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  4. Recombinant Human Homeobox protein Hox-B7 (HOXB7)

Recombinant Human Homeobox protein Hox-B7 (HOXB7)

  • 货号：
    CSB-YP010667HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010667HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010667HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010667HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010667HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXB7
  • Uniprot No.：
  • 别名：
    HOXB7; HOX2C; Homeobox protein Hox-B7; Homeobox protein HHO.C1; Homeobox protein Hox-2C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-217
  • 氨基酸序列
    MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. hsa_circ_0074362 plays a crucial role in glioma progression by regulating the miR-1236-3p/HOXB7 pathway. PMID: 30388035
    2. miR-196b-5p inhibition led to significantly increased colorectal cancer cell migration/invasion and metastases formation in mice, whereas ectopic overexpression showed the opposite phenotype. Molecular profiling and target confirmation identified an interaction between miR-196b-5p and HOXB7 and GALNT5, which in turn regulated colorectal cancer cell migration PMID: 28533224
    3. The expression of HOXB7 was upregulated in osteosarcoma tissues and cells compared with paired adjacent nontumor bone tissues and osteoblastic cells using reverse transcriptionquantitative polymer chain reaction and western blotting. HOXB7 knockdown dramatically suppressed cell viability, proliferation, migration and epithelialmesenchymal transition. PMID: 28677742
    4. downregulation of HOXB7 inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in osteosarcoma cells. PMID: 27983923
    5. HOXB7 promotes HCC cell proliferation, migration, and invasion through the bFGF-induced MAPK/ERK pathway activation. It might be a novel prognostic factor in HCC and a promising therapeutic target for tumor metastasis and recurrence. PMID: 28454092
    6. Overexpression of HOXB7 was significantly correlated with poor prognosis of HCC. HOXB7 up-regulated c-Myc and Slug expression via the AKT pathway to promote the acquisition of stem-like properties and facilitate epithelial-mesenchymal transition of hepatoma cells, accelerating the malignant progression of HCC. PMID: 28646927
    7. MiR-376c-3p suppresses the fission, proliferation, migration and invasion and induces cell apoptosis of oral squamous cancer cells via targeting HOXB7. PMID: 28482289
    8. our results showed that increased expression of HOXB7 might play an important role in promoting GC proliferation, migration and invasion by inducing both AKT and MAPK pathways, thus resulting in progression of, and poor prognosis in GC patients. PMID: 27901487
    9. the overexpression of HOXB7 in HSC-4 and KB/VCR cells reduces the sensitivity of the cells to chemo-radiotherapy-induced apoptosis and promotes oral cancer cell migration and invasion via upregulation of TGFbeta2. PMID: 27834359
    10. These findings suggest that hoxb7 and hoxb9 proteins might play a role in salivary gland tumourigenesis, but in contrast to the reported for other human cancers, they were not significant prognostic determinants in the sample studied. PMID: 26991799
    11. These results suggested that HOXB7 stimulates ERK1/2 phosphorylation and provided evidence that HOXB7, besides its role in transcriptional regulation, also promotes cell motility and invasiveness. PMID: 28912272
    12. The study suggests that HOXB7 has an oncogenic role in gastric cancer, which might be related to the modulation of Akt/PTEN activity to induce cell migration/invasion and anti-apoptotic effects. PMID: 26968988
    13. Suggest that simultaneous targeting of key regulatory miRNA miR-222 and HOXB7 may be a useful strategy for prevention of colorectal cancer metastasis. PMID: 27855613
    14. HOXB7 expression was significantly associated with larger tumor size and higher rate of biliary invasion in hepatocellular carcinoma. PMID: 27272787
    15. HOXB7 is generally overexpressed in gastric cancer, is associated with patient clinical characteristics, and specifically promotes gastric cancer cell malignant biological properties PMID: 26307396
    16. MiR-337 targets HOXB7 and effects significant suppression of pancreatic ductal adenocarcinoma (PDAC) cell proliferation and invasion. PMID: 25183455
    17. Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 and Cdx2 in colon cancer cells. PMID: 26902420
    18. HOXB7 protein expression level is downregulated following siRNA transfection and downregulation of HOXB7 gene expression effectively inhibits MCF-7 cell proliferation. PMID: 26135503
    19. Myelomeningocele is significantly associated with HOXB7 hypomethylation. PMID: 25565354
