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  4. Recombinant Human Homeobox protein Hox-A10 (HOXA10)

Recombinant Human Homeobox protein Hox-A10 (HOXA10)

  • 货号：
    CSB-YP010648HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010648HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010648HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010648HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010648HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA10
  • Uniprot No.：
  • 别名：
    Centaurin alpha 1 like ; Homeo box A10 ; Homeobox A10; Homeobox protein 1H ; Homeobox protein Hox A10; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; Homeobox protein Hox-A10; Homeobox protein HOXA10 ; HOX 1; HOX 1.8; HOX 1H; HOX A10; HOX1; HOX1.8; HOX1H ; HOXA 10; HOXA10; HOXA10 protein; HXA10_HUMAN; MGC12859; PL
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein of Isoform 2
  • 表达区域：
    1-94
  • 氨基酸序列
    MCQGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLT DRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
  • 基因功能参考文献：
    1. HOXA10 protein and mRNA were decreased in ovarian endometriomas compared with eutopic endometria of women with endometriosis and normal endometria. Moreover, HOXA10 was found to have a significant negative correlation with autophagy. PMID: 29658437
    2. Study addressed HOXA10-AS as a regulator of cell proliferation and apoptosis in glioma, and identified HOXA10 as a target of HOXA10-AS. Additionally, the oncogene HOXA10 had an important role in promoting the tumorigenesis of glioma. PMID: 30132568
    3. the present study demonstrated that miR135a serves as a tumor suppressor in AML by targeting HOXA10, and miR135a may be a promising prognostic biomarker for AML patients. PMID: 29845297
    4. Significant HOXA10 overexpression in CRC may be a potential biomarker indicating poor prognosis and 5-FU resistance PMID: 29870276
    5. Results show that the inhibition of HOXA10 in DAOY cell line led to increased in vitro cell migration while in vitro cell proliferation or in vivo tumorigenic potential were unaffected. This suggests that HOXA10 plays a role in migration events. PMID: 29039487
    6. We conclude that the expression patterns of HoxA10, HoxA11, and HoxA13 and their actions in regulating CAP genes in the uterus create regionalized myometrium phenotypes in women that may be important to control regionalized myometrium contractility for maintaining pregnancy. PMID: 28372536
    7. These results suggest that downregulation of HOXA10 in the decidual cells promotes the expression of a cascade in the trophoblast cells, leading to an increase in matrix metalloproteinases to facilitate invasion. PMID: 28520923
    8. Endometrial expression of HOXA10 and E-cadherin are reduced in women with recurrent implantation failure and recurrent miscarriage. PMID: 27793380
    9. Reduced expression of HOXA10 is associated with Hydrosalpinx. PMID: 26840046
    10. To summarize, significant differential methylation of HOXA10 and COMT promoter regions was found between the ectopic and eutopic endometrial tissues. This is the first study investigating the methylation of HOXA10 and COMT genes and their linkage to endometriosis in Chinese patients. PMID: 28074437
    11. using both knockdown and knockout approaches we show that Hottip expression is required for activation of the 5' Hoxa genes (Hoxa13 and Hoxa10/11) and for retaining Mll1 at the 5' end of Hoxa. Moreover, we demonstrate that artificially inducing Hottip expression is sufficient to activate the 5' Hoxa genes and that Hottip RNA binds to the 5' end of Hoxa PMID: 28384324
    12. HOXA10 is overexpressed in oral squamous cell carcinoma (OSCC) and its expression is functionally associated with several important biological processes related to oral tumorigenesis, such as proliferation, migration and invasion. PMID: 26097543
    13. The results demonstrated that mutation in HOXA10 gene contributes to the pathogenesis of cryptorchidism, but may not be a common cause. PMID: 27108669
    14. The HOXA10 gene in women with endometriosis was hypomethylated compared to controls. PMID: 26865543
    15. HOXA10 was expressed at a high level in the K562/ADM cells, and knockdown of HOXA10 enhances the sensitivity of the K562/ADM cells to cytotoxic killing by the therapeutic drug, ADR, as a result of the increased intracellular accumulation of ADR. PMID: 27035504
    16. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx. PMID: 26552702
    17. The combinatory expression of HOXA10 and CD44 was correlated with poor gastric cancer prognosis. PMID: 26552644
    18. confirmed that HOXA10 promoted epithelialmesenchymal transition in ovarian cancer cells PMID: 26151663
