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  4. Recombinant Human Microspherule protein 1 (MCRS1)

Recombinant Human Microspherule protein 1 (MCRS1)

  • 货号：
    CSB-YP013611HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013611HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013611HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013611HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013611HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MCRS1
  • Uniprot No.：
  • 别名：
    58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58; MSP58; p78
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-462
  • 氨基酸序列
    MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA LIRAEAAKIT PQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U).
  • 基因功能参考文献：
    1. Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis. PMID: 27263857
    2. MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells. PMID: 28448870
    3. MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. PMID: 27192185
    4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
    5. The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001). PMID: 26849376
    6. Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients. PMID: 27468560
    7. MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR-155-Rb1 pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer. PMID: 26467212
    8. MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58. PMID: 25981436
    9. BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features. PMID: 26300492
    10. MiR-129* down-regulation induced MCRS1 overexpression. PMID: 25373388
    11. High expression of MSP58 was also an independent unfavorable prognostic factor. PMID: 23996240
    12. MSP58 could suppress the transcription of hTERT promoter. PMID: 24361335
    13. MSP58 expression in hepatocellular carcinoma is closely related to the prognosis. PMID: 23519485
    14. Our results demonstrated MSP58 might serve as a novel prognostic marker for colorectal cancer PMID: 22773039
    15. MSP58 contributes to the tumorigenesis of neuroblastoma by promoting cell proliferation. PMID: 22975844
    16. RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.RACGAP1 and MCRS1 may be cancer-related genes in NSCLC. PMID: 23225332
    17. MSP58 depletion induced cell cycle arrest. PMID: 22994740
    18. Interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. PMID: 23069210
    19. Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties. PMID: 22563078
    20. MCRS2 plays a negative role in stress-induced ASK1 activation. PMID: 22609355
    21. MCRS1 is a RanGTP-regulated factor essential for non-centrosomal microtubule assembly. PMID: 22081094
    22. the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69 PMID: 21533551
    23. These data highlight the importance of MSP58 in glioma progression. PMID: 18798870
    24. role in the modulation of Daxx-dependent transcriptional repression PMID: 11948183
    25. Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription. PMID: 16186106
    26. A subset of the p78 proteins comprises a component of the centrosome; p78 is essential for cell viability. PMID: 16547491
    27. Escorts fragile X mental retardation protein-containing silent ribonucleoparticles (mRNP)from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation. PMID: 16571602
    28. DIPA can act as a repressor of gene transcription, an activity that appears to be enhanced by p78. PMID: 17014843
    29. modulation of Ndrg2 level influences the cell cycle process together with MSP58 PMID: 17109818
    30. MCRS2, a new Nrf1-interacting protein, has a repression effect on Nrf1-mediated transcriptional activation PMID: 19187526
    31. Overexpression of MSP58 is associated with colorectal cancer. PMID: 19549253

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 组织特异性：
    Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
  • 数据库链接：

    HGNC: 6960

    OMIM: 609504

    KEGG: hsa:10445

    STRING: 9606.ENSP00000349640

    UniGene: Hs.25313