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  4. Recombinant Human Krueppel-like factor 15 (KLF15)

Recombinant Human Krueppel-like factor 15 (KLF15)

  • 货号：
    CSB-YP883433HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP883433HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP883433HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP883433HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP883433HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KLF15
  • Uniprot No.：
  • 别名：
    Kidney enriched Kruppel like factor; Kidney-enriched krueppel-like factor; KKLF; KKLF protein; KLF 15; KLF15; KLF15_HUMAN; Krueppel-like factor 15; Kruppel like factor 15
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-416
  • 氨基酸序列
    MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4. Involved in podocyte differentiation. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
  • 基因功能参考文献：
    1. KLF15 over expression suppressed lung adenocarcinma cell growth, which was partly mediated by up-regulation of CDKN1A/p21 and CDKN2A/p15 expression. PMID: 29990857
    2. low expression of KLF15 was associated with chronic podocyte injury. PMID: 29901095
    3. the results of the present study suggested that overexpression of KLF15 in Eahy926 cells exhibited a protective effect against TNFalpha induced dysfunction via activation of Nrf2 signaling and inhibition of nuclear factor kappaB signaling. PMID: 29956764
    4. This review provides a summary of the experimental and human studies that have investigated the role of KLF15 in the development of cardiac hypertrophy. [review] PMID: 29702551
    5. analysis of the role of KLF15 in type 2 diabetes patients with left ventricle hypertrophy (LVH) has really advanced the importance of KLF15 in the physiology and pathophysiology of cardiac conditions, and also promoted us to understand the mechanism of type 2 diabetes-induced LVH. All these will lay a theoretical foundation for the potentially clinical prevention and treatment of LVH. PMID: 28499925
    6. The KLF15 SNP rs9838915 A allele was associated in a dominant manner with Left ventricular mass before and after adjustment for age, gender, body mass index and hypertension, and with adjusted septal and posterior wall thickness. PMID: 28400202
    7. KLF15 activates SOX9 expression directly. SOX9 is involved in KLF15 function during chondrogenic differentiation. PMID: 28923246
    8. study identifies novel genes associated with insulin sensitivity in adipocytes in women independently of obesity. KFL15 and SLC25A10 are inhibitors of insulin-stimulated lipogenesis under conditions when glucose transport is the rate limiting step PMID: 28570579
    9. In general, our study revealed that KLF15 is dramatically down-regulated in GC tissues and cell lines and that KLF15 is negatively associated with aggressive clinical characteristics, such as tumor stage, lymph node metastasis, and DFS. Importantly, up-regulation of KLF15 inhibits cell proliferation by regulating CDKN1A/p21 and CDKN1C/p57. PMID: 28421457
    10. KLF15 is directly induced by glucocorticoids in primary human airway smooth muscle and it represses ASM hypertrophy. PMID: 28375666
    11. the expression of KLF15 increased in the RA-treated cells regardless of fluidic condition PMID: 28320523
    12. In breast cancer cells, KLF6 and KLF15 are suppressed via miR-4262. PMID: 27629257
    13. Findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population. PMID: 27199507
    14. Case Reports: 2 girls with primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 fusion. PMID: 26523541
    15. Our results indicate that nuclear KLF15 expression suppresses breast cancer cell proliferation at least partially through p21 up-regulation and subsequent cell cycle arrest PMID: 25869021
    16. KLF15 as a key regulator of myocardial lipid utilization and is the first to implicate the KLF transcription factor family in cardiac metabolism. PMID: 24407292
    17. A previously unrecognized KLF15-dependent pathway regulates vascular smooth muscle cell proinflammatory activation. PMID: 23999430
    18. a critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury. PMID: 22493483
    19. Elucidation of this heretofore unrecognized role for KLF15 now implicates this factor as a central component of the transcriptional circuitry that coordinates physiologic flux of all three basic cellular nutrients: glucose, amino acids, and lipids PMID: 22493257
    20. Nitrogen homeostasis exhibits circadian rhythmicity, and is orchestrated by Kruppel-like factor 15. PMID: 22405069
    21. serves as a molecular link between myogenic factors and the activity of the D4Z4 enhancer, and it thus contributes to the overexpression of the DUX4c and FRG2 genes during normal myogenic differentiation and in FSHD. PMID: 21937448
    22. the GR target, Klf15, has a role in modulating airway function PMID: 21257922
    23. Kruppel-like factor 15 activates hepatitis B virus gene expression and replication. PMID: 21503941
    24. Glucocorticoid receptors promote adipogenesis via KLF15 gene expression as a transcriptional direct target. PMID: 20956975
    25. KLF11, but not KLF15, was essential for UCP1 expression during brown adipocyte differentiation of muBM3.1. PMID: 20709022
    26. Deficiency of the transcriptional regulator Kruppel-like factor 15 (Klf15) in mice leads to both heart failure and aortic aneurysm and Klf15 concentrations are markedly reduced in failing human hearts and in human aortic aneurysm tissues. PMID: 20375365
    27. Both Kruppel-like factor 15 and specificity protein 1 binding motifs are essential for human LRP5 promoter activity. PMID: 20141633
    28. KLF15 binds to multiple 9 bp consensus sites in the Rhodospin and IRBP promoters including the CRS-1 and G-rich repressor elements. An in vivo role for KLF15 in repressing photoreceptor-specific gene expression in the inner retina is hypothesized. PMID: 15963234
    29. These studies identify KLF15 as part of a heretofore unrecognized pathway regulating the cardiac response to hemodynamic stress PMID: 17438289
    30. KLF15 is a negative regulator of connective tissue growth factor expression and cardiac fibrosis. PMID: 18586263
    31. KLF15 is potentially a novel link between the regulation of testosterone production and fat stores by insulin in humans. PMID: 19366843

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  • 相关疾病：
    KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365).
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow o
  • 数据库链接：

    HGNC: 14536

    OMIM: 606465

    KEGG: hsa:28999

    STRING: 9606.ENSP00000296233

    UniGene: Hs.272215