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  4. Recombinant Human Interleukin-17 receptor D (IL17RD), partial

Recombinant Human Interleukin-17 receptor D (IL17RD), partial

  • 中文名称：
    人IL17RD重组蛋白
  • 货号：
    CSB-YP847706HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人IL17RD重组蛋白
  • 货号：
    CSB-EP847706HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人IL17RD重组蛋白
  • 货号：
    CSB-EP847706HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人IL17RD重组蛋白
  • 货号：
    CSB-BP847706HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人IL17RD重组蛋白
  • 货号：
    CSB-MP847706HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IL17RD
  • Uniprot No.：
  • 别名：
    DKFZp434N1928; FLJ35755; hSef; I17RD_HUMAN; IL 17 receptor D; IL 17RD; IL-17 receptor D; IL-17RD; IL17 receptor D; il17rd; IL17Rhom; IL17RLM; Interleukin 17 receptor D; Interleukin 17 receptor like protein; Interleukin-17 receptor D; Interleukin-17 receptor-like protein; Interleukin17 receptor D; MGC133309; SEF; Sef homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
  • 基因功能参考文献：
    1. miR-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population PMID: 28600480
    2. Low SEF expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer. PMID: 26950413
    3. Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT. PMID: 28073170
    4. IL17RD negatively regulates Toll-like receptor (TLR)-induced responses. PMID: 25808990
    5. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms. PMID: 25118304
    6. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis. PMID: 24681741
    7. These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells. PMID: 23770285
    8. FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism. PMID: 23643382
    9. Downregulation of SEF mRNA is associated with prostate cancer. PMID: 23169297
    10. Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. PMID: 23047677
    11. This study establishes Sef as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases. PMID: 22975329
    12. The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased. PMID: 22335910
    13. Findings indicate that Ras-induced nuclear accumulation of activated MEK1/2 was reliant on downregulation of the spatial regulator Sef. PMID: 22298595
    14. Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling PMID: 12604616
    15. human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis PMID: 12807873
    16. HSef acts as a spatial regulator for ERK signaling by targeting ERK to the cytoplasm. PMID: 15239952
    17. Sef binds to TAK1 and has a role in JNK activation and apoptosis PMID: 15277532
    18. Sef is downregulated in advanced prostate cancer and might facilitate an enhanced tumorigenic response to FGFs PMID: 16474841
    19. Sef inhibited FGF induced, but not RasG12V mediated, signal transduction. We propose that Sef interacted with Ras in the inhibition of Ras/MAPK signaling pathway. PMID: 16859641
    20. hSef isoforms can control signal specificity and subsequent cell fate by utilizing different mechanisms to modulate RTK signaling PMID: 17035228
    21. Inhibitory effect of hSef on cell proliferation combined with consistent downregulation in human carcinoma indicates a tumor suppressor-like role for Sef. PMID: 17420726
    22. Sef plays a positive role in the EGF/EGFR-mediated MAPK signaling pathway. PMID: 18096367
    23. IL 17RD protein is a part of the Interleukin-17 receptor signaling complex, therefore providing novel evidence for Interleukin-17 signaling through a heteromeric and/or homomeric receptor complex. PMID: 19079364
    24. CUG codon functions as a major translation initiation site in the alternatively spliced transcript variant hSef-b. PMID: 14742870

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  • 相关疾病：
    Hypogonadotropic hypogonadism 18 with or without anosmia (HH18)
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; [Isoform 4]: Cytoplasm.
  • 组织特异性：
    Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting
  • 数据库链接：

    HGNC: 17616

    OMIM: 606807

    KEGG: hsa:54756

    STRING: 9606.ENSP00000296318

    UniGene: Hs.150725