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  4. Recombinant Human Interleukin-23 receptor (IL23R), partial

Recombinant Human Interleukin-23 receptor (IL23R), partial

  • 货号：
    CSB-YP733162HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP733162HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP733162HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP733162HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP733162HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IL 23R; IL-23 receptor; IL-23R; IL23 Receptor; Il23r; IL23R_HUMAN; Interleukin 23 receptor ; Interleukin-23 receptor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

问答及客户评论

■ 常见问题解答
Q:

Is it possible to have this protein with a myc-Tag ONLY?

A:
Thanks for your inquiry.Usually, our tag also contains the purification tag, such as his-tag.We usually produce the protein with an N-terminal tag and C-terminal Myc-tagged. If you only need myc-tag, we need to remove the N terminal tag. According to our experience, the success rate is 75%-86%. We can't 100% guarantee that the tag will be removed successfully.Our policy: The tag type will be determined during the production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
If we fail in developing the specified tag, we will send other tag types directly without negotiation.
Q:

Is there a molecular weight and which domains are included?

A:
Thanks for your inquiry. The express region of this protein is 24-355aa.This protein is the complete extracellular domain, containing the Fibronectin type-III 1 and Fibronectin type-III 2 Domain. The target protein molecular weight is 38KDa，the fusion protein's molecular weight will be confirmed after we confirm the expression plasmid.

