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  4. Recombinant Human Paired box protein Pax-2 (PAX2)

Recombinant Human Paired box protein Pax-2 (PAX2)

  • 货号：
    CSB-YP017488HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017488HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017488HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017488HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017488HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PAX2
  • Uniprot No.：
  • 别名：
    PAX2; Paired box protein Pax-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-417
  • 氨基酸序列
    MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT PDGAGTGVTA PGHTIVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK RKRDEVEVYT DPAHIRGGGG LHLVWTLRDV SEGSVPNGDS QSGVDSLRKH LRADTFTQQQ LEALDRVFER PSYPDVFQAS EHIKSEQGNE YSLPALTPGL DEVKSSLSAS TNPELGSNVS GTQTYPVVTG RDMASTTLPG YPPHVPPTGQ GSYPTSTLAG MVPGSEFSGN PYSHPQYTAY NEAWRFSNPA LLSSPYYYSA APRGSAPAAA AAAYDRH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
  • 基因功能参考文献：
    1. Our data suggested that high expression of PAX2 could be associated with better survival in estrogen receptor positive tamoxifen-treated breast carcinoma patients. PMID: 29857823
    2. During the ensuing weeks, the PAX2/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium PMID: 28918284
    3. PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 PMID: 27764784
    4. This case unravels a previously unrecognized phenotype of camptodactyly due to a significant skeletal deformity of Papillorenal syndrome with a heterogeneous PAX2 mutation of hexanucleotide duplication. PMID: 29054766
    5. Mutant p53 and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death. PMID: 27991925
    6. The polymorphism rs12266644 of PAX2 might be a risk factor for mullerian duct anomalies in Chinese Han females PMID: 27722936
    7. PAX2, PAX8, CDX2 immunostains was preformed to the TMA slides. PMID: 26797858
    8. we demonstrated that miR-497 is decreased in human ovarian cancer tissues and cells, and acts as a tumor suppressor. We also confirmed PAX2 is a target gene of miR-497 PMID: 27513319
    9. Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE. PMID: 26972711
    10. PAX2 and PAX5 are useful biomarker in the differential diagnosis of lung cancer PMID: 26823795
    11. a substantial minority of solitary fibrous tumors express nuclear PAX8 and PAX2 PMID: 26404914
    12. PAX2 gene silencing can significantly inhibit the process of epithelial-mesenchymal transition (EMT) of renal tubular cells in rats with advanced fibrosis. PMID: 27324546
    13. The results of this study identify several new mutations of PAX2, and sequence variants in four additional genes, including a novel potentially pathogenic mutation in KIF26B, which may play a role in the pathogenesis of Renal Coloboma Syndrome. PMID: 26571382
    14. data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 and PAX5 PMID: 25500505
    15. Homozygosity for the risk alleles of RET and PAX2 was not seen in the late onset group in primary hyperoxaluria type 1 patients. PMID: 25854853
    16. PAX2 and PAX8 are useful biomarker in the differential diagnosis of ovarian serous and mucinous tumors PMID: 24992169
    17. The 798C>T/909A>C PAX2 genotype did not increase the susceptibility to HenochSchonlein purpura (HSP), but it was likely to increase the susceptibility of kidney involvement in HSP patients. PMID: 25385517
    18. Novel PAX2 targets included multiple genes encoding proteins with predicted functions in the epididymis epithelium. PMID: 25180270
    19. Results showed that PAX2 expression is significantly overexpressed in esophageal squamous cell carcinoma tissues and IL-5 is identified as PAX2's effector for metastasis. PMID: 25613757
    20. Report increased Pax2 expression in the ureter epithelium of children with vesicoureteric reflux. PMID: 25912758
    21. Pax2 may play a role in kidney development by regulating the expression of TBX1. PMID: 25106525
    22. Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin. PMID: 25279712
    23. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    24. PAX2 was strongly positive in all alveolar rhabdomyosarcomas and in two-thirds of the kidney clear cell sarcomas, and displayed variable expression in one-half of the embryonal rhabdomyosarcomas. PMID: 24897005
    25. study suggests an association between PAX2 gene polymorphisms and the development of vesicoureteral reflux, but not with ureteropelvic junction obstruction and multicystic dysplastic kidney PMID: 24633556
