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  4. Recombinant Human Interferon-induced GTP-binding protein Mx1 (MX1)

Recombinant Human Interferon-induced GTP-binding protein Mx1 (MX1)

  • 货号：
    CSB-YP015249HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015249HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015249HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015249HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015249HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MX1
  • Uniprot No.：
  • 别名：
    Human interferon regulated resistance GTP binding protein MXA; IFI 78; IFI 78K; IFI-78K; IFI78; IFI78K; Interferon induced GTP binding protein Mx1 ; Interferon induced protein p78; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein; Interferon regulated resistance GTP binding protein MxA; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; MX 1; MX; MX dynamin-like GTPase 1; MX1; MX1_HUMAN; MxA; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78; Myxovirus (influenza) resistance 1 homolog of murine; Myxovirus resistance 1; mouse; homolog of; Myxovirus resistance protein 1; N-terminally processed
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-662
  • 氨基酸序列
    MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLVLK LKKLVNEDKW RGKVSYQDYE IEISDASEVE KEINKAQNAI AGEGMGISHE LITLEISSRD VPDLTLIDLP GITRVAVGNQ PADIGYKIKT LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH QRITEELQKY GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED IRLFTRLRHE FHKWSTIIEN NFQEGHKILS RKIQKFENQY RGRELPGFVN YRTFETIVKQ QIKALEEPAV DMLHTVTDMV RLAFTDVSIK NFEEFFNLHR TAKSKIEDIR AEQEREGEKL IRLHFQMEQI VYCQDQVYRG ALQKVREKEL EEEKKKKSWD FGAFQSSSAT DSSMEEIFQH LMAYHQEASK RISSHIPLII QFFMLQTYGQ QLQKAMLQLL QDKDTYSWLL KERSDTSDKR KFLKERLARL TQARRRLAQF PG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
  • 基因功能参考文献：
    1. MxA conformational dynamics through GTP hydrolysis revealed by single-molecule fluorescence resonance energy transfer. PMID: 28548099
    2. IL28B and MxA gene genotypes were detected among 231 chronic hepatitis C (CHC) carriers, 428 subjects with hepatitis C virus spontaneous clearance and 662 CHC patients with pegylated IFN-alpha and ribavirin (pegIFN-alpha/RBV) treatment. PMID: 29271328
    3. Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis. PMID: 28139728
    4. MxA inhibits hepatitis C virus replication through JAK-STAT pathway activation. PMID: 29417241
    5. findings indicated that MxA over-expression inhibited HCV replication and potentiated the IFNalpha-mediated anti-HCV activity; MxA stimulated the production of IFNalpha, IFNbeta, and enhanced IFNalpha-induced activation of Jak-STAT signaling pathway; concluded that MxA is a positive regulator of type I IFN signaling in HCV infection PMID: 28561372
    6. Relative expression of OAS1 and Mx1 in patients with recurrent forms of Herpes simplex both during the acute stage and clinical remission did not differ significantly from that in healthy people after stimulation with IFN-alpha2b. PMID: 28744639
    7. Study demonstrated associations between rs464138 AA genotype in MxA gene and IFNbeta responsiveness in multiple sclerosis patients. However, the allele and genotype frequencies of other SNPs were not significantly different among patient subtypes or between patients and controls. Besides, results demonstrated that CGC, ATA, and AGA (-123, -88, +20) haplotypes were significantly associated with IFNbeta response in MS pa... PMID: 28386647
    8. High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. Additionally, a high level of TILs was a prognostic factor for breast cancer, whereas the level of MxA expression had no prognostic value. PMID: 27456948
    9. studied the susceptibility of Vaccinia virus and Cowpox viruses to MxA antiviral action, and concluded that these viruses are not affected by the antiviral action of MxA PMID: 28727764
    10. Here, the s show that for North African patients with chronic hepatitis, MX1 gene variation at position -123 may influence the outcome of hepatitis B virus infection but not hepatitis B virus infection. PMID: 27458866
    11. the data identify MxA as a novel stimulator of BMP4 and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases. PMID: 27875556
    12. This study provides Class II evidence that immunohistochemistry-detected sarcoplasmic MxA expression accurately identifies patients with dermatomyositis (DM): sarcoplasmic MxA expression detected by immunohistochemistry is a more sensitive marker of DM than the conventional hallmarks PMID: 28039312
    13. A significant association was observed between MX1 -88G/T SNP and susceptibility to systemic lupus erythematosus PMID: 26815367
    14. Study shows different levels of expression of MxA in each breast cancer subtype and its close relationship with tumor-infiltrating lymphocytes. MxA protein expression was higher in triple-negative breast cancer and correlated with a higher histologic grade. PMID: 27075916
    15. This study demonstrated that MxA mRNA expression of interferon beta response in multiple sclerosis patients. PMID: 26857498
    16. Transient dimerization of human MxA promotes GTP hydrolysis.The GTPase domains of Mx proteins dimerize transiently to facilitate catalysis. PMID: 25295396
    17. polymorphism at position -88 in the MxA promoter region might be a potential biomarker to predict HCV progression toward end-stage fibrosis and response to IFN-based therapy in chronic hepatitis C patients. PMID: 25868067
