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  4. Recombinant Human Krueppel-like factor 2 (KLF2)

Recombinant Human Krueppel-like factor 2 (KLF2)

  • 货号：
    CSB-YP896743HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP896743HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP896743HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP896743HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP896743HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    KLF 2; Klf2; KLF2_HUMAN; Krueppel-like factor 2; Kruppel like factor 2; Kruppel like factor; Kruppel like factor LKLF; Kruppel-like factor 2 (lung); Lklf; Lung krueppel like factor; Lung krueppel-like factor; Lung Kruppel like zinc finger transcription factor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-355
  • 氨基酸序列
    MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
  • 基因功能参考文献：
    1. Overall, the present work showed that MIF is a shear stress-sensitive cytokine and is transcriptionally regulated by KLF2, suggesting that laminar shear stress exerts its athero-protective effect in part by directly inhibiting pro-inflammatory MIF expression. PMID: 29403061
    2. results confirm the association of the KLF2 and NOTCH2-mutations with shorter median treatment-free survival and suggest the possible usefulness of the identification of these changes for the diagnosis of splenic marginal zone lymphoma. PMID: 28522570
    3. LPS exposure resulted in hypermethylation in KLF2 promoter in HUVECs, which subsequently led to downregulation of the KLF2 expression. PMID: 28578476
    4. The expression of SH3PXD2A-AS1 was inversely correlated with the expression of P57 and KLF2 in Colorectal Cancer tissue samples. PMID: 29734178
    5. Suppression of miR-150 led to up-regulation of KLF2, which in turn protected ATDC5 cells against IL-1-induced injury. PMID: 29996115
    6. Suberanilohydroxamic acid has KLF2-dependent anti-inflammatory effects, repressing vascular inflammation and atherosclerosis. PMID: 29191808
    7. we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-kappaB. PMID: 29125549
    8. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
    9. Studies indicate that the physiological changes in miR-200b levels during acute hypoxia may actually have a proangiogenic effect through Klf2 downregulation and subsequent stabilization of HIF-1 signaling. PMID: 29042072
    10. The flow-mediated miR-10a expression is regulated by Kruppel-like factor 2 through modulation in RARalpha-RARE binding, with the consequent regulation in GATA6/VCAM-1 in endothelial cells. PMID: 28167758
    11. the effects of omentin-1 on KLF2 expression are mediated by p53. PMID: 29408455
    12. ZFAS1 over-expression confers an oncogenic function in gastric cancer and this function is partly dependent on repressing KLF2 and NKD2 PMID: 27246976
    13. These results indicated that KLF2 plays an important role in colorectal cancer PMID: 28628187
    14. miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in type 1 diabetes mellitus islet autoimmunity. PMID: 27791035
    15. s found that there was negative correlation between LINC01133 and KLF2, P21 or E-cadherin in NSCLC. PMID: 26840083
    16. s found that knockdown of ANRIL expression could impair cell proliferation and invasion and induce cell apoptosis both in vitro and in vivo. s also found that ANRIL could epigenetically repress KLF2 transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. PMID: 27391317
    17. overexpression of Kruppel-like factor 2 ameliorated the degradation of type collagen while silencing of Kruppel-like factor 2 exacerbated the degradation of type collagen induced by interleukine-1beta. PMID: 28873368
    18. KLF2 and KLF4 serve as important regulators that promote hemoglobin alpha expression in the endothelium. PMID: 28825355
    19. Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells. PMID: 27195672
    20. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis. PMID: 27855271
    21. The findings point to KLF2 as a new gene involved in heritable pulmonary arterial hypertension. PMID: 28188237
    22. we provide evidence that the tumor-suppressive microRNA miR-1825 controls KLF2 expression. Reporter gene analyses revealed that both microRNAs directly targeted the 3'-untranslated region of KLF2 messenger RNA. These data demonstrated that miR-1825 expression in serum of human glioma was associated with tumorigenesis and miR-1825 may be used as a biomarker for identification of the pathological grade of glioma. PMID: 28475008
    23. Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. PMID: 27501756
