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  4. Recombinant Human Interferon regulatory factor 2-binding protein 1 (IRF2BP1)

Recombinant Human Interferon regulatory factor 2-binding protein 1 (IRF2BP1)

  • 中文名称：
    人IRF2BP1重组蛋白
  • 货号：
    CSB-YP815541HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人IRF2BP1重组蛋白
  • 货号：
    CSB-EP815541HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人IRF2BP1重组蛋白
  • 货号：
    CSB-EP815541HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人IRF2BP1重组蛋白
  • 货号：
    CSB-BP815541HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人IRF2BP1重组蛋白
  • 货号：
    CSB-MP815541HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IRF2BP1
  • Uniprot No.：
  • 别名：
    DKFZp434M154; I2BP1_HUMAN; Interferon regulatory factor 2 binding protein 1 ; Interferon regulatory factor 2-binding protein 1; IRF 2BP1 ; IRF-2-binding protein 1; IRF-2BP1; IRF2 binding protein 1; Irf2bp1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-584
  • 氨基酸序列
    MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
  • 基因功能参考文献：
    1. Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2. PMID: 12799427
    2. PCTA (IRF2BP1) defines a new component of the TGF-beta signalling pathway that functions to facilitate Smad2 phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2-receptor complex. PMID: 18511908
    3. IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter. PMID: 18671972
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    IRF2BP family
  • 数据库链接：

    HGNC: 21728

    OMIM: 615331

    KEGG: hsa:26145

    STRING: 9606.ENSP00000307265

    UniGene: Hs.515477