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  4. Recombinant Human Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS1)

Recombinant Human Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS1)

  • 货号：
    CSB-YP867127HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP867127HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP867127HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP867127HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP867127HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NUCKS1
  • Uniprot No.：
  • 别名：
    FLJ21480; FLJ32016; FLJ38536; JC7; NUCKS 1; NUCKS; NUCKS_HUMAN; Nucks1; Nuclear casein kinase and cyclin dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin dependent kinases substrate; Nuclear ubiquitous casein and cyclin-dependent kinases substrate; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate; P1; Potential LAG1 interactor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-243
  • 氨基酸序列
    MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS GKNSQEDSED SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA SKQREMLMED VGSEEEQEEE DEAPFQEKDS GSDEDFLMED DDDSDYGSSK KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKGKVG RPTASKASKE KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS GED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
  • 基因功能参考文献：
    1. our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of Parkinson's disease development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to Parkinson's disease and shows a male genetic distribution bias in the Han Chinese population. PMID: 29607885
    2. High NUCKS1 expression is associated with drug resistance in lung cancer. PMID: 26989074
    3. NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer PMID: 28877654
    4. NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC PMID: 26968889
    5. The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression. PMID: 26323318
    6. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators. PMID: 24931609
    7. NUCKS1 expression did not increase Tat nuclear localization. PMID: 25116364
    8. NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma PMID: 24819170
    9. NUCKS-1 overexpression is associated with obesity and with breast cancer. PMID: 24568505
    10. We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential. PMID: 25119009
    11. s suggest that NUCKS is involved in cellular responses following PDT. PMID: 24284105
    12. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis. PMID: 24140890
    13. Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer. PMID: 23065711
    14. The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression. PMID: 19664271
    15. Overexpression of NUCKS can play significant role in breast cancer biology. PMID: 20069058
    16. Two putative nuclear localization signals have been identified and characterized in NUCKS. PMID: 17604136
    17. NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described. PMID: 18491381

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.
  • 数据库链接：

    HGNC: 29923

    OMIM: 611912

    KEGG: hsa:64710

    STRING: 9606.ENSP00000356110

    UniGene: Hs.213061