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  4. Recombinant Human Interferon regulatory factor 5 (IRF5)

Recombinant Human Interferon regulatory factor 5 (IRF5)

  • 货号：
    CSB-YP011820HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011820HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011820HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011820HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011820HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Interferon regulatory factor 5; Interferon regulatory factor 5 bone marrow variant; IRF 5; IRF-5; Irf5; IRF5_HUMAN; SLEB10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-498
  • 氨基酸序列
    MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
  • 基因功能参考文献：
    1. A possible cross-reaction between IRF5/EBV homologous antigens and shifts in T cell balance disrupted by anti-IL-2 Abs. PMID: 29379122
    2. study suggests a novel role for interferon regulatory factor 5 (IRF5) in the regulation of the inflammatory response in human myometrium PMID: 30006439
    3. In IAV-infected patients, miR-302a expression was down-regulated, whereas IRF-5 expression was up-regulated. Taken together, this work uncovers and defines a signaling pathway implicated in an IAV-induced cytokine storm. PMID: 29046356
    4. Analysis of clinical HCC specimens supports a pathologic role for IRF5 in HCV-induced HCC, as IRF5 expression was down-regulated in livers from HCV-positive versus HCV-negative HCC patients or healthy donor livers. These results identify IRF5 as an important suppressor of HCV replication and HCC pathogenesis. PMID: 29079574
    5. Results indicated that IFR5 variants rs77571059 and rs2004640 and haplotype GTAA were associated with the susceptibility to CAP and rs77571059 was related to the severity of the disease, suggesting that IFR5 variants may contribute to the pathogenesis of community-acquired pneumonia (CAP), and may serve as prognostic markers of CAP susceptibility and outcome. PMID: 30176312
    6. IRF5 and its related inflammatory cytokines are associated with the severity, prognosis, and causative pathogen of CAP patients. PMID: 29847542
    7. this study shows that interferon regulatory factor 5 regulates the expression of matrix metalloproteinase-3 in human chondrocytes PMID: 29274624
    8. IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. PMID: 29375210
    9. The presence of the interferon regulatory factor 5 rs2004640 T allele increases the risk of nephritis development in Egyptian children with systemic lupus erythematosus. PMID: 28059021
    10. IRF5 was an adverse independent prognostic factor for both overall survival and recurrence free survival in patients with non-metastatic ccRCC. PMID: 28562332
    11. Data suggest that IRAK4 activity regulates activation of IRF5, TAK1, and IKKB in monocytes; IRAK4 activation of TAK1-IKKB-IRF5 axis leads to induction of cytokines and interferons following TLR7/TLR8 stimulation. (IRAK4 = interleukin-1 receptor-associated kinase 4; IRF5 = interferon regulatory factor-5; TAK1 = MAPK kinase kinase 7; IKKB = I-kappa B kinase; TLR = toll-like receptor) PMID: 28924041
    12. IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation. PMID: 27545875
    13. the genomic pattern according to MATH demonstrated that mutation rates of TP53, IRF5 and KRAS were independently associated with MATH, and the latter two were only significant in male patients. As MATH increased, the fraction of somatic copy number alteration (SCNA) elevated. Moreover, more SCNA events was independently associated with MATH in male than in female PMID: 28531253
    14. IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1) at the transcriptional level by binding to its promoter. PMID: 28818665
    15. oncogenic IRF5 overexpression in HL is the result of a specific LTR transcriptional activation PMID: 26279299
    16. the primary activating regulatory region of human IRF5 was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 was able to bind to the multiple sites in IRF5 promoter region, and was involved in the transcriptional regulation of IRF5 at the basal level. PMID: 27484157
    17. This study demonstrates the association of IRF5 with an increased susceptibility for systemic lupus erythematosus (SLE) in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. Patients carrying allele the Neanderthal allele C had greater type I IFN, supporting a functional consequence of this polymorphism. PMID: 28185859
    18. this study shows that IRF5 polymorphisms are associated with unexplained recurrent pregnancy loss among Iranian women PMID: 27798840
    19. The results demonstrated that STAT4 rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis. PMID: 26712637
    20. IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. PMID: 27092776
    21. IRF5 and IRF8, two transcription factors with opposing functions, control TLR9 signaling in human plasmacytoid dendritic cells. PMID: 26613957
