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  4. Recombinant Human Metastasis suppressor protein 1 (MTSS1)

Recombinant Human Metastasis suppressor protein 1 (MTSS1)

  • 货号：
    CSB-YP015201HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015201HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015201HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015201HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015201HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MTSS1
  • Uniprot No.：
  • 别名：
    2310003N14Rik; BC024131; D130001D01Rik; DKFZp781P2223 ; FLJ44694; KIAA0429; metastasis suppressor 1; Metastasis suppressor protein 1; Metastasis suppressor YGL 1 ; Metastasis suppressor YGL-1; MGC37896; MIM; MIMA; MIMB; missing in metastasis; Missing in metastasis protein; mKIAA0429; MTSS 1; Mtss1; MTSS1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-250
  • 氨基酸序列
    MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQK VADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVAN QLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETE KQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSS EQVILDLKGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
  • 基因功能参考文献：
    1. MTSS1 is stabilized by the protein phosphatase activity of the tumor suppressor PTEN. Our data show that PTEN loss in PDAC cells results in both increased metastatic potential and decreased MTSS1 expression. Furthermore, we show that ectopic MTSS1 expression rescues this effect. PMID: 29175021
    2. These data suggested that miR-411 played as oncogene in the osteosarcoma partly by inhibiting the MTSS1 expression. . PMID: 29453719
    3. Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. PMID: 28159994
    4. Data identify MTSS1 as a new Akt2-regulated gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 in CRC cells. PMID: 28068324
    5. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1. PMID: 27181205
    6. Overexpression of MTSS1 in PDAC cell lines leads to a loss of migratory potential in vitro and an increase in overall survival in vivo. Data provide insight into an important role for MTSS1 in suppressing tumor cell invasion and migration driven by the tumor microenvironment. PMID: 28146435
    7. Overexpression of MTSS1 reduced BUCC cell proliferation, cell-cycle progression and colony formation, but had no influence on BUCC cell apoptosis. PMID: 28739745
    8. in contrast to MIM, which is a prototype of I-BAR proteins and does not contain an SH3 domain, IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38 PMID: 27693783
    9. MTSS1 suppressed H1299 cell migration and invasion, and its expression level can be used as a new independent factor for determining the prognosis of non-small cell lung cancer. PMID: 27634022
    10. MTSS1 is a new authentic target of miR-96 in prostate carcinoma. PMID: 27164937
    11. Down-regulation of MTSS1 expression is associated with lymph node metastasis in Pancreatic Cancer. PMID: 26198729
    12. Low expression of Mtss1 is associated with Chronic myeloid leukemia. PMID: 26621336
    13. MTSS1 plays an essential inhibitory role in the development and progression of ovarian cancers PMID: 26316204
    14. our findings suggest that MTSS1 might have a context-dependent function and could act as a tumor suppressor, which is pharmacologically targetable in AML patients. PMID: 25996952
    15. EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer. PMID: 25783158
    16. These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN and as a prognosis biomarker in Glioblastomas PMID: 25385572
    17. Data shows that MTSS1 is highly expressed in non-small-cell lung carcinomas compared with non-neoplastic lung tissues and may serve as an independent prognostic factor. PMID: 25625275
    18. The absence of MIM led to PTPdelta-mediated activation of SRC. PMID: 25287652
    19. MTSS1 expression was analyzed in normal and cancerous tissue specimens from Chinese patients with Hilar cholangiocarcinoma. PMID: 23852458
    20. MTSS1 is a metastasis driver in a subset of human melanomas. PMID: 24632752
    21. In breast tumor samples, miR-182 induction is linked to downregulation of MIM, RhoA activation and poor prognosis. PMID: 23474751
    22. Compared with normal tissue, miR-182 was up-reg'd and MTSS1 was down-reg'd in HCC tissues. Over-expression of miR-182 was correlated with intrahepatic metastasis. There was a negative correlation between miR-182 and MTSS1 expression in both HCC tissues. PMID: 22681717
    23. Data show that the expression of the metastasis suppressor 1 (MTSS1) gene was regulated by miR-135a overexpression and knockdown. PMID: 23017832
    24. Loww MTSS1 expression is associated with kidney cancer. PMID: 23350348
    25. MiR-23a expression promotes colon carcinoma cell growth, invasion and metastasis through inhibition of the MTSS1 gene. PMID: 22455847
    26. the dimeric configuration is essential for MIM-mediated membrane remodelling and serves as a proper target to develop antagonists specifically against an I-BAR-domain-containing protein. PMID: 22721729
    27. MTSS1 was characterized as a novel tumor suppressor gene in hepatocellular carcinoma PMID: 21909138
    28. Data show that Mtss1 drives enhanced junction formation specifically by elevating Rac-GTP. PMID: 22479308
    29. at high cell densities, Mtss1 impacts negatively on EGF signaling and this suggests why it inhibits metastasis. PMID: 21927027
    30. Anthrax edema toxin induced transendothelial cell tunnels are resealed by MIM via Arp2/3-driven actin polymerization. PMID: 22100162
    31. MTSS1 is expressed at low levels or is absent from human bladder cancer cells. PMID: 21965727
    32. MTSS1 serves as a potential prognostic indicator in human oesophageal squamous cell carcinoma and may be an important target for cancer therapy. PMID: 21696600
    33. the current knowledge of MTSS1's role in cancer metastasis, carcinogenesis, and development is discussed. PMID: 21196400
    34. Downregulation of metastasis suppressor 1 is associated with nodal metastasis and gastric cancer. PMID: 20712855
    35. a potential metastasis suppressor gene in bladder cancer; data suggest that it may be involved in cytoskeletal organization PMID: 12082544
    36. missing in metastasis protein and insulin receptor tyrosine kinase substrate p53 have a conserved novel actin bundling/filopodium-forming domain PMID: 14752106
    37. Our data indicate that down-regulation of MIM and/or MIM-B expression can occur in bladder cancer cell lines but is not associated with increased invasive behaviour. PMID: 15488640
    38. MIM-B is unlikely to be a metastasis suppressor but acts as a scaffold protein that interacts with Rac, actin and actin-associated proteins to modulate lamellipodia formation. PMID: 16280553
    39. The expression of metastasis suppressor MIM is regulated by DNA methylation of a CpG island within its promoter region. PMID: 16921485
    40. Elevated MIM-B expression may influence the development of hepatocellular carcinoma and may possibly be a powerful indicator for the disease at an early stage. PMID: 17442377
    41. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. PMID: 19328678
    42. MTSS1, also known as MIM, is a modular hedgehog inducible protein that contains a dimerization domain and a distinct activation/scaffolding domain that binds RPTPdelta and induces membrane projections. PMID: 15684034
    43. MTSS1, also known as MIM, is a hedgehog inducible protein expressed in carcinomas that potentiates Gli transcription factor activity PMID: 15545630

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MTSS1 family
  • 组织特异性：
    Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
  • 数据库链接：

    HGNC: 20443

    OMIM: 608486

    KEGG: hsa:9788

    STRING: 9606.ENSP00000429064

    UniGene: Hs.336994