    24. lysine-specific demethylase-1 is an important oncogene in gastric cancer, and lysine-specific demethylase-1-mediated epigenetic repression of KLF2 plays a critical role in gastric cancer development and progression. PMID: 28381185
    25. KLF2 is shown to be downregulated in pancreatic ductal adenocarcinoma (PDAC) clinical samples and overexpression of KLF2 inhibits the growth, migration, and metastasis of PDAC cancer cells. PMID: 26449825
    26. KLF2 expression was decreased in gastric cancer and negatively correlated with lymphatic metastasis. KLF2 overexpression inhibited cell proliferation and invasive potential and downregulated the protein expression of PCNA, Bcl-2 and MMP-9 in GC cells. KLF2 overexpression reduced xenograft tumor growth. PMID: 27655487
    27. our data highlight an important role for KLF2/c-myc pathway in HCC development and progression. PMID: 26853883
    28. s show that KLF2 induces the expression of CRABP2 and RARgamma and inhibits the expression FABP5 and PPARbeta/delta thereby shifting RA signaling from the pro-carcinogenic FABP5/PPARbeta/delta to the growth-suppressing CRABP2/RAR path. PMID: 26416422
    29. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of Ang2. PMID: 26456066
    30. In hyperuricemia, miR-92a downregulation increased KLF2 expression, subsequently inhibiting VEGFA, which resulted in decreased angiogenesis. PMID: 26299712
    31. These data provide support for a continuous role of KLF2 in stabilizing the vessel wall via co-temporal expression of eNOS and AQP1 both preceding and during the pathogenesis of atherosclerosis. PMID: 26717516
    32. These results indicate that the KDM3A-KLF2-IRF4 pathway plays an essential role in multiple myeloma cell survival and homing to the bone marrow, and therefore represents a therapeutic target. PMID: 26728187
    33. Expression of KLF4 in mononuclear leukocytes positively correlates with cellular markers of immune activation, whereas KLF2 expression negatively correlates with markers of subclinical atherosclerosis in this HIV-infected population. PMID: 26372274
    34. TUG1 overexpression was induced by nuclear transcription factor SP1 and TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. PMID: 26336870
    35. studies identify gain of MEKK3 signalling and KLF2/4 function as causal mechanisms for cerebral cavernous malformations pathogenesis that may be targeted to develop new CCM therapeutics PMID: 27027284
    36. In conclusion, KLF2 suppressed the angiogenesis of LSECs through inhibition of cell proliferation, migration, and vessel tube formation. PMID: 26212440
    37. TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression PMID: 25728677
    38. We showed that ANRIL may regulate the proliferation ability of HCC cells partially through silencing of KLF2 PMID: 25966845
    39. Here we report that HIV-1 down-modulates CD62L in productively infected naive and memory resting CD4 T cells while suppressing Foxo1 activity and the expression of KLF2 mRNA. PMID: 25330112
    40. Data suggest that KLF2 is involved in regulation of gene expression in vascular endothelium by dietary factors (here, effects of flavonoids on gene expression in cultured umbilical vein endothelial cells). PMID: 25542418
    41. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression PMID: 25672609
    42. Results show that lncRNA ANRIL plays a key role in non-small cell lung cancer (NSCLC) development by associating its expression with survival in patients with NSCLC through silencing of KLF2 and P21 transcription. PMID: 25504755
    43. Provide first evidence for existence of a previously unknown Erk5/KLF2/PAK1 axis, which may limit undesired cell migration in unperturbed endothelium and lower its sensitivity for migratory cues that promote vascular diseases including atherosclerosis. PMID: 25388666
    44. KLF2 mutation is the most common genetic change in splenic marginal zone lymphoma PMID: 25428260
    45. Our findings present that decreased KLF2 could be identified as a poor prognostic biomarker in NSCLC and regulate cell proliferation and apoptosis PMID: 25501704
    46. IKKbeta regulates endothelial thrombomodulin in a Klf2-dependent manner PMID: 25039491
    47. results suggest that KLF2 is involved in strict repression of hTERT expression through binding to the promoter in primary human T cells PMID: 25694435
    48. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. PMID: 25646266
    49. KLF2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma PMID: 25283840
    50. Shear stress-mediated repression of endothelial cell metabolism via KLF2 and PFKFB3 controls endothelial cell phenotype. PMID: 25359860

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 6347

    OMIM: 602016

    KEGG: hsa:10365

    STRING: 9606.ENSP00000248071

    UniGene: Hs.685136