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  4. Recombinant Human Nuclear factor 1 B-type (NFIB)

Recombinant Human Nuclear factor 1 B-type (NFIB)

  • 中文名称：
    人NFIB重组蛋白
  • 货号：
    CSB-YP015755HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NFIB重组蛋白
  • 货号：
    CSB-EP015755HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NFIB重组蛋白
  • 货号：
    CSB-EP015755HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NFIB重组蛋白
  • 货号：
    CSB-BP015755HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NFIB重组蛋白
  • 货号：
    CSB-MP015755HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NFIB
  • Uniprot No.：
  • 别名：
    CCAAT Box Binding Transcription Factor; CCAAT-box-binding transcription factor; CTF; HMGIC/NFIB; NF-I/B; NF1-B; NF1B; NF1B2; NFI-B; NFI-RED; Nfib; NFIB_HUMAN; NFIB2; NFIB3; Nuclear factor 1 B-type; Nuclear factor 1/B; Nuclear Factor 1B; Nuclear Factor I B; Nuclear factor I/B; TGGCA Binding Protein; TGGCA-binding protein; TRANSCRIPTION FACTOR NFIB
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-420
  • 氨基酸序列
    MYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQSWYLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能参考文献：
    1. High NF1B expression is associated with cell growth, aggressiveness, metastasis in gastric cancer. PMID: 30015981
    2. Studied role of miR-30d in tumor invasiveness and migration in non-small lung cancer (NSCLC). Found miR-30d suppressed cell migration and invasion by directly targeting nuclear factor I B (NFIB) in NSCLC. PMID: 28861760
    3. Study highlighted the paradoxical involvement of NFIB in both the inhibition and promotion of tumor development as well as progression in different malignancies; especially between different tumor subtypes within a single organ system, such as in lung, brain and skin,which corroborates its diverse and distinct roles in specific tissues and cell types. [review] PMID: 28596133
    4. we report that the transcription factor NFIB is associated with significantly improved survival in glioblastoma PMID: 27083054
    5. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. PMID: 27373156
    6. low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients PMID: 27357447
    7. Data indicate that NFIB protein increases EZH2 protein expression downstream of BRN2 protein, which further decreases MITF protein levels. PMID: 28119061
    8. In benign prostatic hyperplasia, luminal NFIB loss correlated with more severe disease. in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA1 binding sites. PMID: 26677878
    9. These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. PMID: 26084801
    10. Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR-365 in cutaneous squamous cell carcinoma development PMID: 24949940
    11. multivariate analysis co-overexpression of NFIB, RANK and RANKL significantly increased the risk of metastasis with an odds ratio of 13.59 PMID: 25764026
    12. Increased expression of NF1B is associated with pilocytic astrocytoma. PMID: 23161775
    13. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity. PMID: 22180456
    14. Tissue microarray results from invasive breast cancer patients, and the immunohistochemistry results showed a significant association between NFIB expression and nuclear grade, estrogen receptor, and HER2 expression status. PMID: 21925980
    15. study revealed that miRNA (miRs-372/373) can promote HBV expression through a pathway involving the transcription factor PMID: 21608007
    16. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation PMID: 21764851
    17. these results suggest that NFIB is a novel and specific biomarker for oxaliplatin resistance in human cancers PMID: 21087353
    18. The the MYB-NFIB fusion characterizes a subset of ACCs and contributes to MYB overexpression. PMID: 20702610
    19. expression of NFI-B2 impairs CD4 transcription on CDd4-positive primary T-lymphocytes and cell lines in HIV-1 infection PMID: 12639247
    20. C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in tumor cells PMID: 17511965
    21. the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas PMID: 18663748
    22. Knockdown of NFIB and NFIC expression using siRNA decreased and increased IGFBP5 expression, respectively. PMID: 18809517
    23. lipomas containing NFIB rearrangements may be related to peculiar clinicohistologic features, including large size, deep situation, infiltration of surrounding muscles, or precocious occurrence. PMID: 19837271

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 数据库链接：

    HGNC: 7785

    OMIM: 600728

    KEGG: hsa:4781

    STRING: 9606.ENSP00000370340

    UniGene: Hs.644095