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  4. Recombinant Human Inactive dipeptidyl peptidase 10 (DPP10), partial

Recombinant Human Inactive dipeptidyl peptidase 10 (DPP10), partial

  • 中文名称：
    人DPP10重组蛋白
  • 货号：
    CSB-YP839806HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DPP10重组蛋白
  • 货号：
    CSB-EP839806HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DPP10重组蛋白
  • 货号：
    CSB-EP839806HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DPP10重组蛋白
  • 货号：
    CSB-BP839806HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DPP10重组蛋白
  • 货号：
    CSB-MP839806HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DPP10
  • Uniprot No.：
  • 别名：
    Dipeptidyl peptidase 10 ; Dipeptidyl peptidase 10 non functional; Dipeptidyl peptidase IV related protein 3; Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase like protein 2; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2; Dipeptidylpeptidase 10; DPL 2; DPL2; DPP 10; DPP X; Dpp10; DPP10_HUMAN; DPPY; DPRP 3; DPRP-3; DPRP3; Inactive dipeptidyl peptidase 10; KIAA1492
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.
  • 基因功能参考文献：
    1. These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge. PMID: 29361513
    2. The DPP10 duplication is likely a benign CNV polymorphism enriched in Southern Chinese with a population frequency of ~1%. PMID: 28670437
    3. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry PMID: 26209633
    4. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials. PMID: 25600224
    5. study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility PMID: 25592153
    6. Our results suggest that DPP10(789) is involved in the pathology of AD and other neurodegenerative diseases. PMID: 25025038
    7. demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels PMID: 22387313
    8. Crystals of DPP10 obtained by the sitting-drop method were orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 80.91, b = 143.73, c = 176.25 A. PMID: 22298003
    9. N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 channel/KCHIP2 complex activities. PMID: 20354865
    10. We were unable to confirm associations of single nucleotide polymorphisms of the positional candidates DPP10 and PHF11 with wheeze. Significant associations with reported and examined eczema were only observed for DPP10. PMID: 20085599
    11. Our study is the first one to provide additional evidence that supports the roles of DPP10 in influencing asthma or BHR in a Chinese population PMID: 19951440
    12. rs10208402 associated with percentage of peripheral blood eosinophils and log(e)-transformed total IgE in a Han Chinese population PMID: 19672052
    13. cloning, characterization and mapping to chromosome 2 PMID: 12662155
    14. Interaction between transmembranes of DPP10/DPPX and Kv4 channel mediates functional complex formation. We call this protein DPPY, instead of DPP10, because of its revealed role as a Kv4 channel regulator. PMID: 15911355
    15. although similar in structure and sequence to other dipeptidyl peptidases, it lacks vital residues required for dipeptidyl peptidase activity and has instead evolved features that enable it to act as a component of voltage-gated potassium channels PMID: 16290253
    16. Data show that in the Kv4.2+KChIP3+DPP10 channel complex, all DPP10 variants accelerate channel gating kinetics; however, the splice variant DPP10a produces uniquely fast inactivation kinetics that accelerates with increasing depolarization. PMID: 17475505
    17. No consistent association was found between DPP10 and asthma susceptibility. PMID: 17702965
    18. REVIEW: role in health and disease PMID: 19676137

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  • 相关疾病：
    Asthma (ASTHMA)
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase S9B family, DPPIV subfamily
  • 组织特异性：
    Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
  • 数据库链接：

    HGNC: 20823

    OMIM: 600807

    KEGG: hsa:57628

    STRING: 9606.ENSP00000376855

    UniGene: Hs.580539