    20. HOXB7 Is an ERalpha Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance PMID: 26180042
    21. HOXB7 could promote cancer cell proliferation and might be an independent prognostic factor for patients with esophageal squamous cell carcinoma. PMID: 26076456
    22. Study reports >1,500 chromatin binding sites in the genome of a breast cancer cell line overexpressing HOXB7 and identifies some potential direct targets that are located nearby. PMID: 26014856
    23. Results demonstrate HOXB7 as a master factor driving progenitors behavior lifetime, providing a better understanding of bone senescence and leading to an optimization of MSC performance. PMID: 25428821
    24. HoxB7 is associated with tumor metastasis in patients with lung adenocarcinoma and HoxB7 may be implicated in promoting the development of lung adenocarcinoma through activation of the TGF-beta/SMAD3 signaling. PMID: 26403398
    25. our results suggest that HOXB7 promotes tumor progression in a cell-autonomous and non-cell-autonomous manner through activation of the TGFbeta signaling pathway. PMID: 25542862
    26. Results suggest that p53-regulated TUG1 is a growth regulator, which acts in part through control of HOXB7 in non-small cell lung cancer. PMID: 24853421
    27. HOXB7 was over-expressed and miR-337 was minimally expressed in pancreatic ductal adenocarcinoma PMID: 24641834
    28. HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis. PMID: 24088503
    29. HOXB7 promotes LAC progression by enhancing proliferation and metastasis. PMID: 22911672
    30. MicroRNA-196b regulates the HOXB7-VEGF axis in cervical cancer. PMID: 23861821
    31. findings suggest the disruption of the HOXB7/PBX2 complexes, miR-221&222 inhibition or even better their combination, as innovative therapeutic approaches PMID: 23400877
    32. HOXB7 is frequently overexpressed in pancreatic adenocarcinoma, specifically promotes invasive phenotype, and is associated with lymph node metastasis and worse survival outcome. PMID: 22914903
    33. Measuring IGF2BP3, HOXB7 and NEK2 mRNA levels by RT-PCR in addition to cytology has the potential to improve detection of malignant biliary disorders from brush cytology specimens. PMID: 22879911
    34. a novel mechanism whereby polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7 PMID: 22844406
    35. the absence of HoxB7 leads to inefficient viral progeny production, as HAdV5 gene expression is highly regulated by HoxB7-mediated activation of various adenoviral promoters. PMID: 22553335
    36. The current study demonstrates that the expression of HOXB7 is an independent prognostic marker for oral squamous cell carcinoma. PMID: 22239410
    37. Up-regulation of EGFR occurs through direct binding of HOXB7 to the EGFR promoter, enhancing transcriptional activity. PMID: 21690342
    38. Data indicate that HOXB7 and related HOX genes are upregulated in plasma cells of specific subsets of multiple myeloma patients lacking major immunoglobulin heavy chain locus translocations, irrespective of hyperdiploidy or other cytogenetic lesions. PMID: 21953534
    39. Here, we showed that PI3K/AKT and MAPK pathways were activated because p-ERK, p-AKT and p-GSK3-beta were upregulated by HOXB7. PMID: 21474578
    40. confirmed that HOXB7 overexpression by multiple myeloma (MM) cells stimulated tumor growth, increased MM-associated angiogenesis and the expression of pro-angiogenic genes by microarray analysis PMID: 21183939
    41. Strongly reduced expression of the microRNA miR-196a in melanoma cells compared to healthy melanocytes leads to enhanced HOX-B7 mRNA and protein levels, which subsequently raise Ets-1 activity by inducing basic fibroblast growth factor (bFGF). PMID: 20480203
    42. Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients PMID: 19878270
    43. HOXB7 may contribute to oral carcinogenesis by increasing tumor cell proliferation PMID: 19956843
    44. Identification of transcription factors that regulate HOXB7 expression. PMID: 12697323
    45. HOXB7 is expressed from primordial and early primary stage follicles through to germinal vesicle (GV) oocytes. PMID: 16597639
    46. Homeobox B7 (HoxB7) mRNA is overexpressed in biliary cancer cell lines and possibly involved in the pathogenesis of bile duct cancer. PMID: 16673309
    47. HOXB7 promotes tumor invasion through activation of Ras/Rho pathway by up-regulating bFGF. HOXB7 overexpression causes epithelial-mesenchymal transition in epithelial cells, accompanied by aggressive properties of tumorigenicity, migration, & invasion. PMID: 17018609
    48. thalidomide inhibits the RA-induced HOXB7 expression in glioblastoma cells PMID: 17514648

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5118

    OMIM: 142962

    KEGG: hsa:3217

    STRING: 9606.ENSP00000239165

    UniGene: Hs.436181