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  4. Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

  • 货号：
    CSB-YP619767HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP619767HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP619767HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP619767HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP619767HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    51 kDa FK506 binding protein 5; 51 kDa FK506 binding protein; 51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor associated immunophilin; 54 kDa progesterone receptor-associated immunophilin; AIG 6; AIG6; Androgen regulated protein 6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP 5; FKBP 51; FKBP 54; FKBP-5; FKBP-51; FKBP5; FKBP5_HUMAN; FKBP54; HSP90 binding immunophilin; HSP90-binding immunophilin; MGC111006; OTTHUMP00000016268; P54; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP5; Peptidylprolyl cis trans isomerase; PPIase; PPIase FKBP5; Ptg 10; Ptg10; Rotamase; T cell FK506 binding protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-457
  • 氨基酸序列
    MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1.
  • 基因功能参考文献：
    1. Study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness. PMID: 28975925
    2. Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD. PMID: 28198448
    3. We hypothesize a role for FKBP51 as a prognostic marker for MF and suggest an involvement of this immunophilin in deregulated NF-jB pathway of this CTCL. PMID: 28977697
    4. Trauma exposure shapes FKBP5 impact on schizophrenia. PMID: 27552816
    5. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking. PMID: 27709495
    6. Study found that DNA methylation levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM. PMID: 28961425
    7. study thus provides support for an association between specific FKBP5 genetic variants and MDD risk PMID: 27601205
    8. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. PMID: 29162173
    9. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking. PMID: 29162188
    10. FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. PMID: 29162190
    11. Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability. PMID: 28889074
    12. SNPs moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits PMID: 29466454
    13. In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder. PMID: 28025095
    14. It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. PMID: 28590587
    15. These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD). PMID: 28850857
    16. FKBP5 polymorphisms in combination with early life stress exposure predict higher insulin and glucose values in midlife. PMID: 27941579
    17. GxE interaction between child maltreatment and FKBP5 on dissociative symptoms in adolescence. PMID: 27760575
    18. Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms. PMID: 27485401
    19. This study demonstrated that FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex. PMID: 26805584
    20. A novel FKBP5 1V55L mutation is associated with Paget's disease in a Chinese family. Mutant FKBP51V55L promotes osteoclastogenesis. PMID: 28524179
    21. A negative correlation between basal levels of FKBP5 methylation and serum cortisol was observed. PMID: 28875708
    22. Study found an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. Data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene. PMID: 26801675
    23. This study demonstrated suggest that FKBP5 in the GR pathway may be a point of vulnerability to early-life adversity, as seen in this group of non-traumatized young adults. PMID: 26632991
    24. Psychological stress impaired immediate recall in rs1360780, rs3800373 and rs9296158 allele carriers. PMID: 28002634
    25. Association of FKBP5 haplotype with risk of suicide attempt. PMID: 27030168
    26. This study provides initial evidence that the risk alleles of the FKBP5 polymorphism are associated with different resting-state activity in a frontotemporal-parietal network, and may point to mechanisms underpinning high-risk carriers' vulnerability to severe stress reactions. PMID: 27754486
    27. This review showed a significant genetic association in most studies in FKBP5 with a high rate of attempted suicide. PMID: 27638035
    28. Associations between the FKBP5 SNPs, exposure to violence and anxiety in females. PMID: 27448712
    29. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. PMID: 27315459
    30. FKBP51 is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (but not FKBP52) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria. PMID: 27233944
    31. The results show that the presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes PMID: 27421688
    32. The role of FKBP51 in intracellular pathways involved in adaptation is summarized. PMID: 27374865
    33. we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). There exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype. PMID: 27196697
    34. LIF and FKBP51 expression in epithelial cells were the most interesting markers of Airway epithelial cells dysfunction/response to corticosteroid treatment. PMID: 28493984
    35. The data of this study show a significant increase in DNA methylation of FKBP5 in peripheral blood mononuclear cells of major depressive disorder patients. PMID: 28246044
    36. Knockdown of FKBP51 alleviates neuropathic pain via inhibiting the NF-kappaB signaling in chronic constriction injury rat model. PMID: 28629826
    37. we sought to extend prior GxE findings by examining the relation of four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs947008), childhood abuse, and lifetime PTSD symptom severity. Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples . SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity PMID: 27078785
    38. Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling. PMID: 27086273
    39. Associations between FKBP5 genotype and neurodevelopment; potential interaction between FKBP5 genotype and stress experiences (NICU) in preterm infants. PMID: 28247564
    40. The main finding in this study is that Holocaust survivors and their offspring have methylation changes on the same site in a functional intronic region of the FKBP5 gene, a GR-binding sequence in intron 7. PMID: 26410355
    41. FKBP51 improves the ability of stromal androgen receptor to predict prostate cancer-specific mortality. PMID: 27718274
    42. the interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect PMID: 27389186
    43. FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. PMID: 28401840
    44. Specific variations in FKBP5 gene increased the risk of attempted suicide. PMID: 28030643
    45. FKBP5 variations in combination early life stress predict more pronounced depressive symptoms in midlife. PMID: 26740367
    46. Our results confirm that the rs1360780 locus alters FKBP5 expression and further that in trans-fashion this locus affects the expression of other glucocorticoid-regulated genes after a glucocorticoid challenge. The CT exposure appears to be essential for trans-effects of rs1360780 on glucocorticoid-regulated genes. PMID: 27648526
    47. findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation. PMID: 27334923
    48. FKBP51 positively controls cell motility by promoting RhoA and ROCK activation, thus revealing a novel role for FKBP51 in cytoskeletal rearrangement and cell migration and invasion. PMID: 28032931
    49. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells. PMID: 27013342
    50. we propose tumor tissue expression of FKBP51 protein as a reliable prognostic marker for OSCC tumors. PMID: 28218707

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Widely expressed, enriched in testis compared to other tissues.
  • 数据库链接：

    HGNC: 3721

    OMIM: 602623

    KEGG: hsa:2289

    STRING: 9606.ENSP00000338160

    UniGene: Hs.407190