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  4. Recombinant Human Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Recombinant Human Oxidative stress-induced growth inhibitor 1 (OSGIN1)

  • 中文名称：
    人OSGIN1重组蛋白
  • 货号：
    CSB-YP891941HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OSGIN1重组蛋白
  • 货号：
    CSB-EP891941HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OSGIN1重组蛋白
  • 货号：
    CSB-EP891941HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OSGIN1重组蛋白
  • 货号：
    CSB-BP891941HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OSGIN1重组蛋白
  • 货号：
    CSB-MP891941HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OSGIN1
  • Uniprot No.：
  • 别名：
    OSGIN1; BDGI; OKL38; Oxidative stress-induced growth inhibitor 1; Bone marrow stromal cell-derived growth inhibitor; BMSC-derived growth inhibitor; Ovary; kidney and liver protein 38; huOKL38; Pregnancy-induced growth inhibitor OKL38
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-560
  • 氨基酸序列
    MGKWRPRGCC RGNMQCRQEV PATLTSSELF STRNQPQPQP QPLLADAPVP WAVASRMCLT PGQGCGHQGQ DEGPLPAPSP PPAMSSSRKD HLGASSSEPL PVIIVGNGPS GICLSYLLSG YTPYTKPDAI HPHPLLQRKL TEAPGVSILD QDLDYLSEGL EGRSQSPVAL LFDALLRPDT DFGGNMKSVL TWKHRKEHAI PHVVLGRNLP GGAWHSIEGS MVILSQGQWM GLPDLEVKDW MQKKRRGLRN SRATAGDIAH YYRDYVVKKG LGHNFVSGAV VTAVEWGTPD PSSCGAQDSS PLFQVSGFLT RNQAQQPFSL WARNVVLATG TFDSPARLGI PGEALPFIHH ELSALEAATR VGAVTPASDP VLIIGAGLSA ADAVLYARHY NIPVIHAFRR AVDDPGLVFN QLPKMLYPEY HKVHQMMREQ SILSPSPYEG YRSLPRHQLL CFKEDCQAVF QDLEGVEKVF GVSLVLVLIG SHPDLSFLPG AGADFAVDPD QPLSAKRNPI DVDPFTYQST RQEGLYAMGP LAGDNFVRFV QGGALAVASS LLRKETRKPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the differentiation and proliferation through the regulation of cell death.
  • 基因功能参考文献：
    1. The results support the concept that smoking-induced upregulation of OSGIN1 is one link between smoking-induced stress and enhanced-autophagy in the human airway epithelium. PMID: 28548877
    2. miR-320a has a role in modulating the induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells PMID: 24786516
    3. Identify OSGIN1 as a tumor suppressor that is down-regulated or altered in human hepatocellular carcinoma. PMID: 24417816
    4. Data suggest that OKL38 regulates mitochondria morphology and functions during apoptosis together with p53. PMID: 22912861
    5. Expression in cultured tumor cells resulted in growth inhibition and cell death. PMID: 14570898
    6. BDGI (Bone marrow stromal cell-derived growth inhibitor) inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis [BDGI] PMID: 15569677
    7. The 5'UTRs of OKL38 might play an important role in downregulation of its protein and the absence of OKL38 could lead to the development or progression of hepatocellular carcinoma. PMID: 16924236
    8. identify OKL38 as a novel p53 target gene that is regulated by Peptidylarginine deiminase 4 and plays a role in apoptosis PMID: 18499678

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  • 蛋白家族：
    OKL38 family
  • 组织特异性：
    Ubiquitous. Highest expression in the ovary, testis, kidney, skeletal muscle and liver. Weakly expressed in spleen, heart, kidney, and pancreas. Highly expressed in tumor cells (at protein level).
  • 数据库链接：

    HGNC: 30093

    OMIM: 607975

    KEGG: hsa:29948

    UniGene: Hs.128055