靶点详情

  • 功能：
    Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • 基因功能参考文献：
    1. IL23R (rs10889677) polymorphism did not show any association with rheumatic heart disease in South Indian population PMID: 29985710
    2. Study confirms an association between IL12B and IL23R genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles). PMID: 29454820
    3. The IL23R gene rs10889677 A allele confers increased risk of ankylosing spondylitis (AS) in Europeans, but its role in Asian populations needs further exploration. PMID: 29198991
    4. these findings suggest that the variants +2199 A/C IL-23R and -197 G/A IL-17A could contribute to rheumatoid arthritis development in the studied population PMID: 28547498
    5. Data show that interleukin-23 receptor (IL-23R) single nucleotide polymorphism (SNP) rs11465817 contributes to the risk of recurrent oral ulceration (ROU) in Chinese. PMID: 29169427
    6. Findings indicate that IL17A -197 G/A and IL23R H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM. PMID: 28786198
    7. This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3, ABCB1 and IL23R) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk. PMID: 28422712
    8. genetic association studies in population in southwest China: Data suggest that SNPs in STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) are associated with occurrence, severity, and immunosuppressive therapy outcomes of aplastic anemia in the population studied. (STAT = signal transducer and activator of transcription) [article includes Meta-Analysis] PMID: 29330562
    9. Study provides a comprehensive examination of the available evidence for the association between polymorphisms in the IL-23R gene and ulcerative colitis (UC). The meta-analysis suggests that IL-23R gene polymorphisms are associated with UC susceptibility, especially in Caucasians. PMID: 27902482
    10. Data indicate that the interleukin-23 receptor (IL-23R) SNPs rs11209026, p.Arg381Gln; rs41313262 p.Val362Ile were not associated with susceptibility to inflammatory bowel disease (IBD) in Chinese Han population. PMID: 27765927
    11. Interleukin-23 receptor cytokine-binding homology region balances the ratio of Th17/Th9/Treg cells in collagen-induced arthritis. PMID: 27177334
    12. this meta-analysis suggests that each allele of IL-23R, including rs7519847, rs17375018 and rs11209032 was negatively associated with uveitis; however, homozygote models, including the rs17375018 GG genotype and rs11209032 AA genotype, were significantly associated with uveitis PMID: 28558665
    13. an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases (Review). PMID: 27043356
    14. Th17 cells expressed consistent high levels of the IL-12Rbeta1 subunit, which appeared a better predictor of responsiveness to IL-23 than the expression of the IL-23R subunit. PMID: 27645493
    15. We conclude that variants in IL-23A and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases. PMID: 27893410
    16. IL-23 R (rs7517847) and LEP (rs7799039) polymorphisms were associated with an increased risk but not affecting the clinical presentation of HCC among Egyptian patients PMID: 28452232
    17. In a Turkish population, IL23R polymorphism is a risk factor for UC and is protective against CD. PMID: 27852544
    18. The current study emphasizes the lack of association of IL23R and IL17 polymorphisms with rheumatoid arthritis susceptibility in the Algerian population. However, the data showed the relationship between IL23R and IL17A polymorphisms and the production of the different RF isotypes in rheumatoid arthritis patients PMID: 27606475
    19. Haplotype of non-synonymous IL-23R variants increase susceptibility to severe malarial anemia in children of a holoendemic P. falciparum transmission area. PMID: 28427357
    20. there is a positive association between the GWAS reported rs3762318 and leprosy, and SLC35D1 and IL23R might be the causal genes PMID: 27712858
    21. this study identified susceptibility single nucleotide polymorphisms in IL23R with Behcet's disease in Han Chinese PMID: 27464962
    22. HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci. PMID: 27548383
    23. Study identified a possible silencer downstream of IL23R that includes the ankylosing spondylitis (AS)-associated SNP rs924080, which appears to modulate the functional effects of this regulatory element; confirmed the primary association of AS with rs11209032 in this region, but suggest that there could be a possible additional effect from rs924080 in a putative silencer on the same haplotype. PMID: 28381868
    24. Study demonstrated susceptible or protective character of the investigated IL23R SNPs on the phenotype of ulcerative colitis, confirming the genetic association. PMID: 28210080
    25. In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R forms part of an enhancer, allelic variation of which may influence Th1-cell numbers. PMID: 26916345
    26. Results did not show any strong association between IL-23R polymorphisms and juvenile idiopathic arthritis or serum IL-17A levels in Iranian patients. PMID: 26016922
    27. The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2 and IL23R make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations PMID: 26987707
    28. this study shows a lack of association of the IL-23 single nucleotide polymorphisms with the risk of acute lymphoblastic leukemia in Iran PMID: 28341819
    29. The interleukin-23 receptor gene polymorphism may not contribute to the susceptibility of development of primary immune thrombocytopenia in Egyptian children. PMID: 26859125
    30. this study shows that there is no significant difference in mucosal IL-23R expression in Ulcerative Colitis patients with moderate-to-severe disease activity compared to those in remission PMID: 27178149
    31. In this study, we were unable to establish a correlation between the IL-23R SNPs investigated and HLA-B27-associated acute anterior uveitis as well as idiopathic intermediate uveitis. PMID: 27009486
    32. These results suggest that IL23R may contribute to the development of intracerebral hemorrhage. PMID: 26846416
    33. The association of IL-23R and Ankylosing Spondylitis (AS) that is seen in Caucasian patients with AS is not present in Chinese patients with AS. PMID: 27650612
    34. Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. PMID: 26961870
    35. genetic polymorphism is associated with psoriasis in the South Indian Tamils PMID: 26472011
    36. A significant association was found between all Crohn's disease and the rs7517847 polymorphism, especially in Caucasians. PMID: 26678098
    37. The IL23R polymorphisms rs10889677, rs7517847, and the IL12B polymorphism rs3212227 are not associated with multiple sclerosis risk. PMID: 26000455
    38. results suggest a convergent cause of IL23Ralpha variant protection against chronic inflammatory disease. PMID: 26887945
    39. meta-analysis supports that two polymorphisms (rs11209026 and rs7517847) in the IL-23 gene may be considered to be protective factors against developing UC among Caucasian populations. PMID: 25497273
    40. The results of the current study disclosers1343151 variant of IL23R as a susceptibility gene in CD. PMID: 25561320
    41. Lower LCN2 levels in Crohn's Disease patients carrying IBD risk-increasing IL23R variants may result from a restricted upregulation of LCN2 due to an impaired Th17 immune response PMID: 26263469
    42. IL23 receptor single nucleotide polymorphisms and gene copy number variation are associated with susceptibility to pulmonary tuberculosis in Chinese Uygurs. PMID: 26626589
    43. These results indicated an association between the rs11209026 G>A polymorphism of the IL-23 receptor gene and the risk of atherosclerosis. PMID: 26261042
    44. Low-Frequency IL23R Coding Variant is Associated with Crohn's Disease Susceptibility. PMID: 26375822
    45. R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma. PMID: 26547706
    46. GG genotype of the rs17375018 variant in the IL-23R gene enhances pro-inflammatory cytokine responses in Behcet's Disease. PMID: 26222305
    47. it is concluded that the frequency of single nucleotide polymorphism in the IL-23 receptor (R381Q) in patients with recurrent spontaneous abortion (RSA) is less than that found in normal control women. PMID: 26269135
    48. review and meta-analysis of association of polymorphisms rs6682925, rs10889677 and rs1884444 with cancer risk PMID: 26717375
    49. Copy number variation of exon 11 in IL-23R is associated with pulmonary tuberculosis in the Chinese Uygur population. PMID: 26829744
    50. IL-17A and IL-23R gene polymorphism were not associated with acute myeloid leukemia susceptibility. PMID: 26191290

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  • 相关疾病：
    Inflammatory bowel disease 17 (IBD17)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 组织特异性：
    Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
  • 数据库链接：

    HGNC: 19100

    OMIM: 607562

    KEGG: hsa:149233

    STRING: 9606.ENSP00000321345

    UniGene: Hs.677426