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  4. Recombinant Human Junctional adhesion molecule A (F11R), partial

Recombinant Human Junctional adhesion molecule A (F11R), partial

  • 货号：
    CSB-YP897579HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP897579HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP897579HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP897579HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP897579HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD 321; CD321; CD321 antigen; ESTM33; F11 receptor; F11R; JAM 1; JAM A; JAM; JAM-1; JAM-A; JAM1; JAM1_HUMAN; JAMA; JCAM; Jcam1; Junction adhesion molecule 1; Junction adhesion molecule; mouse; homolog of; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM 1; PAM-1; PAM1; Platelet adhesion molecule 1; Platelet adhesion molecule; Platelet F11 receptor; PRO301; UNQ264
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
  • 基因功能参考文献：
    1. The functional diversity of JAM-A resides to a large part in a C-terminal PDZ domain binding motif which directly interacts with nine different PDZ domain-containing proteins. (Review) PMID: 29238845
    2. JAM-A was expressed in all gliomas included in this study. The JAM-A intensity increased with malignancy grade, while its prognostic value was limited. PMID: 28677106
    3. JAM-A protein plays protective role in pathogenesis of age related diseases as Atherosclerosis, Apoplexy, thrombosis, Hypertension, Ophthalmological pathology.Short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression leading to recovery of JAM-A synthesis in cells. PMID: 28509452
    4. Dysregulation of JAM-A via p63/GATA-3 signaling pathway occurs in squamous cell carcinomas of the head and neck. PMID: 27036044
    5. JAM family members differentially regulate CXCR4 function and CXCL12 secretion in the bone marrow niche. PMID: 26866290
    6. Our observations suggest that increased expression of JAM-A promotes neoplasia of lung adenocarcinoma. In addition, an anti-JAM-A antibody efficiently reduced cell proliferation and provoked apoptosis, indicating the potential feasibility of JAM-A-inhibitory cancer therapy. PMID: 28837251
    7. a new role for CD321 in endothelial cells PMID: 29028806
    8. We have shown that tension on JAM-A activates RhoA to control cell stiffness. Phosphorylation of JAM-A at S284 is required for activation of RhoA and increased cell stiffness in response to tension on the protein PMID: 26985018
    9. Using patient-derived glioblastoma cancer stem cells, we confirmed that JAM-A is suppressed by miR-145 PMID: 26374689
    10. Screening of a library of human cell surface membrane proteins showed that the Hom-1 vesivirus could utilize human junctional adhesion molecule 1 as a receptor to enter cells and initiate replication. PMID: 28196955
    11. Our results showed that APOC3 was closely associated with the inflammatory process in ECs, and that this process was characterized by the increased expression of TNF-alpha. Inflammatory processes further disrupted the tight junctions (TJs) between HUVECs by causing increased expression of JAM-1. PMID: 27619170
    12. High expression of junctional adhesion molecule-A and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients. PMID: 28231727
    13. JAM-A is one of the malignancy markers of HNSCC as well as beta-catenin in histopathology, and the plasma-soluble JAM-A may contribute to a serum diagnosis of HNSCC. JAM-A is a promising molecular target for diagnosis and therapy in HNSCC. PMID: 27115511
    14. F11R mrna expression was higher in rheumatoid arthritis patients, but promoter polymorphisms did not appear to be related to disease susceptibility. PMID: 26230081
    15. Data indicate that junctional adhesion molecule-A (JAM-A) is overexpressed in multiple myeloma (MM) cells and regulates reovirus sensitivity in MM. PMID: 26513296
    16. JAM-A regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. It triggers transient activation of Cdc42 and PI3K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the actin cytoskeleton. PMID: 26306570
    17. Data indicate that junctional adhesion molecule A (JAM-A) is a potential target of microRNA-495 {miR-495) in breast cancer cells. PMID: 25070379
    18. RNA interference mediated JAM-A gene silencing promotes human epidermal stem cell proliferation. PMID: 25471296
    19. JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects PMID: 25994236
    20. JAM-A promotes proliferation and inhibits apoptosis of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression. PMID: 25916097
    21. CD14(+)CD16(+) monocytes selectively transmigrated across our BBB model as a result of their increased JAM-A and ALCAM expression. PMID: 25420915
    22. Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis in nasopharyngeal cancer. PMID: 25416560
