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  4. Recombinant Human Inhibitor of growth protein 2 (ING2)

Recombinant Human Inhibitor of growth protein 2 (ING2)

  • 货号：
    CSB-YP867125HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP867125HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP867125HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP867125HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP867125HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ING2
  • Uniprot No.：
  • 别名：
    ING 1 like tumor suppressor protein; ING 1L; ING 2; ING1 like tumor suppressor protein; ING1L; ING1Lp; ING2; ING2_HUMAN; Inhibitor of growth 1 like; Inhibitor of growth 1 like protein; Inhibitor of growth 1-like protein; Inhibitor of growth family member 1 like; Inhibitor of growth family member 2; Inhibitor of growth protein 2; p32; p33 ING2; p33ING2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-280
  • 氨基酸序列
    MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
  • 基因功能参考文献：
    1. The ING1L gene may be involved in basal cell carcinogenesis. PMID: 15005689
    2. P33ING2 cooperates with p53 to regulate apoptosis via activation of both the mitochondrial/intrinsic and death-receptor/extrinsic apoptotic pathways. PMID: 15748897
    3. ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence. PMID: 16024799
    4. The expression of ING2 was down-regulated in 6 of 7 lung cancer cell lines that had a p53 mutation. PMID: 16465410
    5. Observations suggest that p33ING2 is required for the initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process. PMID: 16488987
    6. The data showed that nuclear ING2 expression was significantly reduced in radial growth phase (RGP), vertical growth phase (VGP), and metastatic melanomas compared with dysplastic nevi (P < 0.05). PMID: 16755297
    7. Deletion of leucine zipper-like (LZL)abrogated the association between ING2 and p53, suggesting that ING2 modulates p53-dependent chromatin remodeling, apoptosis and DNA repair. PMID: 16782091
    8. molecular modeling and docking of the 5-methylenephosphonate or 5-phosphothionate analogues to the C-terminus PtdInsP-binding region of ING2 revealed a number of complementary surface and electrostatic contacts between the lipids and ING2 PMID: 17469822
    9. p33ING2/ING1L is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation. PMID: 11481424
    10. Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
    11. ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis. PMID: 26717876
    12. Results suggest that ING2 acts as a tumor suppressor in osteosarcoma. PMID: 25190103
    13. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor. PMID: 25613071
    14. Decreased expression of ING2 gene is associated with non-small cell lung cancer. PMID: 24712846
    15. It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer. PMID: 23864195
    16. findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites PMID: 23823870
    17. Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men. PMID: 21124965
    18. Data show that inhibition of ING2 expression accelerates progression of cells from G(1) to S-phase, and is accompanied by a decrease of p21 expression, and that regulation of p21 by ING2 is independent of p53. PMID: 20890119
    19. expression is downregulated in non-small cell lung carcinoma PMID: 19962781
    20. sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions PMID: 20676127
    21. Decreased expression of ING2 gene is associated with hepatocellular carcinoma PMID: 18160212
    22. ING2 collaborates with SnoN to mediate TGF-beta-induced Smad-dependent transcription and cellular responses PMID: 18334480
    23. p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway. PMID: 18451145
    24. ING2 C-terminus recruits histone methyltransferase activity, which correlates with silencing function PMID: 18513492
    25. ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. PMID: 18951897
    26. ING2 loss of heterozygosity is associated with advanced staging in head and neck squamous cell carcinoma and determines survival rate. PMID: 18998165
    27. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. PMID: 19437536
    28. found that ING2 interacts with proliferating cell nuclear antigen and regulates its amount to the chromatin fraction, allowing normal replication progression and normal cell proliferation. PMID: 19730436

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  • 亚细胞定位：
    Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
  • 蛋白家族：
    ING family
  • 组织特异性：
    Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
  • 数据库链接：

    HGNC: 6063

    OMIM: 604215

    KEGG: hsa:3622

    STRING: 9606.ENSP00000307183

    UniGene: Hs.107153