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  4. Recombinant Human Krueppel-like factor 9 (KLF9)

Recombinant Human Krueppel-like factor 9 (KLF9)

  • 货号：
    CSB-YP622687HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP622687HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP622687HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP622687HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP622687HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KLF9
  • Uniprot No.：
  • 别名：
    Basic transcription element binding protein 1; Basic transcription element-binding protein 1; BTE binding protein 1; BTE-binding protein 1; BTEB 1; BTEB; BTEB1; GC box binding protein 1; GC-box-binding protein 1; KLF 9; KLF9; KLF9_HUMAN; Krueppel like factor 9 ; Krueppel-like factor 9; Transcription factor BTEB 1; Transcription factor BTEB1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-244
  • 氨基酸序列
    MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT TESGSSPSHS PEERQDPGSA PSPLSLLHPG VAAKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL ANAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.
  • 基因功能参考文献：
    1. results demonstrated the molecular interaction between miR-378 and KLF9, indicating the therapeutic potential of miR-378 for osteosarcoma. PMID: 29490146
    2. KLF9 suppressed tumorigenicity of the pancreatic ductal adenocarcinoma by negatively regulating frizzled-5. PMID: 29621541
    3. KLF9 could down-regulate MMP9 expression to inhibit breast cancer metastasis. PMID: 29107105
    4. KLF9 status was associated with differentiation and vascular invasion expression and was found to be a valuable prognostic factor for patients with pancreatic ductal adenocarcinoma PMID: 28668877
    5. In conclusion, LPA plays dual roles as a ligand mediator through the activation of cell surface G-coupled protein receptors and as an intracellular second messenger through the activation of PPARgamma. We discuss the contribution of the LPA1-PPARgamma-KLF9 axis to neurite outgrowth and proliferation in human iPSC-derived neurons. PMID: 28716732
    6. miR-141-3p/KLF9 may play an important role in regulating the growth of prostate cancer PMID: 27956179
    7. The expression of KLF9 is down-regulated in esophageal squamous cell carcinoma and inversely correlated with the clinical features. PMID: 25641762
    8. Suggest role for miR-570/KLF9 molecular network in controlling lung carcinoma progression. PMID: 26045791
    9. TRs cooperate with KLF9 to regulate hepatocyte proliferation and differentiation and early stages of organogenesis and that TRs exert widespread and important influences on ESC biology. PMID: 25330987
    10. Myometrial KLF9 may contribute to the onset of human parturition through its regulation of PGR expression and inflammatory signaling networks. PMID: 25313913
    11. the expression of KLF9 is up-regulated in human ovarian cancer; KLF9 knockdown significantly inhibited cell proliferation and resulted in cell cycle arrest in the G0/G1 phase PMID: 25216959
    12. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation PMID: 25652467
    13. Palmitic acid increases Ppargamma and Klf6 & Klf9 gene expression and promotes triglyceride accumulation in HepG2 cells. PMID: 25686501
    14. Reduced KLF9 expression is associated with glioma. PMID: 25305446
    15. Data indicate that integrin alpha6 repression by Kruppel-like factor-9 (KLF9) inhibits glioblastoma cell stemness and tumorigenicity. PMID: 25288800
    16. increased KLF9 expression is in part responsible for CYP2D6 induction during pregnancy via the potentiation of HNF4alpha transactivation of CYP2D6. PMID: 25217496
    17. KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression by increasing protein stability. PMID: 25242357
    18. We confirmed that PDCD5 overexpression stimulated the promoter activities of KLF9 by luciferase reporter assays. PMID: 24173774
    19. Data collectively show that KLF9 substantially inhibits AKT activation and abrogates tumor growth of PCa cells. PMID: 24737412
    20. Nrf2 amplifies oxidative stress via induction of Klf9. PMID: 24613345
    21. Studied mRNA levels of FOXO1, KLF9 and YT521 in human normal and cancerous endometrial tissue. In subjects with endometrial cancer the KLF9 mRNA level (1.12 +/- 0.38) was lower (p < 0.001) when compared to controls (3.11 +/- 1.52). PMID: 23865345
    22. Klf9 affects keratinocyte proliferation/differentiation by controlling the expression of target genes in a daytime-dependent manner. PMID: 22711835
    23. It was suggested that KLF9 loss-of-expression accompanying endometrial carcinogenesis may predispose endometrial epithelial cells to mechanisms of escape from estrogen-mediated growth regulation, leading to progression of established neoplasms. PMID: 21543766
    24. Loss of KLF9 coregulation of endometrial stromal progesterone receptor-responsive gene networks may underlie progesterone resistance in endometriosis. PMID: 22259059
    25. Data identify KLF9 as a novel and potentially clinically relevant transcriptional regulator of drug-induced apoptosis in multiple myeloma cells. PMID: 22144178
    26. Expression levels of HOXA11, LIF and BTEB1 mRNA were measured in endometrium during the mid-secretory phase using semi-quantitative RT-PCR PMID: 21987111
    27. these results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells. PMID: 21280156
    28. homeobox A10(HOXA10) directly and selectively repressed Kruppel-like factor 9 expression in endometrial epithelial cells PMID: 20463357
    29. BTEB1/Progesterone receptor cross-talk to facilitate progesterone dependent gene transcription in endometrial epithelial cells. PMID: 16384861
    30. identify KLF9 as a transcriptional repressor of estrogen receptor alpha signaling PMID: 17717078
    31. Transient transfection of Kruppel-like factor 9 suppressed LDLR, steroidogenic acute regulatory protein, and CYP11A PMID: 18056793
    32. KLF9 did not reveal a otosclerosis-causing mutation PMID: 18224337
    33. HNF4alpha regulates thyroid hormone homeostasis through transcriptional regulation of the Dio1 gene with GATA4 and KLF9 PMID: 18426912
    34. KLF9 may be involved in the carcinogenesis of human colorectal cancer. PMID: 18477211
    35. KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and which may underlie altered tumor biology with aberrant KLF9 expression. PMID: 18783612
    36. T3-induced genes identified basic transcription element binding protein 1/Kruppel-like factor 9 (BTEB1/KLF9) and GAR22 as TR target genes PMID: 19375645

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Epidermis (at protein level).
  • 数据库链接：

    HGNC: 1123

    OMIM: 602902

    KEGG: hsa:687

    STRING: 9606.ENSP00000366330

    UniGene: Hs.150557