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  4. Recombinant Human Inhibitor of growth protein 1 (ING1)

Recombinant Human Inhibitor of growth protein 1 (ING1)

  • 中文名称：
    人ING1重组蛋白
  • 货号：
    CSB-YP891532HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ING1重组蛋白
  • 货号：
    CSB-EP891532HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ING1重组蛋白
  • 货号：
    CSB-EP891532HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ING1重组蛋白
  • 货号：
    CSB-BP891532HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ING1重组蛋白
  • 货号：
    CSB-MP891532HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ING1
  • Uniprot No.：
  • 别名：
    2610028J21Rik; AA407184; AI875420; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds ; ING 1; Ing1; ING1_HUMAN; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; mING1h; OTTHUMP00000018703; OTTHUMP00000018704; OTTHUMP00000018705; OTTHUMP00000018706; p24ING1c; p33; p33 ING1; p33ING1; p33ING1b; p33ING1c; p37Ing1b; p47; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-422
  • 氨基酸序列
    MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY NR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
  • 基因功能参考文献：
    1. The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. PMID: 29222185
    2. Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells. PMID: 29729696
    3. Results from a study on gene expression variability markers in early-stage human embryos shows that ING1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    4. Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
    5. ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor. PMID: 27903908
    6. a novel corepressor function of ING1b on various AR functions, thereby inhibiting prostate cancer cell growth. PMID: 26993046
    7. ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence. PMID: 26439691
    8. These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer PMID: 26306560
    9. Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. PMID: 25613480
    10. Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR-371-5p involved in miR-371-5p inducing promotion of PDAC cells proliferation. PMID: 25411783
    11. ING1b sumoylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. PMID: 24903338
    12. Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival PMID: 24912621
    13. Ing1b lacking cells showed decreased ability to repair the oxidized DNA. PMID: 24242916
    14. ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. PMID: 24008732
    15. ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms. PMID: 23459830
    16. Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present. PMID: 23585863
    17. Data identify a pathway by which ING1a induces senescence and indicate that altered endocytosis activates the Rb pathway, subsequently effecting a senescent phenotype. PMID: 23472054
    18. ING1b epigenetically regulates several miRNAs including miR-203. PMID: 23462723
    19. the reduced expression of p33(ING1b) in gastric adenocarcinoma tissues and gastric adenocarcinoma cell lines PMID: 22237655
    20. inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation PMID: 23388825
    21. ING1 gene mutations are rare in laryngeal squamous cell carcinoma. PMID: 22260079
    22. Data suggest that the combined detection of p33ING1, p53, and Beclin1 genes and proteins will be helpful for early diagnosis and prognosis judgment for NSCLC, and can provide experimental evidence for biotherapy of NSCLC. PMID: 21779982
    23. Data show that overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in fibroblasts. PMID: 21896275
    24. ING1 stabilizes p53 by inhibiting polyubiquitination of multimonoubiquitinated forms via interaction with and colocalization of the HAUSP-deubiquitinase with p53. PMID: 21731648
    25. AZT upregulates the expression of p33ING1b, a possible mechanism in regulating senescence and apoptosis of TJ905 cells. PMID: 21176536
    26. Data show that ectopic expression of miR-622 promoted invasion, tumorigenesis and metastasis of gastric cancer cells, and that ING1 is a direct target of miR-622. PMID: 21528065
    27. p33ING1 triggers a senescent phenotype in cultured primary fibroblasts in a p53-dependent fashion. PMID: 21078114
    28. relocation of p33ING1b from the nucleus to the cytoplasm, where the protein is tethered by 14-3-3eta, participates in tumorigenesis and progression in HNSCC PMID: 21432775
    29. Loss of ING1 is associated with non-small cell lung cancer. PMID: 21286670
    30. ING1 proteins regulate the expression of proteins that are critical for angiogenesis in glioblastoma multiforme (GBM) such as the angiopoietins. PMID: 20066899
    31. ING1 in normal and neoplastic tissues. PMID: 11991811
    32. PBLs from pts with haematological malignancies and controls expressed mainly the p33/ING1 transcript, with low levels of p24/ING1 and p33/ING1 mRNA were found. Genetic changes in p33/ING1 play no role in these malignancies. PMID: 12008079
    33. role in differential regulation of histone acetylation PMID: 12015309
    34. Data suggest that p33(ING1) cooperates with p53 in UVB-induced apoptosis via the mitochondrial cell death pathway in melanoma cells. PMID: 12243754
    35. overexpression and mutation of the ING1 gene are infrequent in human basal cell carcinoma PMID: 12632089
    36. ING1 expression is frequently associated with adenocarcinoma of the esophagogastric junction tumorigenesis, further supporting its role as a tumor suppressor gene, and ING1 expression is independent of p53 status PMID: 12637159
    37. ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer PMID: 14581367
    38. Deregulated expression and mislocalization of ING1 proteins are common events in gliomas and glioblastomas PMID: 14676120
    39. ING1 mutations abrogate its enhancement in nucleotide excision repair in melanoma. PMID: 15201991
    40. Decreased expression of the candidate tumor suppressor gene ING1 is associated with advanced neuroblastomas PMID: 15375504
    41. ING tumor suppressors are involved in signalling pathways [review] PMID: 15526165
    42. Mutation and loss of expression are not the main reasons for the disfunction of p33(ING1b) in pancreatic carcinoma PMID: 15534913
    43. p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras PMID: 15601862
    44. p33ING1b enhances taxol-induced apoptosis through p53-dependent pathway in human osteosarcoma cells; p33ING1b may be an important marker and/or therapeutic target in the prevention and treatment of osteosarcoma PMID: 15662138
    45. Down regulation of p33ING1b is associated with the pathogenesis of ovarian cancers PMID: 15677627
    46. Loss or inactivation of p33(ING1b) normal function may be an important mechanism for the development of hepatocellular carcinoma retaining wild-type p53. PMID: 15800978
    47. p33(ING1b) and p47(ING1a) mRNA expressions are closely related with the carcinogenesis and progression of human sporadic colorectal cancer PMID: 16273637
    48. p33ING1b prominently enhances etoposide-induced apoptosis through p53-dependent pathways in human osteosarcoma cells. PMID: 16325212
    49. ING1 expression was up-regulated in all 7 lung cancer cell lines that had a p53 mutation. PMID: 16465410
    50. Subcellular targeting of ING1 by phosphorylation-dependent 14-3-3 binding regulates P21 expression. PMID: 16581770

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  • 相关疾病：
    Squamous cell carcinoma of the head and neck (HNSCC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ING family
  • 组织特异性：
    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and c
  • 数据库链接：

    HGNC: 6062

    OMIM: 275355

    KEGG: hsa:3621

    STRING: 9606.ENSP00000364929

    UniGene: Hs.46700