    19. Promoter activity of HOXA10 lies in 5.3-6.1 kb upstream of protein coding region.CTCF negatively regulates HOXA10 expression in breast cancer cells.CTCF flanks important promoter element of HOXA10. PMID: 26478432
    20. The results showed overexpression of HOXA10 mRNA and protein in Ishikawa cell. PMID: 25757424
    21. HOXA10 is expressed in rectosigmoid endometriosis, where it likely imparts the de novo identity of endometriotic lesions. PMID: 25217304
    22. miR-494 repressed the expression of HOXA10 and also reduced the proliferation of oral cancer cells. These data give more evidence of the role of miR-494 as a tumor suppressor miRNA in oral cancer. PMID: 25500095
    23. Peri-implantation HOXA-10 mRNA expression is increased following laparoscopic endometrioma resection. PMID: 26056923
    24. the CpG island of the HOXA10 alternative promoter appears to escape hypermethylation in the HOX-high glioblastoma. PMID: 25622821
    25. Data show that recruitment of MLL1 (mixed lineage leukaemia histone methylase 1) to the homeobox-containing gene HOXA10 EREs (estrogen response elements) is mediated via ERalpha (estrogen receptor alpha). PMID: 25307539
    26. Expression of HOXA10 and p21 gene decreased in endometrial cancer, and the expression level of HOXA10 was correlated with cancer grade. PMID: 24943991
    27. regulatory mechanism of HoxA10 in prostate cancer PMID: 24951955
    28. The regulatory mechanism of miR-218 in human hepatocellular carcinoma cells was acting through PTEN/AKT/PI3K pathway and possibly associated with HoxA10. PMID: 25120782
    29. The HOXA10 gene is more methylated in the eutopic endometrium of patients with endometriosis. PMID: 24963168
    30. Inhibition of HOXA10 expression with miR-135a mimics and HOXA10 siRNA resulted in cell apoptosis with concomitant enhancement of caspase-3, increase of p53 expression and reduction of Bcl-2 expression, and also suppressed cell growth and adhesion. PMID: 24607788
    31. this study demonstrated that an increased HOXA10 expression in human ovarian cancer is a result of the co-activation of HOXA10 gene promoter's hypomethylation and the binding of transcription factor WT1. PMID: 23888944
    32. these results suggested that the miR-135a-VLDLR-p38 axis may contribute to gallbladder cancer cell proliferation PMID: 24903309
    33. HOXA10 promotes cell invasion and MMP-3 expression of pancreatic cancer cells via TGFbeta2-p38 MAPK pathway. PMID: 24464212
    34. Lower expression of HOXA10 is associated with endometriosis-associated infertility. PMID: 23979130
    35. Endometrial cancer tissue displays significantly higher methylation status in HOXA10 gene promoter than normal tissue. PMID: 23815210
    36. The level of HOXA10 decreases in the eutopic endometrium of patients with endometriosis. PMID: 22915150
    37. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation. PMID: 24565841
    38. Co-activation of miR-196b and HOXA10 characterized a poor-prognosis subgroup of patients with gastric cancer. PMID: 24222951
    39. HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells. PMID: 24037888
    40. This study documented significantly higher HOXA10 promoter methylation levels in women with ovarian endometriomas than in healthy controls during the mid-luteal phase. PMID: 24032603
    41. HOXA10 has been found to be methylated in all hereditary breast cancer patients analyzed but never in healthy subjects. PMID: 23051705
    42. There are complex etiopathogenic mechanisms for endometriosis between INFG and HOXA10. PMID: 23412855
    43. Rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia. PMID: 23376215
    44. Compared with the negative control and untreated groups, mRNA level of HOXA10 decreased by (92.3+/-1.3)%, protein levels decreased by 91.1%, and the inhibition rate of U937 cells [(43.9+/-0.7)%] increased in the interference group PMID: 23092574
    45. We found that MLL directly activates the Homeobox gene HOXA10 in human glioblastoma PMID: 23108137
    46. a molecular mechanisms through which increased expression of HoxA10 increases Cdx4 expression by direct CDX4 activation and by Fgf2-induced beta-catenin activity. This results in Cdx4-induced HoxA10-expression, creating a positive feedback mechanism PMID: 23038246
    47. found that increased Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin protein PMID: 22493287
    48. HOXA10 expression was associated with GC with the intestinal mucin phenotype. PMID: 22411957
    49. regulates FKBP4 during decidualization PMID: 22279148
    50. mutation of HOXA10 gene may contribute to the development of Mullerian duct anomalies; it is an important transcription factor in reproductive tract development PMID: 21900391

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5100

    OMIM: 142957

    KEGG: hsa:3206

    STRING: 9606.ENSP00000283921

    UniGene: Hs.110637