    18. data suggest that, during infection, a fraction of MxA disassembles into dimers that bind to NP synthesized following primary transcription in the cytoplasm, thereby preventing viral replication PMID: 26507657
    19. heterozygosity for both -88G/T and -123C/A polymorphisms of the MxA gene is important host factor that influence the response to IFN therapy in patients with chronic HCV infection. PMID: 25239021
    20. E2F1 transcripts and miR-17-5p were significantly downregulated while c-Myc and MxA transcripts were significantly upregulated in SLE. PMID: 26175399
    21. Baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta treatment. PMID: 25396411
    22. upregulated in the skin of Lichen planus patients PMID: 25384438
    23. Blood MxA protein levels are increased in young children with symptomatic respiratory virus infections, including rhinovirus infections. MxA is an informative general marker for the most common acute virus infections. PMID: 25542463
    24. Reovirus T3D infection induced STAT-1, ISG-15, IFIT-1, Mx1, and IFIT-3 expression. PMID: 25905045
    25. study highlights the role of nucleotide binding and hydrolysis for the intracellular dynamics of MxA during its antiviral action. PMID: 25829498
    26. These data warrant the quantification of MxA mRNA as a primary tool for a routine monitoring of IFNbeta therapy. PMID: 24733382
    27. MxA expression is inversely correlated with prostate cancer. Down-regulation of MxA in LNCaP cells by DHT suggests that MxA could play a significant role in disease progression. PMID: 25327819
    28. MxA interacts with Ubc9 and SUMO1 in a yeast two-hybrid system. PMID: 25447205
    29. These studies disclosed that antiviral IFN-induced MxA and APOBEC3G/3F mRNA levels were increased after IL-32gamma treatment of peripheral blood mononuclear cells. PMID: 24553842
    30. Plasmacytoid dendritic cells in the infiltrate of progressive vitiligo produce MxA. Strong MxA expression was seen in perilesional skin near remaining melanocytes, surrounded by a prominent T-cell infiltrate, but it was not detectable in lesional skin. PMID: 24438589
    31. MX1 may have a role in lymph node metastasis in colorectal carcinoma PMID: 24771638
    32. It describes the standardized cellular myxovirus resistance protein A (MxA) protein measurement-based assay for detection of IFN-beta NAbs and its use for the validation of assays used for the quantitative determination of such antibodies. PMID: 23848523
    33. antiviral innate immunity may be involved in mesangial cells (MCs) of lupus nephritis patients, which results in the expression of Mx1 in MCs. PMID: 24674141
    34. Varicella-zoster virus inhibits the nuclear translocation of phosphorylated-STAT1 and antiviral MX1 protein expression in human brain vascular adventitial fibroblasts. PMID: 25056900
    35. Upregulation of MxA expression during the early stages of Graves disease, and the correlation between the number of PDCs and MxA+ leucocytes, suggests that activated PDCs secrete type I IFNs at the lesion site, possibly in response to viral infection. PMID: 24032645
    36. protein expression is inhibited by hepatitis C virus PMID: 23529855
    37. The L4 loop of the stalk domain of MX1 is a critical determinant. PMID: 24899177
    38. MxA protein levels in whole blood and monocytes correlated with primary Sjogren's syndrome disease activity and IFN type I bioactivity. PMID: 23831963
    39. Hepatitis C genotype 1 patients who were responders to interferon-based therapy had a high frequency of multiple protective polymorphisms in the myxovirus resistance protein, osteopontin and suppressor of cytokine signaling 3 genes. PMID: 24212839
    40. Data indicate susceptibility genes including myxovirus (influenza virus) resistance 1 (MX1) for respiratory syncytial virus (RSV) disease severity and risk. PMID: 24421397
    41. polymorphisms in the MxA promoter may play a role in mediating the susceptibility to enterovirus 71 infection in Chinese population PMID: 24085612
    42. Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus. PMID: 24448803
    43. Studied the association of the functional polymorphism rs2071430 in MxA with prostate cancer.A significant association was observed between rs2071430 genotype GG and prostate cancer. Individuals with the GG genotype have increased risk of prostate cancer. PMID: 23438650
    44. these results show that allelic diversity in the MxA gene proximal promoter significantly alter the tight regulation of antiviral MxA protein expression by type-I and type-III interferons. PMID: 22985419
    45. MxA protein sequestered the West Nile virus capsid protein in cytoplasmic tubular structures and resulted in reduced titers of secreted virus particles. PMID: 24314641
    46. Interferon-induced MxA protein inhibits influenza A virus infection by retaining the incoming viral genome in the cytoplasm. PMID: 24049170
    47. myxovirus resistance protein A expression is increased in thyroid tissue in the early stages of Hashimoto's thyroiditis PMID: 22998463
    48. IL-17A but not IL-22 suppresses the replication of hepatitis B virus by inducing the expression of MxA and OAS. PMID: 23274784
    49. This is the first study showing the significant association of MxA SNPs and predisposition of AD, modulation of AAO in AD, and rate of cognitive decline. PMID: 22950423
    50. The MxA-88T/-123A gene variants indirectly increase the risk for heptaitis C virus infection. PMID: 23232524

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 数据库链接：

    HGNC: 7532

    OMIM: 147150

    KEGG: hsa:4599

    STRING: 9606.ENSP00000381599

    UniGene: Hs.517307