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  4. Recombinant Human Plasma serine protease inhibitor (SERPINA5)

Recombinant Human Plasma serine protease inhibitor (SERPINA5)

  • 货号：
    CSB-YP021061HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021061HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021061HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021061HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021061HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Acrosomal serine protease inhibitor; IPSP; IPSP_HUMAN; PAI 3; PAI-3; PAI3; PCI; PCI-B; PLANH 3; PLANH3; Plasma serine protease inhibitor; Plasminogen activator inhibitor 3; Plasminogen activator inhibitor III; PROCI; Protein C inhibitor; Serpin A5; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5; Serpin peptidase inhibitor clade A member 5; Serpina5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-406
  • 氨基酸序列
    EMKKR VEDLHVGATV APSSRRDFTF DLYRALASAA PSQSIFFSPV SISMSLAMLS LGAGSSTKMQ ILEGLGLNLQ KSSEKELHRG FQQLLQELNQ PRDGFQLSLG NALFTDLVVD LQDTFVSAMK TLYLADTFPT NFRDSAGAMK QINDYVAKQT KGKIVDLLKN LDSNAVVIMV NYIFFKAKWE TSFNHKGTQE QDFYVTSETV VRVPMMSRED QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW LKMFKKRQLE LYLPKFSIEG SYQLEKVLPS LGISNVFTSH ADLSGISNHS NIQVSEMVHK AVVEVDESGT RAAAATGTIF TFRSARLNSQ RLVFNRPFLM FIVDNNILFL GKVNRP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
  • 基因功能参考文献：
    1. the snp rs1955656 in the SERPINA5 were associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock PMID: 28270177
    2. Data show that the methylation degree of five CpG sites significantly correlated with lower SERPINA5 expression levels. PMID: 29187436
    3. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer PMID: 27207655
    4. host protein C inhibitor expressed in mouse has a role in inhibiting tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability PMID: 25887633
    5. These findings highlight an important role of SERPINA5 in the regulation of migratory and metastatic potentials of HCC and suggest a potential application of SERPINA5 in cancer treatment. PMID: 24388360
    6. These results suggest that HIV resistance in some exposed patients is the result of a balance between downregulation of serine proteinases and upregulation of their inhibitors. PMID: 24928035
    7. A novel protein C inhibitor gene mutation in pediatric stroke patients after bone marrow transplantation. PMID: 23670045
    8. Decreased SERPINA5 expression due to DNA promoter methylation is associated with papillary thyroid carcinoma. PMID: 24222120
    9. the SERPINA5 gene, which codes for the protein C inhibitor involved in many biological processes including inflammation, may be a new susceptibility locus for PTC. PMID: 23520464
    10. One of the monomers, 52-kDa PCI, formed a stable complex with activated protein C, urokinase, plasma and tissue kallikrein, but the dimer species and 48-kDa PCI were inactive. PMID: 22206708
    11. the effects of N-glycans and the NH-terminus on a PCI function PMID: 22205989
    12. SerpinA5 expression is significantly reduced in advanced-stage serous borderline tumors and serous carcinomas. PMID: 21102419
    13. This study was undertaken to further understand the structural micro-heterogeneity of PCI. Individuals of two different ethnicities possess a similar PCI pattern, verifying that the micro-heterogeneity is conserved among humans. PMID: 21056543
    14. APC-PCI complex levels were higher in peripheral arterial disease patients than in controls, but did not predict the clinical outcome. PMID: 20409682
    15. function for PCI in innate immunity PMID: 20019810
    16. In men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0). PMID: 19765701
    17. PCI can up regulate TAFI activation by inhibiting the protein C activation. PCI may therefore be an important regulator in the balance between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of protein C. PMID: 11686324
    18. Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor. PMID: 11864713
    19. Protein C inhibitor regulates the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by these cells PMID: 14696115
    20. PCI may be involved in regulating key serine proteases involved in metastatic prostate disease PMID: 15878512
    21. exposure of oxidized PE and/or PS may be important for the local regulation of protein C inhibitor activity in vivo PMID: 17332248
    22. anti-angiogenic activity of PCI was strong as cleaved antithrombin, and slightly stronger than that of plasminogen activator inhibitor-1 and pigment epithelium-derived factor PMID: 17450526
    23. Patients with abdominal aortic aneurysm have increased thrombin generation reflected by an increase in the activated protein C-protein C inhibitor complex, which correlates with aneurysm size. PMID: 18184931
    24. In human renal tissues, PCI and urinary plasminogen activator colocalized in the cytoplasm of renal proximal tubular epithelial cells PMID: 18193533
    25. A crystallographic structure of the Michaelis complex of PCI, thrombin, and heparin to 1.6 A resolution, was determined. PMID: 18362344
    26. The heparin binding site of protein C inhibitor is protease-dependent. PMID: 18974053

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  • 亚细胞定位：
    Secreted, extracellular space. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
  • 蛋白家族：
    Serpin family
  • 组织特异性：
    Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets.
  • 数据库链接：

    HGNC: 8723

    OMIM: 601841

    KEGG: hsa:5104

    STRING: 9606.ENSP00000333203

    UniGene: Hs.159628