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  4. Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), partial

Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), partial

  • 货号：
    CSB-YP613501HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP613501HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP613501HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP613501HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP613501HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GALNT3
  • Uniprot No.：
  • 别名：
    DKFZp686C10199; EC 2.4.1.41; GalNAc T3; GalNAc transferase 3; GalNAc-T3; GalNAcT3; GALNT3; GALT3_HUMAN; HFTC; HHS; MGC61909; OTTHUMP00000204915; OTTHUMP00000204919; Polypeptide GalNAc transferase 3; Polypeptide GalNAc transferase T3; Polypeptide N acetylgalactosaminyltransferase 3; Polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3; ppGaNTase 3; Protein UDP acetylgalactosaminyltransferase 3; Protein-UDP acetylgalactosaminyltransferase 3; RP23-306G16.2; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 3 ; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 3 (GalNAc T3); UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.
  • 基因功能参考文献：
    1. GalNAc-T3 was highly expressed by motile spermatozoa and the expression correlated positively with the classical semen parameters. PMID: 30262754
    2. Study shows that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis. PMID: 29516288
    3. Giantin-knockout zebrafish exhibit hyperostosis and ectopic calcium deposits, recapitulating phenotypes of hyperphosphatemic familial tumoral calcinosis, a disease caused by mutations in GALNT3. These data reveal a new feature of Golgi homeostasis: the ability to regulate glycosyltransferase expression to generate a functional proteoglycome. PMID: 29093022
    4. study supports an essential role of GALNT3 in Epithelial ovarian cancer dissemination, including its implication in modulating post-translational modifications and EOC metabolism PMID: 27095597
    5. The acetylated residues on ppGalNAc-T3 function as control points for enzyme activity, and high level of GlcNAc glycosides promote a synergistic regulatory mechanism, leading to a metabolically disordered state. PMID: 28672761
    6. This study identified GALNT3 as a novel gene that rendered patients susceptible to coronary artery disease (CAD), and the A allele of a disease-associated variant rs4621175 linked reduced CAD risk through decreased GALNT3 expression. PMID: 28453302
    7. Study indicates that loss of GALNT3 occurs in poorly differentiated PDAC, which is associated with the increased aggressiveness and altered glycosylation of ErbB family proteins. PMID: 27187683
    8. GalNAc-T3 might play a role in the pathogenesis of early stage oral squamous cell carcinoma recurrence PMID: 26296622
    9. MGAT5 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. PMID: 25630622
    10. Two microRNAs (miRNAs), miR-17-3p and miR-221, which target GalNAc transferase 3 (GALNT3) mRNA, are rapidly downregulated in human alveolar basal epithelial cells during the early stage of influenza A virus infection. PMID: 26637460
    11. hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation PMID: 25249269
    12. Polymorphisms of rs1863196, rs6710518, rs4667492, rs1349321 and rs6721582 (GALNT3) are associated with bone mineral density.GALNT3 may play a role in genetic susceptibility to postmenopausal osteoporosis in Chinese womeh. PMID: 24045674
    13. Data are indicative for a strong oncogenic potential of the GALNT3 gene in advanced EOC and identify this transferase as a novel EOC biomarker. PMID: 24504219
    14. Our data suggest that GalNAc-T3 expression may be a useful indicator of tumor differentiation in thyroid carcinomas. PMID: 23659732
    15. we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes. PMID: 24038392
    16. GalNac transferase transgenic knock-out mice neurons have significantly increased rates of axon degeneration. PMID: 24431446
    17. N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with renal cell carcinomas. PMID: 23799843
    18. a novel homozygous missense mutation affecting highly conserved amino acids in GALNT3 in patients with hyperphosphatemic familial tumoral calcinosis PMID: 21347749
    19. GalNAc-T3 is likely involved in pancreatic carcinogenesis PMID: 21625220
    20. GALNT3 is associted with bone mineral density variation. PMID: 21533022
    21. Mutational analysis of FGF23 and GALNT3 in patients with hyperphosphatemia and clinical manifestations including tumoral calcinosis revealed novel homozygous mutations in GALNT3. PMID: 20358599
    22. The genetic predisposition to calcinosis and hyperostosis-hyperphosphataemia syndrome due to missense mutations in GALNT3 protein. PMID: 19830424
    23. N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers. PMID: 12232759
    24. the expression of GalNAc-T3 is associated with the differentiation and aggressiveness of ductal adenocarcinoma of the pancreas PMID: 14555840
    25. Low expression of GalNAc-T3 was associated with poorly differentiated tumor, poor pathologic stage, lymph node metastasis, and tumour recurrence in lung adenocarcinoma PMID: 14735190
    26. In gallbladder cancer, the presence of diffuse-type localization of GalNAc-T3 in the subserosal layer is correlated with aggressiveness of the diseases. PMID: 15041730
    27. mapped the gene underlying familial tumoral calcinosis to 2q24-q31.This region includes the gene GALNT3. Sequence analysis of GALNT3 identified biallelic deleterious mutations, suggesting defective post-translational modification. PMID: 15133511
    28. GalNAc-T3 may play a positive role in the process of carcinogenesis and progression in esophageal squamous cell carcinoma (SCC) and functional inhibition of GalNAc-T3 may be effective for the prevention and treatment of esophageal SCC. PMID: 15860931
    29. GalNAc-T3 selectively directs O-glycosylation in a subtilisin-like proprotein convertase recognition sequence motif, which blocks processing of FGF23 PMID: 16638743
    30. Calcinosis presenting with eyelid calcifications due to novel missense mutations in GALNT3. PMID: 16940445
    31. mutation analyses of GALNT3 in a subject with hyperphosphatemic familial tumoral calcinosis and in his relatives; first report describing the simultaneous presence of two different stop codons in the coding sequence of the GALNT3 gene PMID: 17351710
    32. Extra hepatic bile duct carcinomas alter their GalNAc-T3 expression during tumor growth, and the difference in the expression pattern may be associated with lymph node metastasis. PMID: 17361208
    33. we have detected novel GALNT3 mutations that result in familial TC, and show that disturbed serum FGF23 concentrations are present in our TC cases PMID: 17853462
    34. study identified a Beninese family in which two brothers present Familial Tumoral Calcinosis caused by a homozygous A>T transversion at the acceptor splice site in intron 1 of the GALNT3 gene PMID: 18618993
    35. decreased GALNT3 expression in skin fibroblasts leads to increased expression of FGF7 and of matrix metalloproteinases, which have been previously implicated in the pathogenesis of ectopic calcification PMID: 18976705
    36. Mutations in the UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 (GALNT3) and fibroblast growth factor-23 (FGF23) genes have been described in tumoral calcinosis. PMID: 19411468

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  • 相关疾病：
    Tumoral calcinosis, hyperphosphatemic, familial (HFTC)
  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Resides preferentially in the trans and medial parts of the Golgi stack.
  • 蛋白家族：
    Glycosyltransferase 2 family, GalNAc-T subfamily
  • 组织特异性：
    Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney.
  • 数据库链接：

    HGNC: 4125

    OMIM: 211900

    KEGG: hsa:2591

    STRING: 9606.ENSP00000376465

    UniGene: Hs.170986