    23. Low JAM-A expression correlates with poor clinical outcome and promotes cell migration and invasion in gastric cancer. PMID: 25033702
    24. Redistribution of JAM-A in endothelial cells after stimulation with pro-atherogenic oxidized lipoproteins results in increased transmigration of mononuclear cells. PMID: 24704627
    25. trans-dimerization of JAM-A occurs at a unique site and with different affinity compared with dimerization in cis. Trans-dimerization of JAM-A may thus act as a barrier-inducing molecular switch that is activated when cells become confluent. PMID: 24672055
    26. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    27. the clinical significance of junctional adhesion molecule A (JAM-A) in patients with non-small cell lung cancer PMID: 24265754
    28. These studies establish F11R as a novel monocyte prognostic marker for GBM critical for defining a subpopulation of stromal cells for future potential therapeutic intervention. PMID: 24147027
    29. JAM-A(ov) MSCs migrated into the HF sheath and remodeled HF structure effectively. PMID: 24558164
    30. JAM-A recruits Csk to the integrin-c-Src complex, where Csk negatively regulates c-Src activation, thereby suppressing the initiation of outside-in signaling. PMID: 24300854
    31. The entry of HIV infected and uninfected CD14(+)CD16(+) monocytes into the brain was facilitated by significantly increased surface JAM-A, ALCAM, CD99, and PECAM-1, as compared to CD14(+) cells that are CD16 negative. PMID: 23922698
    32. Our data identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis. PMID: 24065611
    33. Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation. PMID: 23389628
    34. study concludes that JAM-A is co-expressed with HER2 and associates with aggressive breast cancer phenotypes; speculate that JAM-A may regulate HER2 proteasomal degradation and activity PMID: 22751120
    35. Sinonasal epithelium in allergic fungal rhinosinusitis displays increased epithelial permeability and an altered expression of junctional adhesion molecule A PMID: 22927233
    36. Low expression of junctional adhesion molecule A is associated with metastasis in pancreatic cancer PMID: 22549289
    37. Suggest a prognostic and possibly a pathogenic role of JAM-A in arterial hypertension. PMID: 22918977
    38. Data suggest that the Reovirus type 3 Dearing (T3D) jin mutants may be useful as oncolytic agents for use in tumors in which reovirus receptor Junction Adhesion Molecule-A (JAM-A) is absent or inaccessible. PMID: 23110175
    39. JAM-A can interfere with tumor proliferation and suggest that JAM-A is a potential novel target in oncology. PMID: 22886345
    40. TGF-beta1 treatment of MCF-7 cells significantly reduced JAM-A mRNA & protein via SMAD activation, & induced cell invasion. PMID: 22647687
    41. findings provide compelling evidence of a novel role for JAM-A in driving breast cancer cell migration via activation of Rap1 GTPase and beta1-integrin PMID: 21429211
    42. de novo synthesis of F11R in endothelial cells (EC) is required for the adhesion of platelets to inflamed ECs. PMID: 21703019
    43. downregulation of JAM-A reduces tumor aggressive behavior by increasing cell susceptibility to apoptosis PMID: 21695058
    44. these data identify JAM-A and fascin as novel targets of miR-145, firmly establishing a role for miR-145 in modulating breast cancer cell motility. PMID: 20818426
    45. In addition to the previously reported role of F11R in the initiation of plaque formation, F11R plays also an important role in the subsequent growth of atherosclerotic plaques. PMID: 20627246
    46. JAM-A expressed on CD34(+) progenitor cells regulates their adhesion to platelets or inflammatory endothelium under high shear stress in vitro and after carotid ligation in vivo or ischemia/reperfusion injury in the microcirculation of mice. PMID: 20378847
    47. LFA-1 binding to JAM-A destabilizes the JAM-A homophilic interaction and the greater strength of the LFA-1/JAM-A complex permits it to support the tension needed to disrupt the JAM-A homophilic interaction, allowing leukocyte transendothelial migration PMID: 18849408
    48. Two domains in the N-terminus and 1st Ig-fold of F11R were found, through which M.Ab.F11 triggers platelet aggregation. These 2 regions form an active site within the conformation of this cell adhesion molecule. PMID: 12008956
    49. platelets adhere specifically to F11R of cytokine- (TNF-alpha, INF-gamma) stimulated vascular endothelial cells PMID: 12428104
    50. signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis. PMID: 12750158

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed in endothelium, epithelium and leukocytes (at protein level).
  • 数据库链接：

    HGNC: 14685

    OMIM: 605721

    KEGG: hsa:50848

    STRING: 9606.ENSP00000289779

    UniGene: Hs.517293