Recombinant Human Macrophage metalloelastase (MMP12)

1. Studied association of matrix metallopeptidase 12 (MMP12) -82 A>G promoter single nucleotide polymorphism (SNP) with bronchial asthma in a Bulgarian population. Results suggest the variant G allele of the MMP12 -82 A>G promoter polymorphism might considered protective for development of bronchial asthma. PMID: 29390099
2. that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma PMID: 29033183
3. MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity. PMID: 29317790
4. Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis] PMID: 29906531
5. The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha. These findings suggest MMP12 involved in trophoblast invasion during the first trimester. PMID: 28990117
6. In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling. PMID: 27807143
7. The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease PMID: 28655442
8. M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques. PMID: 28343758
9. MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R surface levels. MMP12 production by these cells was induced by CSF2, and treatment with a CD200R ligand reduced CSF2-induced MMP12 production. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression. PMID: 29101312
10. G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population PMID: 28692348
11. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1. PMID: 28385529
12. To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 and MMP-13 expression, which is further controlled by NF-kappaB signaling. PMID: 27377745
13. This study demonstrated that the MMP-12 levels was significantly higher in patients with atheromatous plaques than in those without plaques. PMID: 27345464
14. High MMP12 expression is associated with gastric cancer. PMID: 28098914
15. Study evaluated MMP-12 and TIMP-1, TIMP-2, TIMP-3, and TIMP-4 levels in 40 patients with asymptomatic and symptomatic critical carotid artery stenosis (CAS) with neurologic symptoms onset within the preceding 12 hours; results suggest that MMP-12 is related to critical CAS independently on symptoms, moreover, TIMP-3 and TIMP-4 seem to be specifically related to stroke PMID: 27746079
16. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans. PMID: 26608672
17. Productive complex between MMP-12 and synthetic triple-helical collagen V, are revealed through paramagnetic NMR. PMID: 26887942
18. These results proved that MMP-12 expression was increased in cutaneous melanoma and associated with tumor progression. It also provided the first evidence that MMP-12 level could be an independent prognostic marker for patients with cutaneous melanoma PMID: 26040769
19. fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12. PMID: 25435370
20. AG and GG genotypes of the MMP12 rs2276109 variant were significantly under-represented among patients with non-contact anterior cruciate ligament rupture compared to controls. PMID: 21410539
21. HnRNP K can induce MMP12 expression and enzyme activity through activating MMP12 promoter, which promotes cell migration and invasion in nasopharyngeal carcinoma cells. PMID: 24885469
22. We identified a novel association with an MMP12 locus in large artery atherosclerosis (rs660599; p = 2.5x10), with independent replication in a second population PMID: 25078452
23. Thrombin-activated microglia expression of tumor necrosis factor-a, interleukin-1b and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms when the HAESCs were co-cultured with microglia cells PMID: 24424266
24. Macrophage MMP12 regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. PMID: 24914938
25. MMP12 is located in genes previously associated with chronic obstructive pulmonary disease susceptibility. PMID: 25006744
26. In acute aortic dissection patients, macrophage activation is strongly related to the clinical outcome of atherosclerotic disease and the role of MMP-12 as a specific marker. PMID: 24432723
27. In emphysema, MMP12 mRNA expression was inversely related to the diffusing capacity of the lung. PMID: 23900981
28. These findings suggest that inhibiting extracellular MMP-12 could be a new avenue for the development of antiviral treatments PMID: 24784232
29. role of matrix metalloproteinase 12 in non-small cell lung cancer PMID: 24398311
30. MMP-12 proteolytic activity exists within the aorta specimens and blood samples from aortic dissection patients. PMID: 23642232
31. The present study evaluated the association between these single nucleotide polymorphisms in MMP12 and MMp13 in patients with colorectal cancer (CRC) patients and healthy controls. PMID: 23898086
32. MMP-12 expression was found to be significantly associated with extracapsular spread and correlated with nodal metastasis in head and neck squamous cell carcinoma. No relation was found between MMP expression and survival. PMID: 22907031
33. the endogenous matrix metalloprotease-12 active form can be detected with a novel broad spectrum activity-based probe PMID: 23271741
34. confers susceptibility to asthma and is associated with asthma severity in a Japanese population PMID: 23075521
35. Suggest that the inter-individual variability in the MMP-12 gene variation may not be a risk factor for vulnerable plaques in the Chinese Han population. PMID: 22863605
36. Studied the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A. A 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment was used to monitor and distinguish protein amide protons in fast exchange with bulk water. PMID: 22528292
37. Our results establish microglia as a significant source of progranulin(PGRN), and MMP-12 as modulators of PGRN PMID: 22509390
38. analysis of orally potent and selective small molecule inhibitor of MMP-12 for treatment of COPD and asthma in human and mouse models PMID: 22153340
39. Sputum MMP-12 concentrations and activity in patients with chronic obstructive pulmonary disease are associated with the extent of emphysema PMID: 22305682
40. MMP-12 participates in experimental small airway modelling and in emphysema [review] PMID: 21920892
41. Provide in vivo evidence of an effect of MMP12 on fibrinogen level. PMID: 22119538
42. Surfaces of MMP-12 far from its active site have been found to affect degradation and affinity for elastin substrates; main exosite 1 has been extended to Asp-124 that binds calcium while exosite 2 comprises residues near the back of the catalytic domain. PMID: 21967233
43. rs652438 SNP alters MMP-12 activity with the A allele being more active, which is associated with increased macrophage infiltration and emphysema in the lungs of patients with COPD. These findings further implicate MMP-12 and this SNP in COPD PMID: 21730350
44. MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of hepatocellular patients after liver resection. PMID: 21683576
45. High expression of MMP-12 in squamous laryngeal carcinoma was related to significant hyperplasia. PMID: 17357518
46. Data suggest that the matrix metalloproteinase-12 rs2276109 gene polymorphism may contribute to susceptibility to systemic sclerosis (SSc), and in particular to diffuse cutaneous SSc and pulmonary fibrosis. PMID: 20595276
47. Overexpression of human macrophage metalloelastase is strongly correlated with the reduced angiogenesis and vascular invasion of gastric carcinoma, and may serve as a useful predictive indicator in patients with this disease. PMID: 20127415
48. distribution of N357S genotypes not significantly different in chronic obstructive pulmonary disease PMID: 20160424
49. Individuals with MMP-12 -82A/G and MMP-13 -77A/A might have higher risk of overall or special histological type of epithelial ovarian carcinoma development. PMID: 20376807
50. The catalytic domain of MMP-12 binds to the triple helix and cleaves the typical sites -Gly(775)-Leu(776)- in alpha-2 type I collagen and -Gly(775)-Ile(776)- in alpha-1 type I and type III collagens and at multiple other sites in both collagen types. PMID: 19932771

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HGNC: 7158

OMIM: 601046

KEGG: hsa:4321

UniGene: Hs.1695