    22. meta-analysis demonstrated the IRF5 rs2070197 polymorphism conferred susceptibility to systemic lupus erythematosus (SLE) in all subjects without inter-study heterogeneity; IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations but it had no effects in Asians PMID: 26233721
    23. Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus PMID: 26294277
    24. four single nucleotide polymorphisms studied in IRF5 may affect neither Neuromyelitis optica nor Multiple sclerosis in the Southeastern Han Chinese population PMID: 26112714
    25. h Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis epitopes of IRF5 elicit a consistent humoral response in multiple sclerosis patients PMID: 25392335
    26. Study indicates that high-level IRF-5 expression is specific to HTLV-1-infected T cells and regulated by Tax viral protein. PMID: 26004104
    27. the data demonstrate a critical mechanism by which sex differences in basal plasmacytoid dendritic cell IRF5 expression lead to higher IFN-alpha production upon TLR7 stimulation in females. PMID: 26519527
    28. regulates CXCL13-mediated recruitment of B and T cells to IRF5-positive tumor-conditioned media PMID: 25533286
    29. The polymorphisms in the IRF5 gene may play a role in the development of Crohn's Disease in the Malaysian population, as seen in the significant associations of SNPs, that is, rs3807306, rs10954213 and rs11770589. PMID: 25564941
    30. study gives no definite evidence for a pathogenic genetic link of periodontitis and RA but suggests IRF5 and PRDM1 as shared susceptibility factors. PMID: 25263394
    31. IRF5-TNPO3 genetic variation is associated systemic lupus erythematosus. PMID: 25205108
    32. A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism. PMID: 25649192
    33. IRF-5 is suppressed by hypermethylation of its promoter-A in most of EBV-infected transformed cells, especially Burkitt's lymphomas and EBV-associated gastric carcinoma (EBVaGC) PMID: 25557482
    34. We have found that three polymorphisms in linkage disequilibrium with the protective haplotypes of IRF5 have differential allele effects PMID: 23941291
    35. IRF5rs2004640 T (mutant) allele may be a susceptibility factor conferring risk for RA in South Indian Tamils, whereas G allele (wild type) may be protective. PMID: 25284481
    36. The association of IRF5 markers (rs2004640, rs10954213) with susceptibility to SLE and to the development of more than one autoimmune disease (OP) and to analyse the influence of rs2004640 on IRF5 isoform expression were explored PMID: 24697591
    37. TNFAIP3 and IRF5 polymorphisms were associated with polymyositis/dermatomyositis in Chinese Han patients with interstitial lung disease. PMID: 25337792
    38. gene variants in IRF5, IRF8 and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis PMID: 24943672
    39. Our results reveal that IRF5 gene variants are associated with risk of cardiovascular events in patients with Rheumatoid arthritis PMID: 25011482
    40. IKKbeta is an IRF5 kinase that instigates inflammation PMID: 25326420
    41. IKKbeta activates two "master" transcription factors of the innate immune system, IRF5 and NF-kappaB PMID: 25326418
    42. IRF5 is a key regulator in classical Hodgkin lymphoma, according to transcription factor motifs PMID: 25288773
    43. TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms. PMID: 25084355
    44. The IRF5's promoter polymorphisms alter first exon usage and increase transcription levels and high levels of IRF5 may bias the immune system toward autoimmunity. PMID: 24350899
    45. Polymorphisms of IRF5 may play an important role in susceptibility to systemic sclerosis. PMID: 25572744
    46. Meta-analysis certified that IRF5 polymorphisms confer susceptibility to systemic lupus erythematous, multiple sclerosis, and systemic sclerosis. PMID: 25036352
    47. results indicate that T3-bound TRs interfere with transactivation by TEADs via protein-protein interactions, resulting in the negative regulation of MYH7 promoter activity PMID: 24788560
    48. Unlike other studies, this study found no association of the rs2004640 SNP with SLE among Han Chinese. It did however interact with SNPS in ETS1, STAT4, and IKZF1. PMID: 24697319
    49. No significant association was found between all IRF5 SNPs (rs10954213, rs2004640, rs3807306, rs752637 and rs7808907) and ophthalmopathy in Graves' patients. PMID: 24582590
    50. This meta-analysis suggests that the A allele of rs10954213 and TCA haplotype (rs2004640-rs2070197-rs10954213) in IRF5 is associated with the increased risk of SLE in different ethnic groups, and its prevalence is ethnicity dependent. PMID: 23392701

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  • 相关疾病：
    Inflammatory bowel disease 14 (IBD14); Systemic lupus erythematosus 10 (SLEB10); Rheumatoid arthritis (RA)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IRF family
  • 数据库链接：

    HGNC: 6120

    OMIM: 180300

    KEGG: hsa:3663

    STRING: 9606.ENSP00000349770

    UniGene: Hs.521181