    26. study, for the first time, links PAX2-null with proliferating fetal and adult oviductal cells undergoing basal and ciliated differentiation and shows that this expression state is maintained in high-grade serous cancer precursors PMID: 25130537
    27. PAX2 promotes cancer cell growth in androgen-independent prostate cancer by regulating androgen receptor gene expression through an epigenetic mechanism. PMID: 25132193
    28. Exome sequencing in an index family with dominant FSGS revealed a nonconservative, disease-segregating variant in the PAX2 gene. Sequencing in probands of a familial FSGS cohort revealed seven rare and private heterozygous SNPs (4% of individuals). PMID: 24676634
    29. cotransfection of Pax2 and Math1 strongly stimulates in situ hair cell regeneration in neomycin-damaged cochlear explants. PMID: 24141260
    30. Pax-2 expression might be used as an ancillary tool to discriminate chromophobe renal cell tumour from oncocytomas with overlapping morphological features. PMID: 23890189
    31. Case Report: sporadic renal hemangioblastoma expressing PAX2. PMID: 24040464
    32. other genes and/or locus control regions regulating PAX2 may be involved in the pathogenesis of PAX2 mutation-negative cases of RCS. PMID: 23756089
    33. PAX2 and PAX8 are valuable diagnostic markers for metastatic mullerian carcinomas and renal cell carcinoma in effusion cytology PMID: 24334997
    34. PAX2 and napsin A have high specificity but low sensitivity and only have limited value in the differential diagnosis of mesotheliomas and renal cell carcinomas PMID: 23503645
    35. Report high rate of mutations in PAX2 genes known to be involved in monogenic syndromic Congenital anomalies of the kidney and urinary tract. PMID: 23539225
    36. miR-1915 and miR-1225-5p regulated the expression of important markers of renal progenitors, such as CD133 and PAX2, and important genes involved in the repair mechanisms of adult renal progenitor cells, such as TLR2. PMID: 23861881
    37. These data suggest that in difficult diagnostic cases both PAX2 and mesothelin immunohistochemical study may be useful in discriminating between PMRCC and primary pancreatic carcinoma. PMID: 24344503
    38. Immunostains for PAX2 and PAX8 are useful in the detection of nephrogenic adenomas and particularly unveil those nephrogenic adenomas with flat pattern. PMID: 23328975
    39. PAX2 has little practical value in the diagnosis of peritoneal epithelioid mesotheliomas PMID: 23196794
    40. Our data suggested that PAX2 hyper-expression promotes the development of the metastatic state in prostate cancer cells, presumably through upregulating the expression of cell membrane proteins. PMID: 23765687
    41. Cryptorchidism-associated papillorenal syndrome/PAX2 mutation has not been reported. PMID: 23686327
    42. PAX2 is effective in discriminating cervical adenocarcinoma in situ from benign endocervical glandular epithelium PMID: 23202787
    43. PAX2 gene is pivotal in kidney development and it is implicated in the pathogenesis of renal interstitial fibrosis (RIF) and glomerulosclerosis (GS). PMID: 23137159
    44. PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells. PMID: 23135283
    45. cross-talk between p53 and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment PMID: 22984579
    46. investigation of expression of PAX2 and PAX8 in renal biopsy samples as diagnostic markers in the differential diagnosis of various types of primary and secondary renal cell carcinomas PMID: 23194047
    47. PAX-2, PAX-8, and hKIM-1 should be used cautiously in distinguishing renal cell carcinoma from nonseminomatous germ cell neoplasia and also adds to the growing list of nonrenal tumors that express these 3 markers. PMID: 22495365
    48. In both monozygotic twins with renal coloboma syndrome, a novel de novo mutation of PAX2 was detected, which leads to the substitution of a highly conserved cysteine (p.C52Y). PMID: 22660956
    49. Mutations in PAX2 may not be ac ommon cause of Mullerian Duct Abnormalities. PMID: 22683154
    50. These findings suggest that PAX2 may play a role in endometrial carcinogenesis. PMID: 22274645

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  • 相关疾病：
    Papillorenal syndrome (PAPRS); Focal segmental glomerulosclerosis 7 (FSGS7)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
  • 数据库链接：

    HGNC: 8616

    OMIM: 120330

    KEGG: hsa:5076

    STRING: 9606.ENSP00000396259

    UniGene: Hs.155644