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  4. Recombinant Human Junctional adhesion molecule C (JAM3), partial

Recombinant Human Junctional adhesion molecule C (JAM3), partial

  • 货号：
    CSB-YP874828HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP874828HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP874828HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP874828HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP874828HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FLJ14529; JAM 2 ; JAM 3; JAM C; JAM-2; JAM-3; JAM-C; JAM2 ; Jam3; JAM3_HUMAN; JAMC; Junctional adhesion molecule 3; Junctional adhesion molecule 3 precursor; Junctional adhesion molecule C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion.; Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
  • 基因功能参考文献：
    1. JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress. PMID: 28203682
    2. JAM-C controls Src family kinase (SFK) activation in leukemic stem cells and leukemia-initiating cell activity with exacerbated SFK activation was uniquely found within the JAM-C-expressing leukemic stem cell compartment. PMID: 28972073
    3. The role of JAM-C in the engraftment of human lymphoma B cells in mice was investigated. The binding of anti-JAM-C antibodies inhibited the phosphorylation of ERK1/2, without affecting other signaling pathways, identifying for the first time the intracellular MAPK cascade as the JAM-C-driven signaling pathway in JAM-C(+) B cells. PMID: 27256571
    4. blocking JAM-C can reduce the number of atherogenic monocytes/macrophages in plaques by emigration. PMID: 27442505
    5. Palmitoylation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549 lung cancer cells. PMID: 28196865
    6. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils. PMID: 26841848
    7. Suggest JAM3-M4 methylation as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix. PMID: 26517242
    8. JAM-C inactivation in endothelial cells resulted in increased spreading on fibronectin and enhanced sprouting in vitro in a manner dependent on beta1-integrin and on the activation of the small GTPase RAP1. PMID: 26311310
    9. indicate that JAM-C may be a therapeutic target for preventing and treating lymphatic metastases PMID: 24584816
    10. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer. PMID: 23825230
    11. Our study confirms the importance of JAM3 as a component of the junctional complexes and its deficiency leading to a distinctive and catastrophic neonatal presentation of cataracts and hemorrhagic destruction of the brain. PMID: 23255084
    12. In the present study, we investigated the role of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodeficient mouse model. PMID: 23221386
    13. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis PMID: 21593193
    14. Our results suggest that JAM3 is essential for maintaining the integrity of the cerebrovascular endothelium as well as for normal lens development in humans PMID: 21109224
    15. Soluble JAM-C mediates facets of angiogenesis in vitro and contributes the angiogenic potential of rheumatoid arthritis synovial fluid. PMID: 20592283
    16. Letter: investigated platelet JAM-C following platelet activation by several agonists. PMID: 20135068
    17. molecular cloning & role as VE-JAM/JAM 2 receptor PMID: 11823489
    18. JAM3 is a strong candidate gene for hypoplastic left heart syndrome PMID: 11944976
    19. Facilitates JAM2 interaction with alpha4beta1 PMID: 12070135
    20. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. PMID: 12208882
    21. JAM-C(3) MAY play a role in desmosomal structure/function. PMID: 15194813
    22. JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies PMID: 15485832
    23. Junctional adhesion molecule-C participates in the later steps of the leukoendothelial adhesion and transmigration cascade in an acute pulmonary inflammation model using transgenic mouse tissue overexpressing JAM-C. PMID: 15879142
    24. the homophilic interaction of JAM-C can mediate tumor cell-endothelial cell interactions and may have a role in tumor cell metastasis PMID: 16118203
    25. JAM-C is up-regulated by oxLDL and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis PMID: 16195363
    26. JAM-C is an integral component of the dermal fibroblast adherens-like junction, and co-localizes with ZO-1. PMID: 16916751
    27. Helps to regulate vascular permeability and pathologic angiogenesis through modulation of vascular endothelium (VE) contractility and VE-cadherin-mediated adhesion. PMID: 17116731
    28. the expression of JAM-C promotes metastasis by enhancing both the adhesion of cancer cells to extracellular matrices and the subsequent invasion PMID: 17227766
    29. expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C-lymphoproliferative syndromes and JAM-C+ ones PMID: 17429428
    30. The results of these studies suggest a role for JAM-C in the pathogenesis of arthritis. PMID: 17612407
    31. blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration PMID: 17625065
    32. Examine JAM-3 expression in normal/inflammed lymphatic endothelium. PMID: 17822725
    33. study shows JAM-C was expressed in human sural nerves with an expression profile similar to that seen in mice PMID: 18048693
    34. JAM-C *junctional adhesion molecule C) mediates recruiting and retaining leukocytes in the Rheumatoid arthritis synovium PMID: 18821692
    35. JAM-C expression is variable in different epithelial cell lines with co-localization at tight junctions. PMID: 19143587
    36. JAM-C gene expression is transcriptionally induced during activation of T lymphocytes via a calcineurin-dependent signaling pathway. PMID: 19204148
    37. The regulation of EC junctional integrity involves the coordinated and dynamic modification of localization and activity of junctional stabilizers such as the integrin beta(3) and the destabilizer, JAM-C. PMID: 19461049
    38. These studies suggest a function for coxsackievirus and adenovirus receptor (CAR) in male fertility. PMID: 16410001
    39. Functions as a facilitator for JAM2/alpha4beta1 interactions PMID: 12070135
    40. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. PMID: 11590146

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  • 相关疾病：
    Hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, desmosome. Cell junction, tight junction.; [Soluble form of JAM-C]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Detected on round and elongated spermatids (at protein level). Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (
  • 数据库链接：

    HGNC: 15532

    OMIM: 606871

    KEGG: hsa:83700

    UniGene: Hs.150718