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  4. Recombinant Human Plasminogen activator inhibitor 1 RNA-binding protein (SERBP1)

Recombinant Human Plasminogen activator inhibitor 1 RNA-binding protein (SERBP1)

  • 中文名称：
    人SERBP1重组蛋白
  • 货号：
    CSB-YP839849HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SERBP1重组蛋白
  • 货号：
    CSB-EP839849HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SERBP1重组蛋白
  • 货号：
    CSB-EP839849HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SERBP1重组蛋白
  • 货号：
    CSB-BP839849HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SERBP1重组蛋白
  • 货号：
    CSB-MP839849HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SERBP1
  • Uniprot No.：
  • 别名：
    CGI 55; CHD3IP; Chromodomain helicase DNA binding protein 3 interacting protein; DKFZp564M2423; FLJ90489; HABP4L; PAI 1 mRNA binding protein; PAI RBP1; PAI-RBP1; PAI1 RNA-binding protein 1; PAIRB_HUMAN; PAIRBP1; Plasminogen activator inhibitor 1 RNA binding protein; Plasminogen activator inhibitor 1 RNA-binding protein; Serbp1; SERPINE1 mRNA binding protein 1; SERPINE1 mRNA-binding protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-408
  • 氨基酸序列
    PGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD PEAFPALA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation.
  • 基因功能参考文献：
    1. All these results suggested that miR-218/SERBP1 signal pathway could inhibit the malignant phenotype formation and that targeting this pathway may be a potential novel way for HCC therapeutics. PMID: 28369267
    2. Data indicate that serpine1 messenger RNA (mRNA) binding protein 1 (SERBP1) was identified as a downstream target of microRNA miR-26a-5p. PMID: 27449037
    3. SERBP1 is a component of the LRH-1 transcriptional complex. PMID: 26398198
    4. PAI-RBP1 expression level is higher in non-small lung cancer tissues than in normal tissues. PMID: 22373659
    5. Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
    6. The RNA-binding protein SERBP1 is abundantly expressed in human breast cancer and may represent a novel breast tumour marker with prognostic significance PMID: 23236990
    7. The RG-rich and RGG box of SERBP1 is asymmetrically dimethylated by PRMT1 and the modification affects protein interaction and intracellular localization of the protein. PMID: 22442049
    8. The 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases. PMID: 11972486
    9. Polymorphism of the PAI-1 gene promoter does not influence the development of AAA. However, the effect of PAI-1 genotype (5G5G) appears protective on survival following open aneurysm repair. PMID: 12027469
    10. We observed that CGI-55 localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies. PMID: 16679534
    11. Has two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by protein arginine-methyltransferase-1 (PRMT1). PMID: 16879614
    12. The presence of the genotype risk factors alone does not seem to be associated with the development of preeclampsia even in the severe presentation form. PAI-1 gene polymorphisms on the development of the preeclampsia was indicated. PMID: 16963292
    13. In ovarian cancer, PAI-RBP1 is significantly overexpressed in tumor epithelial cells, suggesting a biological role in tumor invasion and metastasis. Its expression is higher in advanced disease. PMID: 17698176
    14. This gene encodes a protein, PAI-RBP1, that binds to an RNA sequence (cyclic nucleotide responsive sequence, CRS) in the plasminogen activator-inhibitor (PAI-1) mRNA that confers cAMP regulation of mRNA stability. PMID: 11001948

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
  • 数据库链接：

    HGNC: 17860

    OMIM: 607378

    KEGG: hsa:26135

    STRING: 9606.ENSP00000360034

    UniGene: Hs.530412