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  4. Recombinant Human Neurogenin-1 (NEUROG1)

Recombinant Human Neurogenin-1 (NEUROG1)

  • 中文名称：
    人NEUROG1重组蛋白
  • 货号：
    CSB-YP821709HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NEUROG1重组蛋白
  • 货号：
    CSB-EP821709HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NEUROG1重组蛋白
  • 货号：
    CSB-EP821709HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NEUROG1重组蛋白
  • 货号：
    CSB-BP821709HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NEUROG1重组蛋白
  • 货号：
    CSB-MP821709HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AKA; Ath4c; bHLHa6; Class A basic helix-loop-helix protein 6; Helix loop helix protein mATH 4C; MATH4C; NeuroD3; Neurog 1; Neurog1; Neurogenic basic helix loop helix protein; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; Neurogenin1; Ngn; NGN-1; Ngn1; NGN1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-237
  • 氨基酸序列
    MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
  • 基因功能参考文献：
    1. mutation not found in group of children with sensorineural hearing loss PMID: 26634621
    2. Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media. PMID: 25403753
    3. We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder PMID: 23419067
    4. Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer. PMID: 23034738
    5. NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer. PMID: 21326223
    6. Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks. PMID: 19813087
    7. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. PMID: 20102160
    8. Overexpression of the full-length Ngn1 induced neurite outgrowth in F11 cells in the absence of cAMP PMID: 12526089
    9. These results, along with a priori evidence for the involvement of neurog1 in neurodevelopment, suggest that variants in neurog1 might have a small effect on susceptibility to schizophrenia. PMID: 17044100
    10. Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1. PMID: 18799289

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expression restricted to the embryonic nervous system.
  • 数据库链接：

    HGNC: 7764

    OMIM: 601726

    KEGG: hsa:4762

    STRING: 9606.ENSP00000317580

    UniGene: Hs.248149