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  4. Recombinant Human Homeobox protein Hox-B13 (HOXB13)

Recombinant Human Homeobox protein Hox-B13 (HOXB13)

  • 货号：
    CSB-YP842162HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP842162HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP842162HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP842162HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP842162HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXB13
  • Uniprot No.：
  • 别名：
    Homeo box B13; Homeobox B13; Homeobox protein Hox B13; Homeobox protein Hox-B13; Homeobox protein HoxB13; HOX B13; HOXB 13; HOXB13; HXB13_HUMAN; PSGD; PSGD protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-284
  • 氨基酸序列
    MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
  • 基因功能参考文献：
    1. These results indicate that risk alleles of HOXB13 and common variant SNPs are important components of inherited prostate cancer risk in the Norwegian population, although these factors appear to contribute little to the malignancy's aggressiveness. PMID: 29181843
    2. Data show that homeo box B13 protein (HOXB13) single nucleotide polymorphisms (SNPs) missense mutations resulted in changed protein stability. PMID: 28272408
    3. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
    4. These results identify HoxB13 as a pivotal upstream regulator of AR-V7-driven transcriptomes that are often cell context-dependent in CRPC, suggesting that HoxB13 may serve as a therapeutic target for AR-V7-driven prostate tumors. PMID: 29844167
    5. This study evaluated the linkage evidence that identified recurrent mutation in HOXB13 as a risk factor for prostatic neoplasms. PMID: 28790484
    6. this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in laryngeal squamous cell carcinoma (LSCC). Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients. PMID: 28808656
    7. none of the recurrent HOXB13 mutations that were identified in the Dutch population were associated with breast cancer risk, although it may be worthwhile to evaluate p.R217C in a larger study or a population with a higher allele frequency. PMID: 27424772
    8. our results indicated that the G84E mutation in HOXB13 gene might increase susceptibility to prostate cancer PMID: 27626483
    9. HOXB13 mutation is associated with prostate tumors. PMID: 28186998
    10. CCAT1 regulates HOXB13 as a molecular decoy for miR-7, a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration in esophageal squamous cell carcinoma PMID: 27956498
    11. This study presents in silico prediction approaches of the deleterious ns single nucleotide polymorphisms (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer. PMID: 28072499
    12. This is the first study to investigate the HOXB13 G84E mutation in Danish men. The mutation was detected in 0.49% of controls and in 2.51% of cases, and was associated with 5.12-fold increased relative risk of being diagnosed with prostate cancer. In our RP cohort, HOXB13 mutation carriers were more likely to develop aggressive prostate cancer. PMID: 26779768
    13. HOXB13 is a useful marker for prostate origin when doubt exists regarding the site of the primary of a metastatic lesion PMID: 26931741
    14. Tumor-associated macrophage-secreted CXCL8 downregulated the ERalpha expression of endometrial cancer cells via HOXB13, which may be associated with cancer invasion, metastasis and poor prognosis. PMID: 27018308
    15. Study provides insights suggesting that HOXB13 plays an important role in prostate tumorigenesis and malignant progression via the regulation of both p21 and JNK signaling. PMID: 26781690
    16. The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio PMID: 26728744
    17. Studies indicate that the germline homeo box B13 protein (HOXB13) p.Gly84Glu mutation is significantly increased the risk of cancers. PMID: 26517352
    18. review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer PMID: 26709644
    19. Recent studies have shown that HOXB13 is a strong candidate for familial Prostate cancer gene. PMID: 26841725
    20. The strongest predictors are the BRCA2 mutations, and the highly penetrant G84E mutation in HOXB13 PMID: 26638190
    21. We showed for the first time that HOXB13 is a sensitive and specific marker for detection of prostatic origin in distant metastases. PMID: 26590121
    22. The associations between HOXB13 and prostate, leukemia, and bladder suggest that this gene is important in carcinogenesis. PMID: 26108461
    23. Hoxb-13 overexpression is correlated with tumor angiogenesis, aberrant expression of EMT-associated markers and aggressive clinicopathological characteristics in pancreatic carcinoma. PMID: 26261579
    24. The prevalence of somatic HOXB13 mutations in prostate cancer. PMID: 26176944
    25. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
    26. our study highlights HOXB13 as strong and independent prognostic marker in prostate cancer PMID: 25825985
    27. Data show that transcription factor FOXA1 and homeodomain protein HOXB13 colocalize with androgen receptor (AR) at tumor-specific AR binding sites. PMID: 26457646
    28. HOXB13 G84E germline mutation is associated with prostate cancer risk. PMID: 25595936
    29. Increased expression of HOXB13 protein is associated with HPV infection and cervical cancer progression. PMID: 25743797
    30. P63 and HOXB13 is helpful in resolving the diagnosis. PMID: 26200506
    31. We then show the value of this approach by using the imputed data to investigate the impact of the HOXB13 G84E mutation on age-specific prostate cancer risk and on risk of fourteen other cancers in the cohort PMID: 25629170
    32. our results suggest that increased HOXB13 expression is associated with tumor angiogenesis and progression in hepatocellular carcinoma PMID: 25031711
    33. High HOXB13 expression is associated with breast cancer. PMID: 23497539
    34. The results suggest that the HOXB13-mediated promotion of tumor cell invasion is accomplished mainly through the downregulation of PDEF expression. PMID: 24898171
    35. While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk PMID: 24310616
    36. identified common variants partially correlated with coding variant in the HOXB13 gene (G84E, rs138213197), which has been identified recently as a moderate penetrance prostate cancer susceptibility allele PMID: 24550738
    37. HOXB13 promotes PCa invasion and metastasis by decreasing intracellular zinc levels, thus stimulating NF-kappaB signals, and acts as a modulator of intracellular zinc levels that promotes the malignant characteristics of PCa PMID: 24096478
    38. HOXB13 contributes to G1/S and G2/M checkpoint controls in the prostate. PMID: 24325868
    39. It might enhance cell injury caused by oxidative stress. PMID: 24213000
    40. No HOXB13 mutation is associated with Ashkenazi Jewish men with prostate cancer. PMID: 23475555
    41. HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer PMID: 22841674
    42. findings suggest that novel molecular pathways may drive prostate cancer in HOXB13 G84E carriers PMID: 24722062
    43. carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele. PMID: 24148311
    44. Our findings provide further evidences that the rare mutation in HOXB13 contributes to both hereditary and sporadic PCa risk. PMID: 24026887
    45. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. PMID: 24390282
    46. Letter/Meta-analysis: HOXB13 germline mutations in European men with prostate neoplasms. PMID: 23518396
    47. This report is the first to suggest a risk of colorectal cancer associated with mutations in the HOXB13 gene PMID: 23541221
    48. Our results demonstrate that HOXB13 expression identifies prostatic origin of a carcinoma PMID: 24146108
    49. High HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression. PMID: 23832664
    50. HOXB13 mutation is associated with prostate cancer. PMID: 23396964

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  • 相关疾病：
    Prostate cancer (PC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5112

    OMIM: 176807

    KEGG: hsa:10481

    STRING: 9606.ENSP00000290295

    UniGene: Hs.66731