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  4. Recombinant Human NT-3 growth factor receptor (NTRK3), partial

Recombinant Human NT-3 growth factor receptor (NTRK3), partial

  • 货号：
    CSB-YP621947HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP621947HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP621947HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP621947HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP621947HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion ; GP145 TrkC ; gp145(trkC) ; GP145-TrkC; GP145TrkC ; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor ; NT 3 growth factor receptor ; NT 3 growth factor receptor precursor ; NT 3 receptor; NT-3 growth factor receptor; Ntrk3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; Trk-C; TRKC; TrkC tyrosine kinase; Tyrosine kinase receptor C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
  • 基因功能参考文献：
    1. High TrkC mRNA expression appears to be frequent in the sonic hedgehog subgroup and seems not to have a major effect on therapy responsiveness in medulloblastoma patients. PMID: 28695340
    2. Data show that neurotrophin 3 receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC) cells, patients' tumor samples. PMID: 28455963
    3. LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR. PMID: 27351280
    4. Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 rearrangement and ETV6-NTRK3 gene fusion. PMID: 27282352
    5. The prevalence of ETV6-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population PMID: 29046324
    6. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion. PMID: 26884591
    7. 5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA/SDHx/RAS pathways, including two additional cases with FGFR1-TACC1 and ETV6-NTRK3 fusions, are reported. PMID: 27974047
    8. High expression of TrkC is associated with glioblastoma. PMID: 28402394
    9. Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer. PMID: 28746220
    10. we demonstrate the expression of the ETV6-NTRK3 fusion oncogene in a small subset of inflammatory myofibroblastic tumors PMID: 27259007
    11. ETV6-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly. PMID: 28125451
    12. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 gene fusion PMID: 27631515
    13. A subset of ALK-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism. PMID: 26647767
    14. TrkC-miR2 as a novel regulator of Wnt signaling, which might be a candidate oncogenic colorectal cancer biomarker. PMID: 28100780
    15. Pilot study usee targeted exome sequencing in an attempt to discover novel candidate genes related to Internet Gaming Disorder. Despite a relatively small sample, the targeted exome sequencing was feasible and valuable and revealed that rs2229910 of NTRK3 may be a protective SNP against Internet Gaming Disorder. PMID: 27826991
    16. Case Report: ETV6-NTRK3 translocation in primary cutaneous mammary analog secretory carcinoma. PMID: 27763904
    17. the ETV6-NTRK3 fusion might identify a subset of gastrointestinal stromal tumours with peculiar clinicopathological characteristics PMID: 26606880
    18. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID: 26216473
    19. SNPs in the NTRK3 gene, pain, physical activity, and fear of falling were directly associated with depressive symptoms in older adults. PMID: 26055783
    20. Molecular analysis of ETV6 gene rearranged mammary analogue secretory carcinoma of salivary glands tumors with lack of classical ETV6-NTRK3 fusion. PMID: 26492182
    21. Spectrum of secretory breast carcinoma with ETV6-NTRK3 gene fusion ranging from low-grade to high-grade histology, with occasional low hormonal receptor expression, simplex genomic profiles, and possible unfavorable course. PMID: 26291510
    22. The role of NTRK3 in in paranoid schizophrenia development in Russians. PMID: 26410934
    23. The overall percentage of NTRK3 gene methylation frequency with subsequent loss of mRNA expression was significantly higher in glioma compared with control samples. PMID: 24840578
    24. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. PMID: 25772499
    25. findings suggest a novel pathophysiological mechanism involving NTRK3 in the development of VSDs PMID: 25196463
    26. Report molecular genetic tests for ETV6-NTRK3 for differential diagnosis of mammary analogue secretory carcinoma of the salivary gland. PMID: 25456394
    27. ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis. PMID: 24327398
    28. NTRK3 genetic variants may influence white matter integrity in brain regions implicated in neuropsychiatric disorders. PMID: 23727532
    29. Results show that TrkC plays physiological role in the pathogenesis of leukemia and have important implications for understanding various hematological malignancies. PMID: 23832765
    30. Report ETV6-NTRK3 gene fusion in mammary analogue secretory carcinoma of salivary glands with high-grade transformation. PMID: 24145651
    31. our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms PMID: 23874207
    32. Genetic evidence shows that TrkC and TrkB activation in early cortical neurons depends on transactivation by epidermal growth factor receptor signaling. PMID: 23416450
    33. provide evidence that a mutation of TrkC detected in a sporadic cancer is a loss-of-proapoptotic function mutation PMID: 23341610
    34. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
    35. The significant expression of Trk isoforms among advanced neuroblastoma cases support their role as possible risk assessment tools alongside N-Myc amplification status. PMID: 21728718
    36. SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region. PMID: 22265740
    37. TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo. PMID: 21788388
    38. Low TRKC is associated with low vincristine and lomustine response in medulloblastoma. PMID: 21617231
    39. Mesenchymal stem cells modified by adenovirus carrying the TrkC gene are further promoted to differentiate into neuron-like cells with the potency of forming synapses by overexpressing the NT-3 gene in Schwann cells. PMID: 19680743
    40. We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. PMID: 21401966
    41. NT3 and its receptor may be involved in early folliculogenesis, particularly in the activation of primordial follicles. PMID: 21392742
    42. This study demonistrated that Intron 12 in NTRK3 is associated with bipolar disorder. PMID: 20554328
    43. Overexpression of TrkC is associated with breast tumor growth and metastasis. PMID: 20802235
    44. Findings suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
    45. Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes. PMID: 19893451
    46. Although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms. PMID: 11877382
    47. Expression of the ETV6-NTRK3 gene fusion is a primary event in human secretory breast carcinoma. PMID: 12450792
    48. ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID: 14668342
    49. While survival rates were higher for patients with high TrkC expression, these differences were not statistically significant. PMID: 15198123
    50. truncated trkC is prevalent in the human prefrontal cortex and that neurons and glia may be responsive to NT-3 throughout life PMID: 15932601

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  • 相关疾病：
    Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
  • 数据库链接：

    HGNC: 8033

    OMIM: 191316

    KEGG: hsa:4916

    STRING: 9606.ENSP00000354207

    UniGene: Hs.185701