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  4. Recombinant Human Oxysterol-binding protein-related protein 2 (OSBPL2)

Recombinant Human Oxysterol-binding protein-related protein 2 (OSBPL2)

  • 中文名称：
    人OSBPL2重组蛋白
  • 货号：
    CSB-YP884442HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OSBPL2重组蛋白
  • 货号：
    CSB-EP884442HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OSBPL2重组蛋白
  • 货号：
    CSB-EP884442HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OSBPL2重组蛋白
  • 货号：
    CSB-BP884442HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OSBPL2重组蛋白
  • 货号：
    CSB-MP884442HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OSBPL2
  • Uniprot No.：
  • 别名：
    FLJ20223; KIAA0772; MGC4307; MGC8342; ORP-2; ORP2; OSBL2_HUMAN; OSBP related protein 2; OSBP-related protein 2; OSBPL2; Oxysterol binding protein like 2; Oxysterol binding protein related protein 2; Oxysterol-binding protein-related protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-480
  • 氨基酸序列
    MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER PSQENGIQKH RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP LSFLQRITEY MEHVYLIHRA SCQPQPLERM QSVAAFAVSA VASQWERTGK PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFHSEGL NHDFLFHGSI YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVIIGKLWIE QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
  • 基因功能参考文献：
    1. point at a novel function of ORP2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation PMID: 29092904
    2. this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation. PMID: 29947926
    3. a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex PMID: 26992564
    4. This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness. PMID: 25759012
    5. Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss . PMID: 25077649
    6. ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking. PMID: 11861666
    7. Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol. PMID: 19224871

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  • 相关疾病：
    Deafness, autosomal dominant, 67 (DFNA67)
  • 亚细胞定位：
    Cytoplasm, cytosol. Lipid droplet. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    OSBP family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 15761

    OMIM: 606731

    KEGG: hsa:9885

    STRING: 9606.ENSP00000316649

    UniGene: Hs.473254