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  4. Recombinant Human Inositol monophosphatase 2 (IMPA2)

Recombinant Human Inositol monophosphatase 2 (IMPA2)

  • 货号：
    CSB-YP011695HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011695HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011695HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011695HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011695HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IMP 2; IMP A2; IMP.18P; IMP2; IMPA 2; Impa2; IMPA2_HUMAN; IMPase 2; Inosine monophosphatase 2; Inositol 1; Inositol 1(or 4) monophosphatase 2; Inositol monophosphatase 2; Inositol monophosphatase 2 variant 1; Inositol monophosphatase 2 variant 2; Inositol(myo) 1(or 4) monophosphatase 2 ; Inositol-1(or 4)-monophosphatase 2; Myo inositol monophosphatase A2 ; Myo-inositol monophosphatase A2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-288
  • 氨基酸序列
    MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
  • 基因功能参考文献：
    1. IMPA2 is a protein-coding gene for a catalytic protein that converts inositol monophosphate into free inositol through dephosphorylation. PMID: 29499505
    2. a correlation between an IMPA2 polymorphism rs589247 and ischemic stroke risk in a northwest Han Chinese PMID: 27661109
    3. a promoter polymorphism of IMPA2 possibly contributed to risk for schizophrenia by elevating transcription activity in Han Chinese individuals. PMID: 27748550
    4. results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients. PMID: 23453640
    5. s propose that the human myo-inositol monophosphatase 2 interacts with myo-inositol monophosphates in the three-metal-ion bound form, and proceeds the dephosphorylation through the three-metal-ion theory. PMID: 21213002
    6. No association is found between IMPA2 gene polymorphisms and bipolar disorder. PMID: 20800640
    7. Promoter is polymorphic in bipolar disorder. PMID: 14699425
    8. IMPA2 may be a febrile seizure susceptibility gene. 6 SNPs were found: -708G/A, -461C/T, IVS1-15G/A, 159T/C, IVS5+13-14insA, & 558C/T. PMID: 15557493
    9. the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations. PMID: 17251911
    10. The crystal structures of human IMPA2 are useful for understanding the effect of nonsynonymous polymorphism reported in IMPA2, and will contribute to further functional analyses of IMPA2. PMID: 17340635
    11. data suggest that the genetic variants in the IMPA2 gene are not associated with a risk of febrile seizures in Caucasian patients and patients from various genetic groups are likely to have different genetic causes of febrile seizures PMID: 17388992
    12. Single nucleotide polymorphism in IMPA2 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
    13. The product of this gene has been functionally characterized as the U7 snRNP-associated Sm-like protein Lsm11 PMID: 14624008

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  • 蛋白家族：
    Inositol monophosphatase superfamily
  • 数据库链接：

    HGNC: 6051

    OMIM: 605922

    KEGG: hsa:3613

    STRING: 9606.ENSP00000269159

    UniGene: Hs.743311