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  4. Recombinant Human Matrix metalloproteinase-21 (MMP21)

Recombinant Human Matrix metalloproteinase-21 (MMP21)

  • 货号：
    CSB-YP854014HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP854014HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP854014HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP854014HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP854014HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MMP21
  • Uniprot No.：
  • 别名：
    MMP21Matrix metalloproteinase-21; MMP-21; EC 3.4.24.-
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    145-569
  • 氨基酸序列
    SPRAPL SLSRRGWQPR GYPDGGAAQA FSKRTLSWRL LGEALSSQLS VADQRRIVAL AFRMWSEVTP LDFREDLAAP GAAVDIKLGF GRGRHLGCPR AFDGSGQEFA HAWRLGDIHF DDDEHFTPPT SDTGISLLKV AVHEIGHVLG LPHTYRTGSI MQPNYIPQEP AFELDWSDRK AIQKLYGSCE GSFDTAFDWI RKERNQYGEV MVRFSTYFFR NSWYWLYENR NNRTRYGDPI QILTGWPGIP THNIDAFVHI WTWKRDERYF FQGNQYWRYD SDKDQALTED EQGKSYPKLI SEGFPGIPSP LDTAFYDRRQ KLIYFFKESL VFAFDVNRNR VLNSYPKRIT EVFPAVIPQN HPFRNIDSAY YSYAYNSIFF FKGNAYWKVV NDKDKQQNSW LPANGLFPKK FISEKWFDVC DVHISTLNM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
  • 基因功能参考文献：
    1. MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
    2. loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
    3. Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
    4. Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
    5. These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
    6. analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
    7. MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
    8. MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
    9. MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
    10. The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
    11. MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
    12. MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
    13. A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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  • 相关疾病：
    Heterotaxy, visceral, 7, autosomal (HTX7)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
  • 数据库链接：

    HGNC: 14357

    OMIM: 608416

    KEGG: hsa:118856

    STRING: 9606.ENSP00000357798

    UniGene: Hs.314141