced by 30% in HD brains (P = 0.015), while the total number of MCH neurons was not significantly altered (P = 0.100). PMID: 18498421
    14. MCH has a role in inflammatory processes in the intestine PMID: 18650383

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Melanin-concentrating hormone family
  • 组织特异性：
    Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood
  • 数据库链接：

    HGNC: 9109

    OMIM: 176795

    KEGG: hsa:5367

    STRING: 9606.ENSP00000332225

    UniGene: Hs.707990